Brain cancer vaccine trial combines custom peptides with electric fields
NCT ID NCT03223103
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This early-phase trial tests whether a personalized vaccine made from each patient's tumor mutations, combined with Tumor Treating Fields (a device that sends electric fields to the brain), is safe and feasible for people with newly diagnosed glioblastoma. The 13 participants receive the vaccine alongside standard care. The main goals are to check for side effects and see if the vaccine can be successfully made and given.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- personalized mutation-derived tumor vaccine (peptides) plus Poly-ICLC (Hiltonol) and Tumor Treating Fields (Optune device)
- What this could lead to
- If successful, this could point toward a new way to treat glioblastoma by combining a personalized vaccine with standard care to help the immune system target the tumor.
- What could go wrong
- This is a very early (Phase 1) and small (13 people) trial focused on safety, not effectiveness. The vaccine is custom-made for each patient, which is complex and may not work for everyone. There is also a risk of side effects from the vaccine or device.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Albert Einstein College of Medicine
The Bronx, New York, 10461, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a One-Two punch slow recurrent brain cancer?