GLIOBLASTOMA

This early-phase study tests whether adding the experimental drug azeliragon to standard radiation and chemotherapy (temozolomide) is safe for people with newly diagnosed glioblastoma, an aggressive brain cancer. About 18 participants will receive the combination to find the best…

This phase 2 trial tests a combination of two drugs, L19TNF and lomustine, in 90 adults with glioblastoma that has come back or worsened. The goal is to find the safest and most effective dose by monitoring side effects and survival. Participants must have confirmed glioblastoma …

This study tests a combination of a drug (niraparib) and a device that delivers low-intensity electric fields (Tumor-Treating Fields) in 30 adults whose glioblastoma has come back after radiation. The goal is to see if the treatment can shrink or stabilize the tumor and to check …

This early-phase study tests a new treatment for glioblastoma, a fast-growing brain tumor. The therapy uses a patient's own immune cells, modified to target a protein called CD70 on tumor cells and to better reach the brain. The main goals are to see if the treatment is safe and …

This early-stage study tests a radioactive drug called [177Lu]Lu-DOTA-TATE in people with glioblastoma, an aggressive brain cancer. For newly diagnosed patients, the drug is given alongside standard radiation and chemotherapy. For those whose cancer has returned, it is given alon…

This early-phase study tests a modified herpes virus designed to attack brain tumor cells directly. The virus is injected into the tumor, and some participants also receive a drug to boost the immune response. The main goal is to find the safest dose and see how the body reacts. …

This phase 2 trial tests whether the immunotherapy drug nivolumab can stop or slow the growth of IDH-mutant gliomas, a type of brain tumor. The study includes 62 adults whose tumors have a high number of mutations (hypermutator phenotype) or not. Participants receive nivolumab in…

This early-phase study tests whether adding high-dose vitamin C and an iron-based drug (ferumoxytol) to standard radiation and chemotherapy can help control glioblastoma, an aggressive brain tumor. About 17 adults with newly diagnosed glioblastoma will receive these added treatme…

This early-stage trial tests a new approach for people with newly diagnosed glioblastoma, a fast-growing brain cancer. The treatment combines two DNA vaccines (INO-5401 and INO-9012) with an immunotherapy drug (cemiplimab), plus standard radiation and chemotherapy. The goal is to…

This study explores whether adding weekly MRI scans during radiation treatment for high-grade glioma (a fast-growing brain tumor) can help doctors adjust the radiation plan to better target the tumor. About 20 adults with newly diagnosed glioma will receive standard radiation plu…