GLIOBLASTOMA

This early-phase study tests a personalized vaccine made from each patient's unique tumor mutations, combined with radiation and an immunotherapy drug (pembrolizumab), for people with newly diagnosed glioblastoma. The goal is to see if the vaccine is safe and can trigger the immu…

This early-stage study tested a personalized DNA vaccine in 9 people with a fast-growing brain cancer called glioblastoma. The vaccine was custom-made for each person based on their tumor's unique features. The main goals were to see if the vaccine was safe, possible to make in t…

This study tests a vaccine called SurVaxM, given with standard chemotherapy, for people with a newly diagnosed aggressive brain cancer (glioblastoma). The vaccine is designed to train the immune system to attack cancer cells. The main goal is to see if adding the vaccine helps ke…

This study tests whether adding the experimental drug BPM31510 (with vitamin K1) to standard radiation and chemotherapy can help people with newly diagnosed glioblastoma live longer without their cancer growing. About 50 adults with this aggressive brain tumor will receive the co…

This early-stage study tests whether adding an experimental drug called OKN-007 to standard chemotherapy and radiation is safe for people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 27 adults who have had surgery for their tumor will receive the combinat…

This study tests whether adding the immunotherapy drug nivolumab to repeat radiation and another drug (bevacizumab) can help people with a returning type of aggressive brain cancer called glioblastoma. The trial includes 39 adults whose tumors have a specific genetic marker (MGMT…

This study tested the drug trametinib in 4 people with advanced cancers that have GNAQ or GNA11 gene mutations. Trametinib blocks certain proteins that help these cancers grow. The goal was to see if the drug could shrink tumors or stop them from getting worse.

This study follows 165 children who previously took the drugs dabrafenib and/or trametinib for certain brain tumors. The goal is to see how safe these drugs are over the long term and how they affect growth, like height and weight. Participants continue their treatment and are mo…

This study tests whether adding an experimental drug called indoximod to standard chemotherapy and radiation can help children aged 3 to 21 with certain brain cancers. The drug aims to boost the body's immune system to fight tumors more effectively. The trial includes children wi…

This early-phase study tests a new treatment called B7-H3 CAR-T cell therapy for people whose glioblastoma (a fast-growing brain cancer) has come back. The therapy uses a patient's own immune cells, modified in a lab to better recognize and attack cancer cells. The main goals are…

This study tests a new treatment for people with recurrent glioblastoma, an aggressive brain cancer. The approach combines immune cells (dendritic cells) with two immunotherapy drugs (ipilimumab and nivolumab) given directly into the tumor during surgery, followed by more doses i…

This trial aimed to test a new treatment for adults with a recurring, aggressive brain cancer called glioblastoma. The therapy used special immune cells (CYNK-001) combined with a protein (IL-2) to help fight the tumor. The study was withdrawn before any participants were enrolle…

This study tests a combination of two drugs, L19TNF and lomustine, in about 90 adults whose glioblastoma has come back or worsened. The goal is to find the safest and most effective dose, and to see if it helps people live longer. Participants must have a confirmed diagnosis and …

This study tests a special type of radiation therapy that targets brain tumors while sparing the scalp to reduce side effects like wound infections. It involves 100 adults with newly diagnosed grade II to IV gliomas. The goal is to see if this approach is safer and still effectiv…

This study tests whether adding the drug AZD1390 to standard radiation therapy can help control grade 4 gliomas, a fast-growing brain cancer. About 97 participants with either new or recurrent tumors will receive the drug and radiation. The goal is to see if the drug reaches the …

This early-phase study tests a radioactive drug called [177Lu]Lu-DOTA-TATE in people with glioblastoma, an aggressive brain cancer. For newly diagnosed patients, the drug is given alongside standard radiation and chemotherapy. For those whose cancer has returned, it is given alon…

This study tests a drug called azeliragon combined with radiation therapy as an initial treatment for a type of aggressive brain cancer called glioblastoma. The trial includes 30 adults whose tumors have a specific genetic marker (MGMT unmethylated). The goal is to see if the com…

This early-phase trial tests a new drug called selinexor alongside standard radiation and chemotherapy for people with newly diagnosed glioblastoma, a fast-growing brain cancer. The main goal is to find the highest safe dose of selinexor that can be given with these treatments. A…

This early-phase study tests a combination of two immunotherapy drugs (domvanalimab and zimberelimab) in people whose glioblastoma has come back after initial treatment. The goal is to check if the drugs are safe and to see how they affect the tumor and immune system. About 46 pa…

