Electric field therapy shows promise in brain cancer battle

NCT ID NCT04471844

Completed Disease control Sponsor: NovoCure Ltd. Source: ClinicalTrials.gov ↗

First seen Apr 06, 2026 · Last updated Apr 24, 2026 · Updated 2 times

Summary

This study tested a device called Optune that delivers electric fields to the brain, combined with standard radiation and chemotherapy, in 981 people with newly diagnosed glioblastoma. The goal was to see if adding Optune helps people live longer and keeps the cancer from growing. Participants received either standard treatment alone or standard treatment plus Optune, and both groups continued maintenance therapy after radiation.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

Abbott Northwestern Hospital - Givens Brain Tumor Center

Minneapolis, Minnesota, 55407, United States
AdventHealth

Orlando, Florida, 32804, United States
Allegheny Health Network Cancer Institute

Pittsburgh, Pennsylvania, 15212, United States
BC Cancer - Vancouver

Vancouver, British Columbia, V5Z 4E6, Canada
Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States
Baptist Health - Jacksonville

Jacksonville, Florida, 32207, United States
Baylor Charles A. Sammons Cancer Center - Baylor University Medical Center

Dallas, Texas, 75246, United States
Baylor Scott & White Medical Center

Temple, Texas, 76508, United States
CHUM Centre de Recherche

Montreal, Quebec, H2X1R9, Canada
Cedars - Sinai Medical Center

Los Angeles, California, 90048, United States
Charing Cross Hospital

London, W6 8RF, United Kingdom
Charité Campus Virchow Clinic

Berlin, 13353, Germany
City of Hope National Medical Center

Duarte, California, 91010, United States
Clatterbridge Cancer Centre

Liverpool, L7 8YA, United Kingdom
Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Forsyth Medical Center-Novant Health

Winston-Salem, North Carolina, 27103, United States
Grandview Cancer Center

Birmingham, Alabama, 35243, United States
Gustave Roussy Institute

Villejuif, 94805, France
Guy's Hospital

London, SE1 9RT, United Kingdom
H. Lee Moffitt Cancer Center and Research Institute, Inc

Tampa, Florida, 33612, United States
HCA Research Institute - Blue Sky Neurology - Denver

Englewood, Colorado, 80113, United States
Hackensack University Medical Center - John Theurer Cancer Center

Hackensack, New Jersey, 07601, United States
Hadassah Medical Center - Ein Kerem

Jerusalem, 9112001, Israel
Hartford Healthcare Medical Group - Hartford Hospital The Gray Cancer Center

Hartford, Connecticut, 06106, United States
Health Midwest Ventures Group, Inc - Sarah Cannon HCA Midwest Brain and Spine

Kansas City, Missouri, 64132, United States
Highlands Oncology Group

Fayetteville, Arkansas, 72762, United States
Hoag Memorial Hospital - Hoag Cancer Center

Newport Beach, California, 92663, United States
Hokkaido University Hospital

Sapporo, Hokkaido, 060-8648, Japan
Hospital Erasme

Brussels, 1070, Belgium
Houston Methodist Hospital

Houston, Texas, 77030, United States
Hôpital la Timone

Marseille, 13305, France
Innsbruck University Hospital

Innsbruck, Innsbruck, 6020, Austria
Institut de cancérologie de l'Ouest

Angers, 49055, France
Institut de cancérologie de l'Ouest

Saint-Herblain, 44800, France
JFK Neuroscience Institute, HMH JFK University Medical Center

Edison, New Jersey, 08820, United States
Jersey Shore University Medical Center

Neptune City, New Jersey, 07753, United States
John Hopkins School of Medicine

Baltimore, Maryland, 21287, United States
John Peter Smith Health Network - JPS Cancer Center

Fort Worth, Texas, 76104, United States
John Wayne Cancer Institute at St. John's Health Center

Santa Monica, California, 90404, United States
Kanazawa University Hospital

Kanazawa, Ishikawa-ken, 920-8641, Japan
Kepler University Hospital

Linz, Linz, 4020, Austria
Kyorin University Hospital

Mitaka-shi, Tokyo-To, 181-8611, Japan
LSU Health Sciences Center, New Orleans

New Orleans, Louisiana, 70072, United States
Lausanne University Hospital

Lausanne, CH-1011, Switzerland
Lynn Cancer Institute, Marcus Neuroscience Institute

Boca Raton, Florida, 33486, United States
MUSC Radiation Oncology Brain & Spine Tumor Program

Charleston, South Carolina, 29425, United States
Maine Medical Partners Neurology - Neurosurgery & Spine Associates

South Portland, Maine, 04106, United States
Mary Bird Cancer Center Neuromedical Center

Baton Rouge, Louisiana, 70810, United States
Masaryk Memorial Cancer Institute

Brno, Brno, 656 53, Czechia
Massey Cancer Center - VCU Medical Center

Richmond, Virginia, 23298, United States
Mayo Clinic

Jacksonville, Florida, 32224, United States
Mayo Clinic- Arizona

Phoenix, Arizona, 85054, United States
Mount Sinai - Icahn School of Medicine

New York, New York, 10029, United States
NYU Langone - Laura & Issac Perimutter Cancer Center

New York, New York, 10016, United States
Na Homolce Hospital

Prague, Prague, 150 30, Czechia
Neuroscience Center, Philadelphia - University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
New York Presbyterian - Columbia University

New York, New York, 10032, United States
Norris Comprehensive Cancer Center at USC

Los Angeles, California, 90033, United States
Northside Hospital, Inc.

