GLIOBLASTOMA

This study tests a new approach for people with a newly diagnosed aggressive brain cancer called glioblastoma. The treatment delivers a drug called cetuximab directly to the brain tumor through a thin tube in an artery, after temporarily opening the blood-brain barrier. The goal …

This early-phase study tests a new two-drug combination for adults whose high-grade glioma (a fast-growing brain tumor) has returned after standard treatment. The drugs are temozolomide (a chemotherapy pill given daily at low doses) and abexinostat (an experimental drug that may …

This study tests a new treatment for glioblastoma, a fast-growing brain cancer. It combines a drug (5-ALA) with a special ultrasound device that aims to target tumor cells without surgery. About 100 people who have already had standard treatments will be randomly assigned to get …

This study tests methimazole, a drug normally used for thyroid problems, in people with progressive glioblastoma (a fast-growing brain tumor). Researchers want to see if it can help control the disease and how safe it is. About 19 adults will receive different doses to find the b…

This early-phase study tests an experimental oral drug called GLIX1 in 30 adults whose high-grade glioma (a fast-growing brain tumor) has come back or worsened after standard treatments. The main goals are to find a safe dose and check for side effects. Researchers will also watc…

This study tests a new treatment called EBNK-001, made from donor immune cells (natural killer cells), in people with advanced solid tumors that have not responded to standard therapies. Participants receive the cells after chemotherapy to prepare the body, along with low-dose in…

This early-phase study tests a new drug called FT536 for adults with a severe, recurring brain cancer (Grade 4 astrocytoma). About 9 people whose tumor can be surgically removed will receive a single injection of FT536 directly into the tumor during surgery. The main goal is to c…

This study tests a new surgical technique for people with a fast-growing brain cancer called glioblastoma. During surgery to remove the tumor, doctors place a piece of the patient's own tissue (from the scalp or skull lining) into the empty space. This flap may help bypass the bl…

This early-stage study tests whether a new treatment using a patient's own immune cells, engineered to attack two specific targets on glioblastoma cells, is safe. It involves 9 adults with a newly diagnosed, aggressive form of glioblastoma who have completed radiation but show no…

This early-phase trial tests whether two existing drugs—senicapoc and perampanel—can safely block electrical signals that help glioblastoma brain tumors grow. About 36 adults with newly diagnosed glioblastoma will receive these drugs alongside standard treatment (surgery, radiati…

This early-phase trial tests a new treatment for adults with glioblastoma or other high-grade gliomas that have come back after standard therapy. The treatment uses specially designed immune cells (CAR-NK cells) that are given directly into the brain to target two tumor markers a…

This early-stage trial tests a new treatment for children and young adults up to age 21 with certain brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a pro…

This early-phase study is testing whether giving the immunotherapy drug ipilimumab before standard surgery and chemoradiation is safe and can help control glioblastoma, a fast-growing brain cancer. About 16 adults with newly diagnosed glioblastoma will receive up to two doses of …

This study tests whether adding the immunotherapy drug pembrolizumab to standard treatment (Optune therapy and chemotherapy) can help people with newly diagnosed glioblastoma live longer. About 741 adults who have had surgery for glioblastoma will be randomly assigned to receive …

This early-stage trial tests a new treatment called E-SYNC CAR T cells for people with a specific type of glioblastoma brain cancer. The therapy uses a patient's own immune cells, modified in a lab to better recognize and attack the tumor. About 20 adults will receive the cells a…

This phase 3 trial tests whether an ultrasound device called SonoCloud-9 can temporarily open the blood-brain barrier, allowing more carboplatin chemotherapy to reach glioblastoma tumors that have returned. About 560 participants will be randomly assigned to receive either the So…

This phase 3 trial tests whether delivering the drug Avastin directly into the brain's arteries (called SIACI) alongside standard chemotherapy and radiation can help people with newly diagnosed glioblastoma live longer. About 432 adults with this aggressive brain cancer will be r…

This early-phase study tests an experimental drug called RSC-1255, given alone or with hydroxychloroquine, in people with advanced solid tumors (like lung, colon, pancreatic, or brain cancer) that have stopped responding to standard treatments. The main goals are to find a safe d…