This study tested a new drug called veliparib, given with radiation and chemotherapy, for children and young adults with a fast-growing brain tumor (high-grade glioma). The goal was to see if adding veliparib helps keep the cancer from coming back longer than standard treatment. …

This early-phase study tests whether taking a piece of tissue from the belly and placing it in the brain after removing a recurrent glioblastoma tumor is safe. The tissue flap may help bypass the blood-brain barrier to allow better treatment. Ten adults with recurrent glioblastom…

This program gives certain glioblastoma patients access to SurVaxM, a vaccine-like treatment that may help slow tumor growth and extend survival. It is for Roswell Park patients who have no other treatment options or who finished a SurVaxM study and might benefit from continued t…

This study tests whether giving a higher dose of radiation (using advanced photon or proton beams) along with the chemotherapy drug temozolomide helps people with newly diagnosed glioblastoma live longer compared to standard radiation with the same chemo. About 600 participants a…

This study tests whether adding a second chemotherapy drug, lomustine, to the standard treatment (temozolomide plus radiation) helps people with a specific type of glioblastoma (a fast-growing brain cancer). The trial includes 265 patients whose tumors have a genetic marker (MGMT…

This trial tests an implantable ultrasound device that temporarily opens the blood-brain barrier, allowing chemotherapy to reach brain tumors. It includes 57 adults with recurrent glioblastoma who have already tried 1-2 treatments. The goal is to find a safe dose and see if this …

This early-stage study tests a genetically engineered virus (rQNestin34.5v.2) that is injected directly into recurrent brain tumors to see if it is safe and what dose works best. About 62 adults with certain types of brain cancer that have come back or worsened are taking part. T…

This early-phase study tested a personalized vaccine made from each patient's unique tumor mutations, combined with standard care and Tumor Treating Fields (a device that uses electric fields to disrupt cancer growth). The goal was to see if this combination is safe and feasible …

This early-stage study tests an oral drug called gallium maltolate in 26 people whose glioblastoma (a severe brain cancer) has returned after prior treatment. The main goal is to find a safe dose and see if it can slow tumor growth. Participants take the drug by mouth and are mon…

This study tests whether starting chemotherapy earlier and continuing it longer can help adults with glioblastoma, an aggressive brain cancer, live longer. About 486 participants were randomly assigned to either the standard treatment or an intensified plan. The goal is to see if…

This study tests whether removing a wider margin of brain tissue around a glioblastoma tumor (beyond what standard surgery removes) can help patients live longer. It involves 90 adults with suspected glioblastoma who are healthy enough for surgery. The approach aims to balance be…

This study tests a combination of a drug (niraparib) and a device that delivers low-intensity electric fields (Tumor-Treating Fields) in 30 adults whose glioblastoma has returned after standard treatment. The goal is to see if this approach can control the tumor—shrinking it or k…

This study tests whether adding a special radiation tile (GammaTile) during brain tumor removal surgery, along with standard chemotherapy and radiation, is safe and feasible for people with newly diagnosed glioblastoma. About 61 adults will receive the tile at surgery, then conti…

This study tests a new treatment for people newly diagnosed with glioblastoma, a serious brain cancer. The treatment combines two experimental DNA-based drugs (INO-5401 and INO-9012) with an immunotherapy drug (cemiplimab), plus standard radiation and chemotherapy. The goal is to…

This early-phase trial tests the drug niraparib in people with two types of brain tumors: newly diagnosed glioblastoma and recurrent IDH-mutant glioma with ATRX loss. The study first checks if the drug reaches the tumor and affects cancer cells, then gives more doses to those who…

This study tests whether Tofacitinib, a drug used for arthritis, can slow tumor growth in people with recurrent glioblastoma (a type of brain cancer). About 17 adults whose cancer returned after standard treatment will take Tofacitinib pills twice daily. The goal is to see if it …

This study tests a combination of an experimental drug (paxalisib), a diabetes drug (metformin), and a high-fat, low-carbohydrate (ketogenic) diet in people with a type of brain cancer called glioblastoma. The goal is to see if this approach is safe and can slow tumor growth. The…

This early-phase study tests whether specially engineered immune cells (CART-EGFR-IL13Ra2) are safe and feasible for people with a recurrent, aggressive brain cancer called glioblastoma. About 67 adults whose tumors have returned after standard treatment will receive their own mo…

This study tested whether a low-carb, high-fat diet (ketogenic diet) could help control glioblastoma, an aggressive brain cancer. Sixteen adults who had already tried standard treatments followed the diet along with their usual care. Researchers used MRI scans to see if the diet …

