Brain cancer breakthrough? GammaTile trial aims to boost survival

NCT ID NCT07195591

Recruiting now Disease control Sponsor: GT Medical Technologies, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 4 times

Summary

This Phase 3 trial tests whether adding a special radiation tile (GammaTile) during brain surgery improves survival for people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 766 participants will be randomly assigned to standard treatment (surgery, radiation, and chemo) or standard treatment plus GammaTile. The study is currently recruiting and will compare overall survival between the two groups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GammaTile (radiation-emitting tiles placed during surgery), external beam radiation, and temozolomide chemotherapy
What this could lead to: If successful, this could offer a more effective way to control glioblastoma by delivering radiation directly to the tumor site during surgery, potentially extending survival.
What could go wrong: This is an early-stage Phase 3 trial, and results may not confirm a benefit. Adding GammaTile could increase side effects like brain swelling or infection, and the treatment still requires ongoing chemotherapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioblastoma neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA

Contacts and locations

Locations

Allegheny Health Network
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Brown University Health
RECRUITING

Providence, Rhode Island, 02903, United States
East Carolina University
RECRUITING

Greenville, North Carolina, 27834, United States
HonorHealth Scottsdale Osborn Medical Center
RECRUITING

Scottsdale, Arizona, 85251, United States
Jersey Shore University Medical Center | Hackensack
RECRUITING

Neptune City, New Jersey, 07753, United States
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21287, United States
Westchester Medical Center
RECRUITING

Valhalla, New York, 10595, United States

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