This study tests an experimental drug called BDTX-1535 in people with aggressive brain tumors (high-grade glioma or glioblastoma) that have certain changes in the EGFR gene. The drug aims to block a growth signal that these tumors rely on. The trial first measures how much drug r…

This early-phase study tests a new treatment for adults with glioblastoma or other high-grade brain tumors that have come back. The treatment uses the patient's own immune cells, modified to target two specific markers on the tumor cells, and is delivered directly to the brain. T…

This early study tests whether adding the drug azeliragon to standard chemoradiotherapy can help the immune system fight glioblastoma, an aggressive brain cancer. About 12 adults with newly diagnosed glioblastoma will receive either standard treatment or standard treatment plus a…

This early-stage study tests an oral drug called ONC206 in adults with brain tumors that have come back. The main goal is to find the safest dose and check for side effects. About 102 participants will take the drug once or several times a week.

This study tests a combination of drugs (nogapendekin alfa inbakicept, bevacizumab, and immune cells) with or without tumor treatment fields in people whose glioblastoma has returned or worsened. The goal is to see if these treatments can safely control the cancer and improve sur…

This study tests whether using a patient's own tumor cells to find the best drugs can improve survival in people with a newly diagnosed, aggressive brain cancer called glioblastoma. About 240 adults will either receive standard treatment or have their tumor cells tested in a lab …

This study tests a new way to treat glioblastoma, a fast-growing brain tumor. Right after removing the tumor, doctors give a single dose of targeted radiation inside the cavity using a special balloon device. Then patients receive standard chemotherapy and radiation. The goal is …

This early-phase study tests whether using Tumor Treating Fields (TTFields) before surgery and radiation is safe for people newly diagnosed with glioblastoma, an aggressive brain cancer. About 42 participants will receive TTFields before their standard treatment and provide extra…

This early-phase trial is testing whether a special egg yolk powder called Salovum can reduce pressure and inflammation inside glioblastoma brain tumors. Ten adults with suspected glioblastoma will have probes placed during a biopsy to measure tumor pressure and fluid before and …

This study tests whether adding a focused ultrasound device (NaviFUS) to the standard drug Avastin helps people with recurrent glioblastoma (a type of aggressive brain cancer) live longer without their cancer growing. About 32 adults whose cancer returned after standard treatment…

This study tests whether sitagliptin, a diabetes drug, can help the immune system fight glioblastoma, an aggressive brain cancer. About 48 adults with progressive grade 4 gliomas will receive sitagliptin before surgery to see if it increases cancer-fighting immune cells in the tu…

This early-stage trial tests a new treatment using donor immune cells (CAR-NK cells) that are specially designed to attack cancer. Up to 85 adults with advanced solid tumors that have not responded to standard therapy will receive cells targeting one or two specific markers found…

This program provides early access to an experimental drug called AVM0703 for people with various solid tumors and blood cancers, including hard-to-treat types like glioblastoma and metastatic breast cancer. It is available to patients in the US whose doctor requests it. So far, …

This study tests whether a daily egg powder enriched with a natural protein called antisecretory factor can help people with newly diagnosed glioblastoma live longer. About 300 participants will receive either the active egg powder or a placebo alongside standard chemotherapy and…

This study tests several new drugs, alone or with standard chemotherapy, for people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 460 participants will receive one of the experimental treatments to see if they live longer compared to standard therapy. The …

This early-phase trial tests whether adding ibrutinib to an existing immunotherapy and chemotherapy regimen can safely improve treatment for children and young adults (ages 6–25) with brain cancers like medulloblastoma or glioblastoma that have come back or not responded to stand…

This study tests a drug called PLX038 in adults with brain or spinal cord tumors, especially those with changes in the MYC or MYCN genes. About 146 people will receive the drug through an IV every 3 weeks for up to 7 months, along with a second drug to prevent infection. The goal…

