GLIOBLASTOMA

This study tests whether adding a drug called ADI-PEG 20 to standard radiation and chemotherapy can help children, teens, and young adults with newly diagnosed high-grade glioma (a fast-growing brain tumor). About 97 participants will receive the combination therapy. The goal is …

This early-phase trial tests a custom-made vaccine (Bvax) designed to train the immune system to fight glioblastoma, a fast-growing brain tumor. About 25 people with newly diagnosed glioblastoma will receive the vaccine alongside standard chemotherapy and radiation. The main goal…

This study tests whether a special MRI scan (called CEST) can help surgeons see and remove more glioblastoma tumor tissue during surgery than standard methods. About 60 adults with newly diagnosed glioblastoma will be randomly assigned to either CEST-guided surgery or standard su…

This early-phase study tests whether using focused ultrasound to open the blood-brain barrier can help the immunotherapy drug pembrolizumab work better against a returning, aggressive type of brain cancer called glioblastoma. The study will include 8 adults whose tumors have a sp…

This study tests a new approach for people with recurrent glioblastoma, an aggressive brain cancer. It combines a laser treatment that heats and destroys tumor tissue with an immunotherapy drug (cemiplimab) that helps the immune system fight cancer. The study compares this combin…

This early-phase study tests a new drug called MT-125 given alongside standard chemoradiation for people newly diagnosed with a specific type of glioblastoma (MGMT methylated). The main goals are to check safety, find the best dose, and see how the drug behaves in the body. About…

This study tests a personalized vaccine (ZSNeo-DC1.1) made from a patient's own immune cells, combined with standard chemotherapy, for people with newly diagnosed glioblastoma. The goal is to see if the vaccine helps keep the cancer from growing back longer than chemotherapy alon…

This study tests giving chemotherapy before radiation for people with high-grade gliomas, an aggressive brain cancer. The goal is to see if this order makes it easier to read MRI scans and find effective drugs faster. About 70 adults aged 18-80 with measurable tumor after surgery…

This early-phase trial tests whether sitagliptin, a common diabetes medicine, can help treat a severe type of brain cancer (grade 4 glioma) that has returned after standard treatment. About 45 adults will receive sitagliptin along with the standard drug bevacizumab. The study aim…

This study tests a new approach called pharmacoscopy, which uses a lab test on a patient's tumor sample to find the most effective drugs for their specific cancer. It involves 40 adults with brain tumors like glioblastoma that have not responded to standard treatments. The goal i…

This study tests two experimental drugs, CTX-009 and CTX-471, in people whose glioblastoma has returned after standard treatment. The goal is to see if these drugs are safe and can help control the tumor or extend survival. About 54 participants will receive either CTX-009 alone …

This phase 2 trial tests whether placing tiny chemotherapy-releasing seeds directly into the brain after tumor removal can help control glioblastoma, an aggressive brain cancer. About 147 adults with either recurrent or newly diagnosed glioblastoma will receive the seeds plus sta…

This phase II trial tests whether vortioxetine, a drug currently used for depression, can help people with newly diagnosed glioblastoma. The study will enroll 78 adults and measure if the drug extends the time before the cancer worsens. Vortioxetine was selected because lab tests…

This early-phase study tests a fluorescent dye called panitumumab-IRDye800 to see if it can help surgeons spot brain tumors during surgery. The dye is designed to attach to cancer cells and glow under a special camera. About 30 adults with brain tumors like meningioma or glioblas…

This early-stage study tests whether a special MRI that highlights acidic areas can help surgeons see and remove more of an aggressive brain tumor called glioblastoma. The study involves 12 VA patients with newly diagnosed or recurrent glioblastoma. The main goal is to check if t…

This study tests whether using MRI scans to plan radiotherapy is better than using CT scans alone. Researchers will work with up to 150 cancer patients and 15 healthy volunteers to see if MRI can make treatment more precise and reduce side effects. The goal is to improve how tumo…

This study tests whether special MRI scans can spot brain tumor cells that have spread into nearby healthy-looking tissue. About 20 adults with suspected high-grade glioma will get extra scans before surgery. The goal is to create a map showing where tumor cells hide, which could…

This very early study will give 8 adults with recurrent glioblastoma an oral gallium maltolate pill before surgery. Researchers will measure how much gallium gets into the tumor tissue compared to untreated samples. The goal is to see if the drug can reach the brain, not to treat…

This early-phase trial will test how Acetadote, a drug that affects cell damage, changes metabolism in people with newly diagnosed glioblastoma. Ten participants will receive Acetadote before surgery, and researchers will use MRI scans and tumor tissue analysis to measure metabol…

This early study tests if a new device can safely collect small fluid samples from the brain during planned surgery for glioma (a type of brain tumor) or epilepsy. Only 6 people will take part. The goal is to see if the device works and is safe, not to treat the disease.

This study will follow 100 adults with glioblastoma, an aggressive brain tumor, to understand which factors influence survival and quality of life. Researchers will collect data on patient characteristics, imaging, surgery type, and outcomes. The goal is to identify the best surg…

This study aims to understand why glioblastoma, an aggressive brain cancer, returns after treatment. Researchers will analyze blood and tumor samples from 45 adults having surgery for newly diagnosed or recurrent glioblastoma. The goal is to identify new targets for better therap…

This study tests a new way to give radiation for gliomas, a type of brain tumor. Instead of a fixed dose, doctors will use MRI and PET scans taken during treatment to adjust the radiation to target resistant areas and protect healthy tissue, guided by artificial intelligence. The…

This study looks at how glioblastoma, a serious brain cancer, changes the way brain cells communicate and use energy. Researchers will use special scans (PET and MRI) to see these changes and link them to thinking and memory problems. 80 adults with glioblastoma will be scanned b…

This study looks at how the immune system changes in 17 adults with glioblastoma, a serious brain cancer, during standard treatment with surgery and chemoradiotherapy. Researchers will measure immune cells and signals in the blood over 6 months. The goal is to understand the body…

This study aims to understand how the amount of tumor removed during surgery affects survival in people with glioblastoma, a fast-growing brain cancer. Researchers will follow 50 adults who have had surgery and standard chemo-radiation therapy. The goal is to find out which treat…

This study looks at 30 adults newly diagnosed with glioblastoma, a serious brain tumor. Researchers want to see if special MRI scans and simple blood tests can reveal important details about the tumor's biology. The goal is to find patterns that could help doctors better understa…