New personalized Vaccine-Like therapy takes on deadly brain cancer

NCT ID NCT04485949

Ongoing Disease control Sponsor: Imvax Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2b trial tests IGV-001, a personalized immunotherapy made from each patient's own tumor cells, for newly diagnosed glioblastoma. About 93 participants receive either IGV-001 or a placebo, along with standard radiation and chemotherapy. The goal is to see if the treatment can delay tumor growth and improve survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

IGV-001 (personalized cell immunotherapy using the patient's own tumor cells combined with an antisense oligonucleotide)

What this could lead to

If successful, this could offer a new treatment option that slows glioblastoma progression and extends survival for newly diagnosed patients.

What could go wrong

This is a mid-stage trial with only 93 participants, so results may not apply to all patients. The treatment is complex and personalized, and side effects are still being studied.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA

Contacts and locations

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Locations

Columbia University Medical Center

New York, New York, 10032, United States
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center

New York, New York, 10021, United States
Henry Ford Health System

Detroit, Michigan, 48202, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Jersey Shore University Medical Center

Neptune City, New Jersey, 07753, United States
John Theurer Cancer Center At Hackensack UMC

Hackensack, New Jersey, 07601, United States
Lenox Hill Hospital

New York, New York, 10075, United States
Mayo Clinic - Jacksonville

Jacksonville, Florida, 32224, United States
Montefiore Medical Center

The Bronx, New York, 10467, United States
Northwell Health at North Shore University Hospital

Manhasset, New York, 11030, United States
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
The Ohio State University (OSU) Wexner Medical Center

Columbus, Ohio, 43201, United States
The Pennsylvania State University (Penn State) Milton S. Hershey Medical Center

Hershey, Pennsylvania, 17033, United States
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
UC Health

Cincinnati, Ohio, 45229, United States
University of North Carolina (UNC) - Chapel Hill

Chapel Hill, North Carolina, 27599, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19130, United States
University of Wisconsin - Madison

Madison, Wisconsin, 53705, United States
Weill Cornell Medicine

New York, New York, 10065, United States
West Virginia University

Morgantown, West Virginia, 26506, United States
Westchester Medical Center

Valhalla, New York, 10595, United States