Experimental virus therapy for brain cancer trial pulled before it began
NCT ID NCT04105374
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study planned to test a two-part experimental treatment for newly diagnosed glioblastoma, a fast-growing brain cancer. The treatment combined a modified virus (Toca 511) designed to enter tumor cells and an extended-release antifungal drug (Toca FC) that the virus helps turn into a cancer-killing agent. This was to be added to standard therapy (chemotherapy and radiation). However, the trial was withdrawn before any patients were enrolled, so no data were collected.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Toca 511 (a modified virus) and Toca FC (an extended-release antifungal drug)
- What this could lead to
- If it had worked, this approach could have helped shrink or stabilize glioblastoma tumors and possibly extend patients' lives.
- What could go wrong
- The trial was withdrawn before enrolling any participants, so no results are available. Early-phase studies of similar approaches have shown mixed outcomes, and the treatment carries risks from the virus and chemotherapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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