New drug hope for kids with rare brain tumors
NCT ID NCT06333899
First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 28 times
Summary
This study tests the drug lorlatinib in children (ages 1 to 21) with a newly diagnosed high-grade glioma that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor and to check its safety when given with or after other treatments. About 15 children will take part.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
NOT_YET_RECRUITINGChicago, Illinois, 60611, United States
Contact Email: •••••@•••••
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Children's Hospital Colorado
NOT_YET_RECRUITINGAurora, Colorado, 80045, United States
Contact Email: •••••@•••••
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Children's Hospital of Philadelphia
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Email: •••••@•••••
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Children's National Medical Center
NOT_YET_RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact Email: •••••@•••••
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
Contact Email: •••••@•••••
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Dana-Farber Cancer Institute
NOT_YET_RECRUITINGBoston, Massachusetts, 02215, United States
Contact Email: •••••@•••••
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Duke University Health System
NOT_YET_RECRUITINGDurham, North Carolina, 27708, United States
Contact Email: •••••@•••••
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Hopp Children's Cancer Center at NCT Heidelberg (KiTZ)
NOT_YET_RECRUITINGHeidelberg, Baden-Wurttemberg, 69120, Germany
Contact Email: •••••@•••••
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Montreal Children's Hospital
NOT_YET_RECRUITINGMontreal, Quebec, H4A3J1, Canada
Contact Email: •••••@•••••
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Nationwide Children's Hospital
NOT_YET_RECRUITINGColumbus, Ohio, 43235, United States
Contact Email: •••••@•••••
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Perth Children's Hospital
NOT_YET_RECRUITINGPerth, Western Australia, 6000, Australia
Contact Email: •••••@•••••
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Princess Máxima Center
NOT_YET_RECRUITINGUtrecht, 3720, Netherlands
Contact Email: •••••@•••••
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Queensland Children's Hospital
NOT_YET_RECRUITINGSouth Brisbane, Queensland, 4101, Australia
Contact Email: •••••@•••••
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Seattle Children's Hospital
NOT_YET_RECRUITINGSeattle, Washington, 98105, United States
Contact Email: •••••@•••••
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Starship Children's Hospital
NOT_YET_RECRUITINGAuckland, Grafton, 1023, New Zealand
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sydney Children's Hospital
NOT_YET_RECRUITINGRandwick, New South Wales, 2031, Australia
Contact Email: •••••@•••••
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Texas Children's Hospital
NOT_YET_RECRUITINGHouston, Texas, 77030, United States
Contact Email: •••••@•••••
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The Hospital for Sick Children (SickKids)
NOT_YET_RECRUITINGToronto, Ontario, M5G1X8, Canada
Contact Email: •••••@•••••
Conditions
Explore the condition pages connected to this study.