GLIOBLASTOMA MULTIFORME

This early-stage study tests whether a device called TheraSphere GBM is safe for people whose glioblastoma brain tumor has come back. About 36 adults with recurrent glioblastoma will receive the treatment. The main goal is to check for serious side effects and see if the procedur…

This study tests the safety and effectiveness of giving two cancer drugs (cetuximab and bevacizumab) directly into the brain's arteries each month for children and young adults under 22 with brain tumors that have come back or not responded to treatment. About 20 participants wil…

This early-phase trial tests a personalized vaccine called Tamavaq NeoVaccine in 29 adults with newly diagnosed glioma, a type of brain cancer. The vaccine is designed using AI and quantum mechanics to target unique mutations in each patient's tumor, aiming to train the immune sy…

This study tests a new surgical technique for people with a fast-growing brain cancer called glioblastoma. During surgery to remove the tumor, doctors place a piece of the patient's own tissue (from the scalp or skull lining) into the empty space. This flap may help bypass the bl…

This study looks at whether using chemotherapy alone is as good as combining it with radiation for elderly and frail patients with a type of brain cancer called glioblastoma. About 107 participants aged 65 and older with limited mobility will be randomly assigned to one of two tr…

This study tests a drug called tarlatamab (AMG 757) given together with radiation therapy for cancers that have a protein called DLL3, such as certain lung cancers, melanomas, and brain tumors. The goal is to see if the combination is safe and helps shrink tumors. About 30 adults…

This study tests a new approach for people with a fast-growing brain cancer called glioblastoma. Doctors take some of the patient's own blood stem cells, add a protective gene (P140K MGMT), and put them back. This allows the use of stronger chemotherapy to kill more cancer cells …

This phase 3 trial tests whether delivering the drug Avastin directly into the brain's arteries (called SIACI) alongside standard chemotherapy and radiation can help people with newly diagnosed glioblastoma live longer. About 432 adults with this aggressive brain cancer will be r…

This study tests whether a ketogenic (high-fat, low-carb) diet can help people with newly diagnosed glioblastoma live longer when combined with standard treatments like chemotherapy and radiation. About 170 adults will be randomly assigned to either a ketogenic diet or a standard…

This study tests a device that delivers low-intensity magnetic waves to treat glioblastoma, an aggressive brain cancer. About 30 adults who have had surgery for newly diagnosed glioblastoma will use the device alongside standard care. The main goal is to check safety and see if t…

This study tests a new approach for people with recurrent glioblastoma, an aggressive brain cancer. It combines gene therapy (HSV-tk) with an antiviral drug, radiation, and chemotherapy to try to control the disease. The goal is to see if this combination helps people live longer…

This study tests a new way to deliver the drug Avastin directly into the brain's arteries for people with recurrent glioblastoma or anaplastic astrocytoma. The goal is to see if repeated doses are safe and can help control the tumor better than standard IV therapy. About 54 adult…

This early-stage study tests a new treatment for people whose glioblastoma brain tumor has come back. The therapy combines an investigational drug (5-ALA) with focused ultrasound waves to target and damage tumor cells before surgery. The main goals are to check safety and see if …

This study tests an experimental drug called NEO100 (perillyl alcohol) in people with a specific type of aggressive brain cancer (gliomas with an IDH1 mutation) that has come back or gotten worse. The drug is taken as a nasal spray four times a day. The study has two parts: first…

This study tests whether adding a focused ultrasound device (NaviFUS) to the standard drug Avastin helps people with recurrent glioblastoma (a type of aggressive brain cancer) live longer without their cancer growing. About 32 adults whose cancer returned after standard treatment…

This trial tests a new way to treat glioblastoma, an aggressive brain cancer. A device placed in the skull uses ultrasound to temporarily open the blood-brain barrier, allowing immune-boosting drugs to reach the tumor more effectively. The study involves 25 adults who have comple…

This study tests a new approach for people with a returning, aggressive brain cancer called glioblastoma. Doctors take a piece of tissue from the patient's belly and place it into the brain during surgery to remove the tumor. The goal is to see if this is safe and might help deli…

This early-phase study tests a new approach for people with recurrent high-grade astrocytomas, a type of aggressive brain cancer. Participants will receive a special virus injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the …

This early-stage trial is for adults with newly diagnosed glioblastoma, a serious brain cancer. It tests a combination of a chemotherapy wafer placed during surgery, an immunotherapy drug, and radiation, with or without another chemo drug. The main goals are to check safety and f…

This study tests whether adding APG-157 (a daily dissolvable pastille) to standard bevacizumab can help people with recurrent high-grade glioma live longer and feel better. About 30 participants will take six pastilles each day alongside their regular treatment. Researchers will …

