GLIOBLASTOMA MULTIFORME

This small pilot study tested a new approach for people with recurrent glioblastoma, an aggressive brain cancer that has come back after standard treatments. Six adults received a combination of focused ultrasound (NaviFUS) and the standard drug bevacizumab. The goal was to see i…

This study tested a new surgical technique in 12 people with a fast-growing brain cancer called glioblastoma. Doctors placed a piece of the patient's own tissue into the area where the tumor was removed to bypass the brain's protective barrier. The goal was to see if the procedur…

This early-phase study tested a new drug called tinostamustine in 10 people with a fast-growing brain cancer (glioblastoma) that has a specific genetic marker (unmethylated MGMT). The goal was to see if the drug is safe and to find the best dose after standard treatment. The drug…

This study tested the safety and highest tolerable dose of a second round of radiation for people whose glioblastoma (a type of brain tumor) came back after initial treatment. Seventeen adults aged 18 to 50 with good overall health took part. The goal was to find a dose that cont…

This study looked at whether a modified Atkins diet combined with short-term fasting is possible for people with glioblastoma, an aggressive brain cancer. Twenty-five patients who had already completed standard treatment tried the diet for 8 weeks. The main goal was to see if the…

This early-phase study tested a drug called INCB7839 in 13 children whose high-grade gliomas (aggressive brain tumors) had come back or worsened. The main goal was to find a safe dose and check for side effects. The drug works by blocking a protein that helps tumors grow. This tr…

This study tested a device called Optune, which delivers electric fields to the brain, alongside radiation and chemotherapy for people newly diagnosed with glioblastoma, an aggressive brain cancer. About 981 adults took part. The goal was to see if adding Optune to standard treat…

This study tested the drug pamiparib, alone or with radiation, in 50 people with glioblastoma (a fast-growing brain cancer). It included both newly diagnosed and recurrent cases. The goal was to see how well the drug reaches the tumor and whether it helps control the disease. Thi…

This study tested a drug called VAL-083 combined with standard radiation in 29 adults with a newly diagnosed aggressive brain cancer (glioblastoma) that has a specific genetic marker (unmethylated MGMT). The goal was to find a safe dose and see if the treatment shrinks tumors. Th…

This early-phase study tested whether adding a drug called chlorpromazine (an older medication used for mental health) to standard brain cancer treatment is safe for people newly diagnosed with glioblastoma, a serious brain tumor. Ten adults took part to find the best dose and ch…

This study looked at 33 adults with glioblastoma, a serious brain cancer, whose tumors grew back quickly after surgery. Researchers used a special PET scan with 11C-methionine to see the active tumor better than standard MRI. The goal was to use this extra information to plan mor…

This study tested whether a special type of scan (FET-PET/MRI) can more accurately show the full extent of glioblastoma brain tumors after surgery. The goal was to see if this scan could help doctors plan radiation treatment better than standard MRI alone. Eleven adults who had s…