This study tests whether a high-fat, low-carbohydrate (ketogenic) diet combined with the diabetes drug metformin can help people with glioblastoma, an aggressive brain cancer. The goal is to lower blood sugar, which may slow tumor growth. About 18 participants will follow the die…

This study tests a targeted therapy called abemaciclib in people whose glioblastoma (a type of brain cancer) has come back. The goal is to see how much drug reaches the tumor and whether it can slow cancer growth. About 45 adults with recurrent glioblastoma will take the drug bef…

This early-stage trial tests whether giving two immunotherapy drugs (nivolumab and ipilimumab) before surgery can help the immune system fight recurrent glioblastoma, an aggressive brain cancer. About 63 adults whose tumor has returned after standard treatment will receive the dr…

This early-phase trial tests a new immune cell therapy for people with recurrent or treatment-resistant malignant glioma, a type of brain cancer. The treatment uses the patient's own T cells, modified in the lab to recognize and attack cancer cells. The main goal is to find the s…

This study is for children and young adults (up to age 25) with a newly diagnosed, aggressive brain tumor called high-grade glioma that has a specific genetic change (BRAF V600 mutation). After standard radiation therapy, participants take two targeted pills (dabrafenib and trame…

This early-phase trial tests whether adding high-dose vitamin C and an iron-based drug (ferumoxytol) to standard radiation and chemotherapy can help adults with a newly diagnosed aggressive brain tumor called glioblastoma. The study involves 17 participants and aims to find the s…

This phase 3 trial tests whether giving a dose of radiation directly to the tumor site during surgery (intraoperative radiotherapy) can help people with a newly diagnosed aggressive brain cancer called glioblastoma live longer without their cancer growing. The study involves 314 …

This study tests whether adding a special vaccine (dendritic cell vaccine) and an immune-boosting drug (varlilumab) to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma live longer. About 43 participants will receive the vaccine and be randomly…

This study tests whether adding anlotinib hydrochloride to the standard Stupp regimen helps people with newly diagnosed glioblastoma live longer without their cancer growing. About 150 adults aged 18-75 are participating. The main goal is to see if the combination delays disease …

This study tests whether a new type of radiation therapy, which adapts during treatment to target the most aggressive parts of the tumor, can help people with newly diagnosed glioblastoma live longer. About 30 participants will receive this personalized radiation along with stand…

This study tests if the immunotherapy drug nivolumab can stop or slow the growth of certain brain tumors (gliomas) that have IDH mutations. Researchers are especially interested in tumors with many genetic changes (hypermutator phenotype). The trial involves 62 adults who receive…

This study tests whether adding the drug daratumumab to standard chemotherapy and radiation can help people with a newly diagnosed aggressive brain cancer called glioblastoma. About 16 participants will receive the combination treatment. The goal is to see if the new approach imp…

This study tests a personalized cell therapy called IGV-001 for people newly diagnosed with glioblastoma, a fast-growing brain cancer. The treatment uses the patient's own cells to target the cancer. The goal is to see if it can slow tumor growth and help people live longer. Abou…

This study tests whether adding the immunotherapy drug pembrolizumab to standard treatment (temozolomide and Tumor Treating Fields) can help people with newly diagnosed glioblastoma live longer without their cancer growing. About 40 adults with this aggressive brain tumor will re…

This study compares a short course of high-dose radiation to the standard longer course for people with glioblastoma, an aggressive brain cancer. The goal is to see if the shorter treatment works just as well at keeping patients alive while possibly causing fewer side effects. Ab…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma, an aggressive brain cancer. About 52 adults with this diagnosis will receive the combination therapy. The goal is to see …

This early-stage trial tests a new drug (BGB-290) combined with chemotherapy (temozolomide) in teens and young adults with a specific type of brain tumor (IDH-mutant glioma). The goal is to find the safest dose and check for side effects. About 78 participants with newly diagnose…

This study tests whether adding the drug veliparib to standard chemotherapy (temozolomide) helps people with a newly diagnosed, aggressive brain cancer called glioblastoma live longer. The trial includes 447 participants whose tumors have a specific genetic change (MGMT promoter …

This study tests a drug called olaparib in people with advanced cancers (like brain tumors, bile duct cancer, or other solid tumors) that have a specific gene change called IDH1 or IDH2 mutation. The drug works by blocking an enzyme that cancer cells need to grow. About 89 partic…

This study tests a new drug called vebreltinib (PLB1001) for people with a specific type of recurrent brain cancer (secondary glioblastoma with IDH mutation and ZM fusion gene). About 84 participants will either receive vebreltinib capsules or standard chemotherapy. The main goal…

