New hope for advanced liver cancer: radiation boosts immunotherapy in major trial
NCT ID NCT07166406
First seen Jun 26, 2026 · Last updated Aug 18, 2026 · Updated 2 times
Summary
This phase 3 trial is for people with advanced liver cancer that has spread to nearby blood vessels. It compares standard immunotherapy drugs (atezolizumab and bevacizumab) alone versus the same drugs plus targeted radiation (SBRT). The goal is to see if adding radiation helps patients live longer. About 226 participants will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Atezolizumab and bevacizumab (immunotherapy drugs)
- What this could lead to
- If it works, this could show that adding targeted radiation to standard immunotherapy helps people with advanced liver cancer live longer.
- What could go wrong
- This is a phase 3 trial, but it is still experimental. Adding radiation may increase side effects without improving survival. Results are not guaranteed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 226 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2026
- Expected to finish
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Mar 2034
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * PRIOR TO STEP 1 REGISTRATION: * Diagnosis of hepatocellular carcinoma (HCC) by at least 1 criterion listed below: * Pathologically (histologically or cytologically) proven diagnosis of HCC (strongly recommended) * Radiographically proven (American Association for the Study of Liver Diseases \[AASLD\] criteria) diagnosis of HCC by multiphasic MRI and/or CT scan is allowed. * For patients with a prior or concurrent malignancy, pathologic confirmation of hepatocellular cancer is required. * HCC macrovascular invasion, defined as enhancing vascular thrombosis demonstrating arterial enhancement and venous or delayed venous washout on multiphasic MRI and/or CT is required. * Presence of extrahepatic metastatic disease on CT chest and CT or MRI pelvis, or PET/CT chest/abdomen/pelvis is permitted. * 5 or fewer discrete intrahepatic parenchymal foci of HCC. * Total maximal sum of hepatocellular carcinoma tumors, as a single conglomerate, multiple lesions, or infiltrative HCC \< 20 cm in total summed diameter. * No direct primary tumor extension into the stomach, duodenum, small bowel, or large bowel. * No known fibrolamellar HCC, sarcomatoid HCC, or biphenotypic HCC. * Child-Pugh class A or B7 liver function. * Age ≥ 18. * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2. * Not pregnant and not nursing * Negative urine or serum pregnancy test (in persons of childbearing potential) within 30 days prior to registration. Childbearing potential is defined as any person who has experienced menarche and who has not undergone surgical sterilization (hysterectomy or bilateral oophorectomy) or who is not postmenopausal. * Absolute neutrophil count (ANC) ≥ 1,500 cells/mm\^3. * Platelets ≥ 60,000 cells/mm\^3. * Hemoglobin ≥ 8g/dl (Note: The use of transfusion or other intervention to achieve hemoglobin \[Hgb\] ≥ 8g/dl is acceptable). * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 6 x institutional upper limit of normal (ULN). * Total bilirubin \< 4 x institutional ULN. * Creatinine clearance (CrCL) ≥ 30 mL/min/1.73 m\^2 by the Cockcroft-Gault formula. * For treatment of HCC: * Prior surgical resection, transarterial chemoembolization (TACE), and ablation are permitted. * No prior systemic therapy or transarterial radioembolization (TARE) for HCC. * No history of liver transplantation. * For prior treatment for any malignancy: * Prior systemic therapy for a different cancer is allowable, except for prior immunotherapy. * No prior radiotherapy to the region of the study cancer that would result in significant overlap of radiation therapy fields that would lead to excessive cumulative toxicity at the discretion of the investigator. * No medical contraindication to the standard of care immunotherapy. * For patients to be treated with atezolizumab/bevacizumab: * No history of a gastrointestinal (GI) bleed or other clinically significant bleeding event within 6 months prior to study registration. * Systemic immunostimulatory agents (including, but not limited to, interferons and interleukin-2 \[IL-2\]) are prohibited within 4 weeks or five drug elimination half-lives (whichever is longer) prior to registration and during the study period. * No history of allergic reaction to the systemic therapy agent(s), compounds of similar chemical or biologic composition to the systemic therapy agent(s) (or any of its excipients). * PRIOR TO STEP 2 RANDOMIZATION: * Obtain confirmation of payment coverage (insurance or other) for both possible treatment arms.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
139 sites in 2 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
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Locations
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Allegiance Health