This early-phase trial tests whether the drug troriluzole can affect brain activity and reduce harmful glutamate levels in people with recurrent glioblastoma, an aggressive brain cancer. About 27 adults whose tumor has returned after standard treatment will receive the drug befor…

This study tests a new approach for people with a returning, aggressive brain cancer called glioblastoma. Doctors take a piece of tissue from the patient's belly and place it into the brain during surgery to remove the tumor. The goal is to see if this is safe and might help deli…

This early-phase study tests a new drug called RZ-001 combined with valganciclovir in people with glioblastoma, an aggressive brain cancer. The goal is to find a safe dose and see if the treatment can shrink tumors or help people live longer. About 43 adults with a specific genet…

This early-phase study tests a new treatment for people with a recurring type of brain cancer called glioblastoma. The treatment uses specially designed immune cells (NK-92/5.28.z) that are injected directly into the brain to attack cancer cells. The main goals are to check safet…

This study tests whether adding a cannabis-based mouth spray (Nabiximols) to standard chemotherapy can help people with a returning glioblastoma brain tumor live longer. About 120 adults whose tumor has returned will be randomly assigned to get either the cannabis spray or a plac…

This study is for people with glioblastoma, an aggressive brain cancer. The standard treatment includes radiation to the tumor plus a safety margin, which can damage healthy brain tissue and cause side effects. The BELGICA trial tests whether using a smaller radiation area can re…

This early-phase study tests a new approach for people with recurrent high-grade astrocytomas, a type of aggressive brain cancer. Participants will receive a special virus injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the …

This study tests a new treatment called TLX101-Tx, which delivers radiation directly to glioblastoma cells, combined with standard chemotherapy (lomustine) in adults whose brain cancer has returned after initial treatment. The goal is to see if the combination works better than c…

This early-phase study tests a new treatment called CARv3-TEAM-E T cells for people with glioblastoma, a fast-growing brain cancer. The treatment uses the patient's own immune cells, modified to attack cancer cells. The main goal is to find the safest dose and monitor side effect…

This early-phase study tests a drug called WSD0628 combined with radiation therapy for people whose high-grade glioma (a type of brain tumor) has come back after prior treatment. The main goal is to find the safest dose and check for side effects. About 94 adults with specific br…

This study tests several treatments at once for people with glioblastoma, an aggressive brain cancer. It includes both newly diagnosed and recurrent cases, with up to 2,250 participants worldwide. The goal is to see which treatments improve survival and control the disease better…

This study tests the drug lorlatinib in children (ages 1-21) with newly diagnosed high-grade glioma that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor and to check its safety when given alone or with chemotherap…

This study tests a new drug called ONC206 in children and young adults with a rare, aggressive brain tumor called diffuse midline glioma (DMG) or other returning brain cancers. The goal is to find the best dose that is safe and can shrink tumors. ONC206 works by triggering a stre…

This early-phase study tests an experimental drug called CUE-102 in 18 adults whose glioblastoma (a type of brain cancer) has come back after initial treatment. The main goal is to find the safest dose and check for side effects. Participants must have a specific genetic marker (…

This program provides the experimental drug ulixertinib to people with advanced solid tumors that have certain gene mutations (MAPK pathway). It is for patients who have not responded well to or have run out of standard treatments. The goal is to control the disease and possibly …

This study tests a new drug, VRT106, in 42 adults whose glioblastoma brain cancer has returned or worsened. The main goals are to check if the drug is safe and to find the best dose. Researchers will also look at whether it helps shrink tumors or extend survival.

This study tests a new drug that delivers radiation directly to cancer cells with a specific marker (GRPR). It is for adults with advanced cancers of the prostate, breast, lung, colon, cervix, or brain that have come back or spread. The main goal is to find a safe dose and see if…

This study tests whether adding the drug ruxolitinib to standard treatment (radiation and temozolomide) helps people with newly diagnosed glioblastoma live longer. About 190 adults will be randomly assigned to receive either the standard treatment alone or standard treatment plus…

This study is for people aged 65 and older with a type of brain cancer called glioblastoma that has a specific marker (unmethylated MGMT) making standard treatment less effective. Researchers are testing a different way of giving the chemotherapy drug temozolomide—daily instead o…

