Experimental brain cancer treatment combines DNA vaccine with immune therapy
NCT ID NCT03491683
Summary
This trial is testing whether combining a DNA vaccine (INO-5401 and INO-9012) with an immune checkpoint inhibitor drug (cemiplimab) can help fight newly-diagnosed glioblastoma, an aggressive brain cancer. The treatment is given alongside standard radiation and chemotherapy to 52 patients. Researchers are checking if this combination is safe, stimulates the immune system, and might help patients live longer.
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Contacts and locations
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Locations
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Baylor College of Medicine
Houston, Texas, 77030, United States
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City of Hope
Duarte, California, 91010, United States
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Columbia University Medical Center The Neurological Institute of New York
New York, New York, 10032, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Emory University School of Medicine
Atlanta, Georgia, 30322, United States
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Henry Ford Health System
Detroit, Michigan, 48202, United States
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Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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New York University Langone Medical Center; Perlmutter Cancer Center
New York, New York, 10016, United States
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New York-Presbyterian Hospital/Weill Cornell Medical Center
New York, New York, 10065, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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Rutgers University - Cancer Institute of New Jersey
New Brunswick, New Jersey, 08901, United States
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Stanford University, School of Medicine
Palo Alto, California, 94304, United States
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Stephenson Cancer Center
Oklahoma City, Oklahoma, 73104, United States
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Texas Oncology
Austin, Texas, 78705, United States
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UPMC Cancer Center Neuro-Oncology; UPMC Cancer Pavilion
Pittsburgh, Pennsylvania, 15232, United States
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University of California, San Francisco
San Francisco, California, 94143, United States
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University of Miami - Sylvester Comprehensive Cancer Center
Miami, Florida, 33136, United States
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University of North Carolina School of Medicine
Chapel Hill, North Carolina, 27599, United States
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University of Pennsylvania Health System: Penn Medicine
Philadelphia, Pennsylvania, 19104, United States
Conditions
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