This study aimed to see if adding a special virus (Toca 511) and a drug (Toca FC) to standard chemotherapy and radiation could help people with a newly diagnosed aggressive brain cancer called glioblastoma. The virus was designed to make tumor cells convert Toca FC into a cancer-…

This program provides an experimental drug called gallium maltolate (GaM) to adults with glioblastoma that has come back or not responded to treatment. It is for patients who have run out of standard therapies. The goal is to see if GaM can help control the disease, but it is not…

This early-phase study tests the safety of adding the drug ibrutinib to standard radiation and chemotherapy for people with a fast-growing brain tumor called glioblastoma. The trial includes 36 participants and looks at different dose levels based on a specific genetic marker (MG…

This early-phase trial tests whether specially engineered immune cells (IL13Rα2-CAR T cells) are safe for adults whose brain cancer (glioblastoma, ependymoma, or medulloblastoma) has spread to the lining of the brain and spinal cord. Ten participants receive these cells to see if…

This study tests a new drug called ST101 in people with advanced solid tumors that cannot be removed by surgery or have spread. The goal is to find a safe dose and see if the drug can shrink tumors. About 125 adults with cancers like glioblastoma, melanoma, breast, or prostate ca…

This early-phase trial tests whether adding mycophenolate mofetil (a drug usually used to prevent organ rejection) to standard chemotherapy and radiation can help treat glioblastoma, an aggressive brain cancer. The study involves 60 newly diagnosed or recurrent glioblastoma patie…

This early study tests a new imaging technique called qOBM that may help brain surgeons see tumor edges more clearly during surgery. About 24 adults with certain brain tumors (glioblastoma, astrocytoma, or oligodendroglioma) will have the device used during their planned tumor re…

This study tests whether an online mind-body program for couples can improve quality of life for people with brain tumors (glioma or metastatic brain cancer) and their partners. About 74 couples will take part. The program focuses on spiritual well-being, sleep, mood, and overall…

This study looks at whether advanced MRI scans can better predict how patients with newly diagnosed glioblastoma respond to Optune therapy compared to standard MRI. About 60 participants will be followed for up to a year to see who is still alive. The goal is to improve how docto…

This study looks at whether simple blood tests can help doctors understand how glioblastoma, a serious brain cancer, changes over time. About 100 newly diagnosed patients will give blood samples before and after standard radiation and chemotherapy. The goal is to see if DNA from …

This study looks at how immune cells (T cells) in the blood and bone marrow change over time in people with glioblastoma, a serious brain cancer. Researchers want to gather basic information to help design new types of immunotherapy. About 40 adults with newly diagnosed glioblast…

This study tests whether doing extra MRI scans each week during radiation treatment can help doctors adjust the radiation plan to better target high-grade gliomas, an aggressive type of brain cancer. About 20 adults with newly diagnosed glioblastoma or similar tumors will receive…

This early-phase trial studies how two oral drugs, defactinib and VS-6766, enter glioblastoma tumors and the surrounding brain tissue. Fourteen adults with new or recurrent glioblastoma who need surgery will take a single dose of one drug before their tumor is removed. The main g…

This study is observing 1,000 adults with recurrent malignant gliomas (aggressive brain tumors) to see how they respond to chemotherapy and targeted therapy. Researchers will track survival and tumor progression over time. The goal is to gather real-world data to help doctors cho…

This study explores whether having patients report symptoms through an app and complete cognitive tests can help doctors schedule MRI scans at the right time, instead of using a fixed schedule. It involves 20 adults with newly diagnosed glioblastoma who are undergoing standard tr…

This study collects multiple samples from glioblastoma tumors during surgery to help researchers understand how genetic changes differ across the tumor. The goal is to learn more about the disease, which may lead to better diagnosis and treatments in the future. About 18 adults w…

This study explores whether an Apple Watch can track changes in walking, heart rate, breathing, and sleep in people with glioblastoma. The goal is to see if these measurements can help predict symptoms or complications before they happen. About 25 adults with newly diagnosed or r…

This study looks at how doctors share information about brain tumors, scan results, and treatment choices with patients and their caregivers. Researchers hope to learn what helps or hinders clear communication about prognosis and care goals. About 309 people with glioblastoma, th…

This study tests a new ultrasound system (SonoClear®) that uses a special gel to mimic brain tissue, aiming to give surgeons clearer images during brain tumor removal. Fifteen adults with glioma (a type of brain tumor) are participating. The main goal is to see if the new system …