Nrg Oncology

This study is for people with inoperable, locally advanced non-small cell lung cancer. It compares the current standard treatment (chemotherapy plus standard radiation, followed by a year of immunotherapy or targeted pills) against a new approach that adds a short, intense burst …

This study is testing a new approach to decide on chemotherapy after colon cancer surgery. It uses a blood test that looks for tiny bits of leftover cancer DNA. The goal is to give strong chemo only to patients who really need it based on their test results, and possibly avoid it…

This study is testing whether adding a precise, high-dose radiation treatment (SBRT) to standard immunotherapy drugs helps people with advanced liver cancer live longer. About 252 participants with liver cancer that has spread into major blood vessels will receive either immunoth…

This study aims to find out if proton beam radiation therapy works better and causes fewer serious heart and lung side effects than the standard photon radiation therapy for people with esophageal cancer. About 300 patients with stage I-IVA esophageal cancer will be randomly assi…

This large Phase 3 trial is testing whether a much shorter, more intense course of radiation (5 sessions) works as well as the standard longer course (20 sessions) for patients with muscle-invasive bladder cancer. All participants will also receive standard chemotherapy. The main…

This study aims to determine whether adding radiation therapy after complete surgical removal of a specific type of brain tumor (grade 2 meningioma) helps prevent the tumor from coming back. About 163 adults who have had successful surgery will be randomly assigned to either rece…

This study is testing if giving radiation therapy to high-risk, painless bone metastases can prevent serious bone complications like fractures or spinal cord compression. It will compare adding radiation to the usual care (like bone-strengthening drugs) in 280 cancer patients who…

This study aims to find the best radiation method for treating cancer that has spread to the brain. It compares giving one large radiation dose versus spreading the same total radiation over three smaller treatments. Researchers want to see which approach better controls the brai…

This study is comparing two different surgical approaches for patients with early-stage oral cavity cancer that hasn't spread to the lymph nodes. It aims to see if a less invasive procedure, called a sentinel lymph node biopsy, is as effective as the standard, more extensive neck…

This study is for people with advanced kidney cancer that has spread and is not recommended for surgery. It tests whether adding a short, highly focused course of radiation to the main kidney tumor, while patients receive standard immunotherapy drugs, helps control the cancer bet…

This study is for men whose prostate cancer has spread to nearby lymph nodes after surgery. It tests if adding a drug called apalutamide to the usual hormone and radiation therapy can better control the cancer and prevent it from spreading further. The goal is to see if this stro…

This large study aims to find out if adding chemotherapy is better than not using it for young, premenopausal women with early-stage, hormone-sensitive breast cancer that has a low-to-intermediate risk of returning. All participants will receive standard hormone-blocking treatmen…

This study compares two radiation treatments for patients whose small cell lung cancer has spread to the brain. One method targets only the tumors with high precision, while the other treats the whole brain but avoids the memory center. The main goal is to see which approach bett…

This large trial aims to see if one year of maintenance therapy is just as effective as two years for patients with advanced ovarian cancer who have specific genetic changes and responded well to initial chemotherapy. It will test two drugs, olaparib and bevacizumab, which work t…

This large study is testing whether some women with early-stage, low-risk breast cancer can safely skip radiation therapy after breast-conserving surgery. It will compare the standard treatment of surgery plus radiation and hormone pills to a simpler approach of just surgery and …

This study is testing new targeted drug treatments for advanced salivary gland cancer that has returned, spread, or cannot be removed by surgery. It compares two newer drug combinations against a standard chemotherapy treatment to see which is better at controlling the cancer and…

This study is testing whether delivering a higher, more focused dose of radiation can help people with advanced pancreatic cancer live longer. It's for patients whose cancer hasn't spread widely and who have already had 4-6 months of chemotherapy. Participants are randomly assign…

This study is for men whose prostate cancer has spread to a limited number of other body sites but still responds to hormone therapy. It compares standard radiation treatment alone to radiation combined with a daily pill (relugolix) that lowers testosterone. The goal is to see if…

This study is for people with breast or non-small cell lung cancer that has spread to the fluid-filled space around the brain and spinal cord. It compares two types of radiation therapy to see which one helps patients live longer. One method targets only the specific areas causin…

This large trial is testing if a gene test (Decipher) can help personalize treatment for men with intermediate-risk prostate cancer. Men with a low-risk gene score will be randomly assigned to receive either radiation alone or the standard combination of radiation plus hormone th…

This study compares two ways of checking lymph nodes during hysterectomy for early-stage endometrial cancer. One method removes many lymph nodes (standard care), while the other uses a dye to find and remove only key 'sentinel' nodes. The main goal is to see if the sentinel node …

This large trial is comparing two different radiation schedules for men with high-risk prostate cancer. It will test if a much shorter, more intense treatment (5 sessions over 2 weeks) is as effective at preventing the cancer from spreading as the standard, longer course (20-45 s…

This study is comparing two surgical options to prevent ovarian cancer in women who carry a BRCA1 gene mutation. One surgery removes only the fallopian tubes, while the standard surgery removes both the tubes and ovaries. The goal is to see if the less invasive option is nearly a…

This study is testing whether a special computer-based brain training program can help breast cancer survivors who are struggling with memory and thinking problems, often called 'chemo brain.' Researchers will compare the brain training to a simpler computer activity in nearly 40…

This study is testing phone-based support programs to help people manage the side effects and emotional distress that often come with taking oral cancer medications at home. Researchers are comparing two approaches: one involves weekly check-in calls that report symptoms to docto…

This study is testing two different ways to deliver mindfulness training to help younger breast cancer survivors who are feeling depressed or fatigued after finishing their main cancer treatments. It will compare a live, instructor-led class over Zoom with a self-paced smartphone…

This study is testing if adding an investigational drug called BMX-001 to standard symptom care can better prevent severe mouth sores in people receiving combined chemotherapy and radiation for head and neck cancer. About 98 participants will be randomly assigned to receive eithe…

This study aims to find the best schedule for follow-up colonoscopies in people who have had 1-2 small, low-risk polyps removed. It will compare whether getting a follow-up colonoscopy every 10 years is just as effective at preventing colorectal cancer as getting one every 5 year…

This study aims to find a more accurate way to calculate the right dose of the chemotherapy drug carboplatin for cancer patients. Researchers will test if a special dye (iohexol) can help measure kidney function better than standard blood tests, which is key for safe dosing. The …