This early-phase study tests a new treatment for aggressive brain tumors (glioblastoma and pediatric high-grade gliomas). The therapy uses a patient's own immune cells, modified to target a protein called CD70 on tumor cells and to better reach the brain. The main goals are to ch…

This study tests whether adding a special radiation tile (GammaTile) during brain tumor surgery can help people with newly diagnosed glioblastoma live longer. About 766 adults will be randomly assigned to get either standard treatment or standard treatment plus the tile. The goal…

This study tests a two-step treatment for people newly diagnosed with high-grade gliomas, a fast-growing type of brain tumor. First, a laser is used to heat and destroy tumor tissue. Then, a short course of radiation is given to kill remaining cancer cells. The goal is to safely …

This study tests whether adding two different drug combinations after radiation can help children and young adults (up to age 21) with high-grade gliomas, including DIPG, live longer. One group receives ribociclib plus everolimus; another gets ribociclib plus temozolomide. The go…

This study tests a treatment plan for people whose brain tumors (gliomas) have come back after standard care. The approach uses laser heat to destroy tumor tissue, followed by a short course of focused radiation. The goal is to see if this combination is safe and can help control…

This study tests a combination of three drugs (trimipramine, atezolizumab, and bevacizumab) in people whose glioblastoma brain tumor has come back after standard treatment. About 59 participants will receive the treatment for up to 2 years. The goal is to see if the combo can slo…

This early-stage study tests whether combining laser heat therapy (LITT) with the chemotherapy drug lomustine is safe and feasible for adults whose glioblastoma has returned. About 20 participants will receive the laser treatment followed by lomustine within a week. Researchers w…

This study tests whether adding the chemotherapy drug capecitabine to the standard treatment temozolomide helps people with newly diagnosed glioblastoma live longer without their cancer growing. About 67 adults aged 18 to 74 who have completed initial radiation and chemo will tak…

This study tests a combination of three drugs (pembrolizumab, olaparib, and temozolomide) in people whose glioblastoma brain tumor has come back after prior treatment. The goal is to see if the drugs can boost the immune system's attack on the tumor and slow or stop its growth. A…

This study tests a new treatment for aggressive brain tumors (glioblastoma) that uses a radioactive substance attached to a targeting molecule. The therapy is given directly into the tumor area after standard treatments like surgery and chemotherapy. The goal is to see if it can …

This early-stage trial tests a new drug called Peposertib combined with radiation and chemotherapy for people with a fast-growing brain cancer (glioblastoma). The goal is to find the best dose and see if the drug can reach the brain to help kill tumor cells. About 29 adults with …

This study tests whether giving a higher dose of radiation along with a drug called bevacizumab can help people with a fast-growing brain tumor (glioblastoma) live longer. About 146 adults aged 18 to 70 with a specific type of glioblastoma will receive the treatment. The goal is …

This early-stage study tests whether combining a standard brain cancer drug (bevacizumab) with focused ultrasound can safely treat recurrent glioblastoma, an aggressive brain tumor. About 10 adults whose cancer has returned after standard therapy will receive the combination. The…

This study tests a drug called ivonescimab in 45 adults whose glioblastoma brain tumor has come back after standard treatment. Phase 1 finds the best dose with fewest side effects; Phase 2 checks if that dose can control the cancer. The goal is to manage the disease, not cure it.

This study tests a new approach for people newly diagnosed with aggressive brain cancers (glioblastoma or anaplastic astrocytoma). It combines a gene therapy (HSV-tk) with an antiviral drug, radiation, and chemotherapy. The goal is to see if this combination can help people live …

This early-stage study tests a new radioactive drug (131I-TLX101) given alongside standard treatment for people with newly diagnosed glioblastoma, an aggressive brain cancer. The main goal is to find the safest dose and check for side effects. About 12 adults who have had surgery…

This study tests a new way to treat aggressive brain cancers (like glioblastoma) that have come back after standard treatment. The drug cetuximab, which targets a protein common on these cancer cells, is infused directly into the brain artery along with a second round of radiatio…