RECRUITINGJackson, Michigan, 49201, United States
Contact Email: •••••@•••••
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Alta Bates Summit Medical Center-Herrick Campus
RECRUITINGBerkeley, California, 94704, United States
Contact Email: •••••@•••••
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California Pacific Medical Center-Pacific Campus
RECRUITINGSan Francisco, California, 94115, United States
Contact Email: •••••@•••••
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Cancer Care and Hematology-Fort Collins
RECRUITINGFort Collins, Colorado, 80528, United States
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Carle Cancer Center
RECRUITINGUrbana, Illinois, 61801, United States
Contact Email: •••••@•••••
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Carle Physician Group-Effingham
RECRUITINGEffingham, Illinois, 62401, United States
Contact Email: •••••@•••••
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Carle Physician Group-Mattoon/Charleston
RECRUITINGMattoon, Illinois, 61938, United States
Contact Email: •••••@•••••
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Carle at The Riverfront
RECRUITINGDanville, Illinois, 61832, United States
Contact Email: •••••@•••••
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Case Western Reserve University
RECRUITINGCleveland, Ohio, 44106, United States
Contact Email: •••••@•••••
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Christiana Care Health System-Christiana Hospital
RECRUITINGNewark, Delaware, 19718, United States
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Christiana Care Health System-Concord Health Center
RECRUITINGChadds Ford, Pennsylvania, 19317, United States
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Christiana Care Health System-Wilmington Hospital
RECRUITINGWilmington, Delaware, 19801, United States
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Clackamas Radiation Oncology Center
RECRUITINGClackamas, Oregon, 97015, United States
Contact Email: •••••@•••••
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Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
RECRUITINGLebanon, New Hampshire, 03756, United States
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Drexel Town Square Health Center
RECRUITINGOak Creek, Wisconsin, 53154, United States
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Duke Cancer Center Raleigh
RECRUITINGRaleigh, North Carolina, 27609, United States
Contact Email: •••••@•••••
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
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Duluth Clinic Ashland
RECRUITINGAshland, Wisconsin, 54806, United States
Contact Email: •••••@•••••
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Emory Proton Therapy Center
RECRUITINGAtlanta, Georgia, 30308, United States
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Emory Saint Joseph's Hospital
RECRUITINGAtlanta, Georgia, 30342, United States
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Emory University Hospital Midtown
RECRUITINGAtlanta, Georgia, 30308, United States
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Emory University Hospital/Winship Cancer Institute
RECRUITINGAtlanta, Georgia, 30322, United States
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Essentia Health - Deer River Clinic
RECRUITINGDeer River, Minnesota, 56636, United States
Contact Email: •••••@•••••
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Essentia Health Cancer Center
RECRUITINGDuluth, Minnesota, 55805, United States
Contact Email: •••••@•••••
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Essentia Health Hibbing Clinic
RECRUITINGHibbing, Minnesota, 55746, United States
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Essentia Health Saint Joseph's Medical Center
RECRUITINGBrainerd, Minnesota, 56401, United States
Contact Email: •••••@•••••
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Essentia Health Saint Mary's Hospital - Superior
RECRUITINGSuperior, Wisconsin, 54880, United States
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Essentia Health Saint Mary's Medical Center
RECRUITINGDuluth, Minnesota, 55805, United States
Contact Email: •••••@•••••
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Essentia Health Sandstone
RECRUITINGSandstone, Minnesota, 55072, United States
Contact Email: •••••@•••••
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Essentia Health Virginia Clinic
RECRUITINGVirginia, Minnesota, 55792, United States
Contact Email: •••••@•••••
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Essentia Health-Hayward Clinic
RECRUITINGHayward, Wisconsin, 54843, United States
Contact Email: •••••@•••••
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Essentia Health-Spooner Clinic
RECRUITINGSpooner, Wisconsin, 54801, United States
Contact Email: •••••@•••••
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Froedtert Menomonee Falls Hospital