This study tests the drug lorlatinib in children (ages 1-21) with newly diagnosed high-grade glioma that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor and to check its safety when given alone or with chemotherap…

This early-phase study tests whether a specially engineered virus called G207 is safe for children whose cerebellar brain tumors have come back or not responded to standard treatments. Up to 24 children aged 3 to 21 will receive the virus directly into the tumor, along with a low…

This study tests whether adding the drug ruxolitinib to standard treatment (radiation and temozolomide) helps people with newly diagnosed glioblastoma live longer. About 190 adults will be randomly assigned to receive either the standard treatment alone or standard treatment plus…

This early-phase study tests a new treatment for aggressive brain tumors (glioblastoma and pediatric high-grade gliomas). The therapy uses a patient's own immune cells, modified to target a protein called CD70 on tumor cells and to better reach the brain. The main goals are to ch…

This early-phase study tests whether combining targeted radiation with an immunotherapy drug (atezolizumab) before surgery can help control glioblastoma, an aggressive brain cancer. Twelve newly diagnosed patients will receive two weeks of treatment, then undergo standard surgery…

This study tests whether adding two different drug combinations after radiation can help children and young adults (up to age 21) with high-grade gliomas, including DIPG, live longer. One group receives ribociclib plus everolimus; another gets ribociclib plus temozolomide. The go…

This study tests whether combining an immunotherapy drug (pembrolizumab) with targeted radiation before surgery is safe and can help people with recurrent glioblastoma, an aggressive brain cancer. About 10 adults whose tumor has returned after prior treatment will receive this co…

This early-stage study tests whether combining a standard brain cancer drug (bevacizumab) with focused ultrasound can safely treat recurrent glioblastoma, an aggressive brain tumor. About 10 adults whose cancer has returned after standard therapy will receive the combination. The…

This study tests a new drug called LMP744 in 40 adults whose glioblastoma (a type of brain cancer) has come back after standard treatment. The drug is given through a vein for 5 days each month for up to a year. The goal is to see if it can shrink tumors or slow the cancer's grow…

This study tests a new treatment for people with aggressive brain tumors like glioblastoma. It combines an immunotherapy drug (pembrolizumab) with a genetically modified herpes virus (M032) that is designed to infect and kill cancer cells while boosting the immune system. The goa…

This early-stage study tests the safety of a new treatment for glioblastoma, an aggressive brain cancer that has come back. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack the cancer, then delivered directly into the fluid ar…

This early-stage study tests a new radioactive drug (131I-TLX101) given alongside standard treatment for people with newly diagnosed glioblastoma, an aggressive brain cancer. The main goal is to find the safest dose and check for side effects. About 12 adults who have had surgery…

This study tests a new, noninvasive technique called sonobiopsy that uses ultrasound to release tumor DNA into the bloodstream, making it easier to detect and monitor glioblastoma. About 40 adults with suspected glioblastoma will receive sonobiopsy before standard surgery. The go…

This study collects samples of glioblastoma (a type of brain tumor) and blood from 120 adults during standard surgery. Researchers will examine different parts of the same tumor to see how they differ at the genetic level. The goal is to learn more about how the tumor works, whic…

This study tests whether adding a special PET scan (FET-PET) to standard MRI can better guide surgery and radiation for glioblastoma, the most aggressive brain tumor. About 189 adults with a single tumor will be randomly assigned to have treatment planning based on MRI alone or M…

This study aims to improve how doctors see brain tumors using a special MRI and PET scan. Researchers will compare scan images with tumor tissue samples to better understand tumor metabolism. The study involves 50 adults with glioblastoma who need surgery. This is an observationa…

This study tests whether special MRI scans can spot low-oxygen (hypoxic) areas in glioblastoma, an aggressive brain cancer. Twenty adults with suspected glioblastoma will get two types of MRI scans to map these areas. The goal is to see if these scans can help doctors deliver mor…

This study tests a new, wearable loupe that helps surgeons see brain tumor tissue during surgery using a special dye. The goal is to see if this small, low-cost device works as well as a large microscope to guide tumor removal. The study will enroll 30 adults with glioblastoma or…

This study aims to analyze the genetic makeup of brain tumors in 350 children, adolescents, and young adults newly diagnosed with high-grade glioma or diffuse intrinsic pontine glioma. By identifying specific genetic changes, researchers hope to match patients with targeted treat…

This study looks at whether measuring two proteins (VEGF and MMP) in blood and urine can help predict if a glioblastoma brain tumor will come back within a year after radiation therapy. About 200 adults with this type of brain tumor will provide samples before, during, and after …