This study tests whether adding silibinin (a milk thistle extract) to standard chemoradiation and maintenance chemotherapy can delay tumor growth in people with a specific type of newly diagnosed glioblastoma. About 110 adults whose tumors have a certain protein marker (STAT3-pos…

This study is for children and teens aged 3 to 18 with solid tumors that have come back or not responded to standard treatment. It combines two drugs: Lutathera, which targets tumor cells with a special receptor, and olaparib, which may make the radiation from Lutathera more effe…

This study tests whether a drug called niraparib works better than the standard chemotherapy temozolomide for adults with a newly-diagnosed, aggressive type of brain cancer called glioblastoma that has a specific genetic marker (MGMT unmethylated). About 450 participants will be …

This study tests a more intense treatment for a fast-growing type of brain cancer called IDH wildtype glioma. It combines higher doses of radiation with the chemotherapy drug temozolomide to try to stop the tumor from growing longer. The trial will enroll 40 adults with this spec…

This study tests a new, noninvasive technique called sonobiopsy that uses ultrasound to release tumor DNA into the bloodstream, making it easier to detect and monitor glioblastoma. About 40 adults with suspected glioblastoma will receive sonobiopsy before standard surgery. The go…

This study tests a device called the CONVIVO system, which acts like a high-powered microscope during brain tumor surgery. It helps surgeons tell the difference between normal and abnormal tissue right away. About 30 adults with various brain tumors will take part. The goal is to…

This study is testing a new radioactive tracer that attaches to a protein called LRRC15, found on many cancer cells. Researchers will use PET scans to see if this tracer can better detect and stage cancers like pancreatic, breast, lung, and brain tumors. The study includes 26 hea…

This study tests the drug apixaban to prevent blood clots in people with newly diagnosed grade 4 brain tumors (glioblastoma or astrocytoma). About 40 participants will take apixaban while receiving standard radiation and chemotherapy. The goal is to see if the drug is safe and re…

This study tests a new program called EASE, which uses a simple writing exercise to help adults with advanced cancer manage their fear of the future and related trauma symptoms. The study will include 250 people with advanced solid tumors, glioblastoma, or certain ovarian or lung…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers. The goal is to see if home treatment is preferred and just as safe. Participants will receive their usual cancer drugs at home from a specialized team, and researchers will …

This study tests whether a custom-made video, showing symptoms and side effects based on each patient's own brain scan, can lower anxiety for people with brain tumors and their caregivers during radiation treatment. About 117 patients with newly diagnosed glioma and their caregiv…

This study tests whether proton beam radiation causes fewer side effects than standard photon radiation in people with glioblastoma, a serious brain cancer. About 326 adults who need radiation therapy will be randomly assigned to one of the two methods. The goal is to see if prot…

This early-phase study tests whether two experimental drugs, ABBV-637 and ABBV-155, are safe when given alone or with another drug called ERAS-801 for people whose glioblastoma has come back. About 60 adults with a specific genetic marker (EGFR amplification) will take part. The …

This study tests whether a 6-week occupational therapy group programme can improve quality of life and daily functioning in adults with primary brain tumours who are on active treatment. Participants are randomly assigned to either the group programme or usual care (written infor…

This study looks at MRI scans from 50 people with glioblastoma (a serious brain cancer) to see if certain imaging features can predict which patients will respond to a drug called bevacizumab. Researchers will analyze tumor tissue and blood samples to find links between MRI patte…

This study collects samples of glioblastoma (a type of brain tumor) and blood from 120 adults during standard surgery. Researchers will examine different parts of the same tumor to see how they differ at the genetic level. The goal is to learn more about how the tumor works, whic…

This pilot study will use two types of PET scans and a powerful 7 Tesla MRI to create detailed metabolic profiles of glioblastoma, an aggressive brain cancer. Researchers aim to understand how the tumor uses energy, both before treatment and if it comes back. The study involves 1…

This study looks at whether a blood test can predict blood clots in people with certain cancers (lung, pancreas, stomach, or brain). About 200 patients will be followed for 12 months after starting treatment. The goal is to see if changes in the test can warn of a clot before it …