Atlanta, Georgia, 30342, United States
Northwell Health System Brain Tumor Center

Lake Success, New York, 11042, United States
Norton Cancer Institute

Louisville, Kentucky, 40241, United States
Nottingham University Hospitals NHS Trust

Nottingham, NG5 1PB, United Kingdom
Nova Scotia Health Authority

Sydney, Nova Scotia, B1P 1P3, Canada
Novant Health Cancer Institute Radiation Oncology

Charlotte, North Carolina, 28204, United States
Ochsner Health System

New Orleans, Louisiana, 70121-2429, United States
Oregon Health & Science University (OHSU)

Portland, Oregon, 97239, United States
Orlando Health UF Health Cancer Center

Orlando, Florida, 32806, United States
Parkview Cancer Institute - Fort Wayne Radiation Oncology Associates

Fort Wayne, Indiana, 46845, United States
Piedmont Healthcare Brain Tumor Center

Atlanta, Georgia, 30309, United States
Pierre Wertheimer Hospital

Bron, 69677, France
Pitié-Salpêtrière University Hospital

Paris, 75013, France
Princess Margaret Cancer Centre

Toronto, Ontario, Canada
Providence St. Joseph Medical Center and The Roy and Patricia Disney Family Cancer Center

Burbank, California, 91505, United States
Rabin Medical Center

Petah Tikva, Petah Tikva, 49100, Israel
Rambam Medical Center

Haifa, Haifa District, 3109601, Israel
Rechts der Isar Hospital

Munich, 81675, Germany
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
Royal Preston Hospital

Preston, PR29HT, United Kingdom
Rush University Medical Center

Chicago, Illinois, 60612, United States
SCRI - Tennessee Oncology

Chattanooga, Tennessee, 37404, United States
SCRI - Tennessee Oncology

Nashville, Tennessee, 37203, United States
SUNY Upstate Medical University

Syracuse, New York, 13210, United States
Saitama Medical University International Medical Center

Hidaka-shi, Saitama, 350-1298, Japan
Sharp Memorial Hospital - X-Ray Medical Group Radiation Oncology

San Diego, California, 92123, United States
Sheba Medical Center

Ramat Gan, Ramat Gan, 52621, Israel
St. Joseph Hospital of Orange

Orange, California, 92868, United States
Stanford University Cancer Institute

Palo Alto, California, 94303, United States
Sunnybrook Research Institute - Odette Cancer Centre

Toronto, Ontario, Canada
Swedish Health Services

Seattle, Washington, 98122, United States
TRIO - St. Jude Heritage Healthcare/St. Jude Medical Center

Fullerton, California, 92835, United States
Tel Aviv Sourasky Medical Center

Tel Aviv, Tel Aviv, 64239, Israel
Texas Oncology Midtown - Austin Brain Tumor Center

Austin, Texas, 78705, United States
The Emory Clinic - Emory Healthcare - Winship Cancer Institute

Atlanta, Georgia, 30322, United States
The James Cancer Hospital and Solove Research Institute - Arthur G James Cancer Hospital

Columbus, Ohio, 43210, United States
The Ottawa Hospital Cancer Centre

Ottawa, Ontario, Canada
The University of Kansas Cancer Center

Topeka, Kansas, 66606, United States
The University of Vermont Medical Center - University of Vermont Cancer Center

Burlington, Vermont, 05401, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
Tokyo Women's Medical University Hospital

Shinjuku-ku, Tokyo-To, 162-8666, Japan
Tufts Medical Center

Boston, Massachusetts, 02111, United States
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
UT Health Mischer Neuroscience - Memorial Herman - UT Neurosciences

Houston, Texas, 77030, United States
UW Medical Center - Alvord Brain Tumor Center

Seattle, Washington, 98109, United States
Universite de Sherbrooke - Sherbrooke Centre Hospitalier Universita

Sherbrooke, Quebec, Canada
University Hospital Essen

Essen, 45147, Germany
University Hospital Leipzig

Leipzig, 04103, Germany
University Hospital Liege - Sart Tilman

Liège, B35, 4000, Belgium
University Hospital Nice

Nice, 06000, France
University Hospital Plzeň

Pilsen, Pilsen, 305 99, Czechia
University Hospital Salzburg

Salzburg, State of Salzburg, 5020, Austria
University Hospital Tübingen

Tübingen, 72076, Germany
University Hospital Zurich

Zurich, 8091, Switzerland
University Institute Cancer Toulouse Oncopole

Toulouse, 31059, France
University Medical Center Freiburg

Freiburg im Breisgau, 79106, Germany
University of Arizona Cancer Center

Tucson, Arizona, 85719, United States
University of California - Irvine/UCI Medical Center

Orange, California, 92868, United States
University of California San Francisco Medical Center

San Francisco, California, 94143, United States
University of California at San Diego - Moores Cancer Center

La Jolla, California, 92093, United States
University of Chicago

Chicago, Illinois, 60617, United States
University of Cincinnati Cancer Institute

Cincinnati, Ohio, 45219, United States
University of Colorado Cancer Center Anschutz

Aurora, Colorado, 80045, United States
University of Louisville - James Graham Brown Cancer Center

Louisville, Kentucky, 40202, United States
University of Massachusetts Chan Medical School

Worcester, Massachusetts, 01655, United States
University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Missouri - Ellis Fischel Cancer Center

Columbia, Missouri, 65212, United States
University of North Carolina Brain Tumor Program - UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
University of Rochester Medical Center

Rochester, New York, 14642, United States
Vidant Medical Center

Greenville, North Carolina, 27834, United States
Wake Forest Baptist Comprehensive Cancer Center

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
West Cancer Center - Germantown

Germantown, Tennessee, 38138, United States
West Virginia University Cancer Institute

Morgantown, West Virginia, 26506, United States

Conditions

Explore the condition pages connected to this study.

GLIOBLASTOMA MULTIFORME