New hope for brain cancer? experimental drug combo tested in early trial

NCT ID NCT05635734

First seen Feb 05, 2026 · Last updated Apr 28, 2026 · Updated 12 times

Summary

This early-phase study tests whether adding the experimental drug azeliragon to standard radiation and chemotherapy (temozolomide) is safe for people with newly diagnosed glioblastoma, an aggressive brain cancer. About 18 participants will receive the combination to find the best dose and look for early signs that the tumor shrinks or stops growing. The goal is to control the disease, not cure it, as ongoing treatment is needed.

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Contacts and locations

Locations

  • Hospital Clínic de Barcelona

    Barcelona, Barcelona, 08036, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, Madrid, 28041, Spain

  • Hospital Universitario Ramon y Cajal

    Madrid, Madrid, 28034, Spain

  • Hospital del Mar

    Barcelona, Barcelona, 08003, Spain

Conditions

Explore the condition pages connected to this study.