This study collects blood and tumor samples from 80 people with newly diagnosed glioblastoma to find biological markers that predict how well the tumor responds to Tumor Treating Fields (TTFields). Participants receive standard treatment plus TTFields, and samples are taken befor…

This study checks if it is safe and possible to do a special brain scan (PET-MRI) within 48 hours after surgery for glioblastoma, a serious brain cancer. About 15 adults who just had their first surgery for suspected glioblastoma will get this scan to see if it can find leftover …

This study looks at how much of the drug T-DXd gets into brain tumors after being injected into the body. It includes 30 adults with brain cancer that has the HER2 protein. The goal is to measure drug levels in the tumor during surgery to see if it could be an effective treatment…

This study is testing whether a dye called 5-ALA, which makes brain tumor cells glow during surgery, can also help detect tumor signals in the blood and urine. Researchers will take samples from 30 adults with glioblastoma or other brain tumors before and after the dye is given. …

This study is testing a new approach to personalize treatment for people with a fast-growing brain tumor called glioblastoma. Researchers will use a lab test on tumor cells to see which drugs might work best for each patient. The goal is to find out if this method can help more p…

This study looks at whether having surgery to remove a returning glioblastoma brain tumor helps people live longer and feel better compared to not having surgery. About 120 adults whose brain cancer has come back after standard treatment will be randomly assigned to either surger…

This early-phase study is testing a new radioactive imaging agent in 32 adults with various solid tumors. The goal is to see how the agent spreads through the body and whether it can highlight tumors on PET/CT scans. Participants receive a single injection of the agent and underg…

This study aims to analyze the genetic makeup of brain tumors in 350 children, adolescents, and young adults newly diagnosed with high-grade glioma or diffuse intrinsic pontine glioma. By identifying specific genetic changes, researchers hope to match patients with targeted treat…

This study tracks 200 adults having brain tumor surgery to see how often cerebrospinal fluid leaks occur, what increases the risk, and how doctors manage them. The goal is to find ways to reduce leaks and help patients recover faster.

This study tests a new MRI technique that highlights acidic areas in the brain, which may contain hidden glioblastoma cells not seen on standard scans. About 18 adults with newly diagnosed or recurrent glioblastoma will have surgery using this method to see if it is safe and can …

This study looks at whether certain brain chemicals can predict survival in people with glioblastoma (a fast-growing brain cancer) that has returned after standard treatment. Researchers will measure these chemicals with special scans 7 and 28 days after starting the drug bevaciz…

This study is for adults whose glioblastoma (a type of brain cancer) has come back after initial treatment. Researchers want to see if using a special PET scan (FDOPA-PET) to guide a precise form of radiation therapy can delay the cancer's return. About 54 participants will be ra…

This study is testing whether an artificial intelligence (AI) tool can help match cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers to see if the AI improves trial enrollment rates and patient outcomes. The goal is to…

This study tests whether three advanced MRI techniques can non-invasively visualize the immune cells and proteins surrounding glioblastoma tumors. Researchers aim to understand why some brain tumors are harder to treat. About 15 adults with suspected glioblastoma will have these …

This study is testing a small device called a microdialysis catheter that is placed in the brain during surgery for tumors like glioma or glioblastoma. The catheter collects fluid samples to measure biomarkers—natural substances that can show how severe the disease is. The goal i…

This study tests if recording electrical activity in and around high-grade glioma tumors during surgery can help predict where the tumor will grow back. Ten adults with aggressive brain tumors will have a small biopsy taken from the recording sites. The goal is to understand how …

This study looks at what factors—like genetics, immune system, and medical history—affect survival and quality of life in adults with glioblastoma, a severe brain cancer. About 200 participants will fill out online surveys and may provide a blood sample at home. The goal is to le…

This study compares two common methods of closing the skin after brain tumor surgery: running stitches (absorbable) and individual stitches (non-absorbable). The goal is to see which method leads to better wound healing and fewer complications like infection or fluid leaks. About…