GLIOBLASTOMA MULTIFORME

This early-phase study tests a new drug called DSP-0390 in about 39 adults whose high-grade glioma (a fast-growing brain tumor) has come back. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. Participants must be in fairly good h…

This study tests whether adding the experimental drug BPM31510 (with vitamin K1) to standard radiation and chemotherapy can help people with newly diagnosed glioblastoma live longer without their cancer growing. About 50 adults with this aggressive brain tumor will receive the co…

This study tests whether adding high-dose vitamin C to the usual treatment (radiation and chemotherapy) can help people with a fast-growing brain tumor called glioblastoma live longer. About 90 adults with newly diagnosed glioblastoma will receive the vitamin C infusions alongsid…

This study tests whether adding the antiviral drug valganciclovir to standard treatment can help people with glioblastoma, an aggressive brain cancer. The drug targets a common virus (CMV) found in most glioblastoma tumors, which may make the cancer more aggressive. About 220 adu…

This study aimed to test an experimental virus therapy (G207) injected directly into the brain tumor, combined with a single dose of radiation, in children whose high-grade glioma had come back after standard treatment. The goal was to see if this approach could help children liv…

This trial aimed to test a new treatment for adults with a recurring, aggressive brain cancer called glioblastoma. The therapy used special immune cells (CYNK-001) combined with a protein (IL-2) to help fight the tumor. The study was withdrawn before any participants were enrolle…

This early-phase trial tests a drug called ACP-196 (acalabrutinib) in 24 adults whose glioblastoma (a fast-growing brain cancer) has come back after standard treatment. The goal is to see if the drug can shrink tumors or stop them from growing. Participants must have had prior ch…

This study tests whether adding the drug AZD1390 to standard radiation therapy can help control grade 4 gliomas, a fast-growing brain cancer. About 97 participants with either new or recurrent tumors will receive the drug and radiation. The goal is to see if the drug reaches the …

This study looks at whether the drug ribociclib can reach and build up in brain tumors. About 48 adults with recurrent high-grade glioma or meningioma will take the drug before their scheduled tumor removal surgery. The goal is to measure how much drug gets into the tumor and spi…

This early-phase study tests whether taking a piece of tissue from the belly and placing it in the brain after removing a recurrent glioblastoma tumor is safe. The tissue flap may help bypass the blood-brain barrier to allow better treatment. Ten adults with recurrent glioblastom…

This study tests whether adding an experimental drug called NanO2 to standard radiation and chemotherapy can help people with newly diagnosed glioblastoma, an aggressive brain cancer. NanO2 is designed to deliver more oxygen to tumors, which may make radiation more effective. Abo…

This trial tests an implantable ultrasound device that temporarily opens the blood-brain barrier, allowing chemotherapy to reach brain tumors. It includes 57 adults with recurrent glioblastoma who have already tried 1-2 treatments. The goal is to find a safe dose and see if this …

This study tests a vaccine called SurVaxM in 35 children whose brain tumors have come back or are hard to treat. The vaccine teaches the body's immune system to find and destroy cancer cells that have a protein called survivin. The goal is to see if it is safe and can help contro…

This early-stage study tests a genetically engineered virus (rQNestin34.5v.2) that is injected directly into recurrent brain tumors to see if it is safe and what dose works best. About 62 adults with certain types of brain cancer that have come back or worsened are taking part. T…

This study tests a drug called pazopanib added to standard chemotherapy (temozolomide) for people with newly diagnosed glioblastoma, a fast-growing brain tumor. The goal is to find a safe dose and see if the combination helps control the disease after surgery and radiation. About…

This early-phase trial tests the drug niraparib in people with two types of brain tumors: newly diagnosed glioblastoma and recurrent IDH-mutant glioma with ATRX loss. The study first checks if the drug reaches the tumor and affects cancer cells, then gives more doses to those who…

This early-stage trial tests whether giving two immunotherapy drugs (nivolumab and ipilimumab) before surgery can help the immune system fight recurrent glioblastoma, an aggressive brain cancer. About 63 adults whose tumor has returned after standard treatment will receive the dr…

This early-stage trial tests a new treatment for glioblastoma that has come back after initial therapy. It combines precise radiation (stereotactic radiosurgery) with two immunotherapy drugs that help the immune system attack cancer cells. The study involves 16 adults and primari…

This early-phase trial tests whether adding high-dose vitamin C and an iron-based drug (ferumoxytol) to standard radiation and chemotherapy can help adults with a newly diagnosed aggressive brain tumor called glioblastoma. The study involves 17 participants and aims to find the s…

This study tests whether adding the experimental drug LAM561 to standard radiation and chemotherapy can help people with newly diagnosed glioblastoma, a fast-growing brain tumor. About 144 adults aged 18 to 75 will receive either LAM561 or a placebo alongside their usual treatmen…

This program provides an experimental drug called gallium maltolate (GaM) to adults with glioblastoma that has come back or not responded to treatment. It is for patients who have run out of standard therapies. The goal is to see if GaM can help control the disease, but it is not…

This study tests a new treatment called Temferon for people with glioblastoma, a fast-growing brain cancer. The therapy uses a patient's own blood stem cells, modified to deliver interferon directly to the tumor. Up to 27 patients with a specific genetic marker (unmethylated MGMT…

This early-stage trial tested the safety and best dose of a drug called APX005M in 32 children with brain tumors that had come back or were hard to treat, including a type of brain stem glioma. The drug works by activating the immune system to attack tumor cells. The main goals w…

This early-phase study tests whether adding the experimental drug S-Gboxin to standard radiation and chemotherapy can help people with glioblastoma or diffuse midline glioma, two aggressive brain cancers. About 10 participants whose tumors have returned or worsened will receive t…

This study tests a new way to deliver two cancer drugs (bevacizumab and carboplatin) directly to the brain through an artery for people with recurrent glioblastoma or anaplastic astrocytoma. The goal is to see if repeated doses are safe and can shrink tumors or slow their growth …

This study tests whether giving a higher radiation dose to a brain area called the subventricular zone (where stem cells live) can delay glioblastoma from coming back. About 60 adults with newly diagnosed glioblastoma will receive standard radiation and chemo, but half will get e…

This study tests a new drug called ST101 in people with advanced solid tumors that cannot be removed by surgery or have spread. The goal is to find a safe dose and see if the drug can shrink tumors. About 125 adults with cancers like glioblastoma, melanoma, breast, or prostate ca…

This study aimed to see if a diet low in certain amino acids (cysteine and methionine) could change how the body and brain tumor cells work in patients with recurrent glioma. Up to 30 patients were to be randomly assigned to either a regular diet or the special diet for 2 to 7 da…