RECRUITINGMenomonee Falls, Wisconsin, 53051, United States
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Froedtert West Bend Hospital/Kraemer Cancer Center
RECRUITINGWest Bend, Wisconsin, 53095, United States
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Froedtert and MCW Moorland Reserve Health Center
RECRUITINGNew Berlin, Wisconsin, 53151, United States
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Geisinger Cancer Center Dickson City
RECRUITINGDickson City, Pennsylvania, 18519, United States
Contact Email: •••••@•••••
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Geisinger Medical Center
RECRUITINGDanville, Pennsylvania, 17822, United States
Contact Email: •••••@•••••
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Geisinger Medical Oncology-Lewisburg
RECRUITINGLewisburg, Pennsylvania, 17837, United States
Contact Email: •••••@•••••
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Geisinger Wyoming Valley/Henry Cancer Center
RECRUITINGWilkes-Barre, Pennsylvania, 18711, United States
Contact Email: •••••@•••••
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Grady Health System
RECRUITINGAtlanta, Georgia, 30303, United States
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Greater Regional Medical Center
RECRUITINGCreston, Iowa, 50801, United States
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Helen F Graham Cancer Center
RECRUITINGNewark, Delaware, 19713, United States
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Henry Ford Cancer Institute-Downriver
RECRUITINGBrownstown, Michigan, 48183, United States
Contact Email: •••••@•••••
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Henry Ford Hospital
RECRUITINGDetroit, Michigan, 48202, United States
Contact Email: •••••@•••••
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Henry Ford Medical Center-Columbus
RECRUITINGNovi, Michigan, 48377, United States
Contact Email: •••••@•••••
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Henry Ford Medical Center-Fairlane
RECRUITINGDearborn, Michigan, 48126, United States
Contact Email: •••••@•••••
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Henry Ford West Bloomfield Hospital
RECRUITINGWest Bloomfield, Michigan, 48322, United States
Contact Email: •••••@•••••
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Henry Ford Wyandotte Hospital
RECRUITINGWyandotte, Michigan, 48192, United States
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Inova Alexandria Hospital
RECRUITINGAlexandria, Virginia, 22304, United States
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Inova Fair Oaks Hospital
RECRUITINGFairfax, Virginia, 22033, United States
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Inova Fairfax Hospital
RECRUITINGFalls Church, Virginia, 22042, United States
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Inova Loudoun Hospital
RECRUITINGLeesburg, Virginia, 20176, United States
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Inova Schar Cancer Institute
RECRUITINGFairfax, Virginia, 22031, United States
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Iowa Methodist Medical Center
RECRUITINGDes Moines, Iowa, 50309, United States
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Marshfield Medical Center - Weston
RECRUITINGWeston, Wisconsin, 54476, United States
Contact Email: •••••@•••••
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Marshfield Medical Center-EC Cancer Center
RECRUITINGEau Claire, Wisconsin, 54701, United States
Contact Email: •••••@•••••
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Marshfield Medical Center-Marshfield
RECRUITINGMarshfield, Wisconsin, 54449, United States
Contact Email: •••••@•••••
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Marshfield Medical Center-Rice Lake
RECRUITINGRice Lake, Wisconsin, 54868, United States
Contact Email: •••••@•••••
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Marshfield Medical Center-River Region at Stevens Point
RECRUITINGStevens Point, Wisconsin, 54482, United States
Contact Email: •••••@•••••
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Massachusetts General Hospital Cancer Center
RECRUITINGBoston, Massachusetts, 02114, United States
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Medical Center of the Rockies
RECRUITINGLoveland, Colorado, 80538, United States
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Medical Oncology Hematology Consultants PA
RECRUITINGNewark, Delaware, 19713, United States
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Memorial Hospital East
RECRUITINGShiloh, Illinois, 62269, United States
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Memorial Hospital North
RECRUITINGColorado Springs, Colorado, 80920, United States
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Mercy Cancer Center-West Lakes
RECRUITINGClive, Iowa, 50325, United States
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Mercy Medical Center - Des Moines
RECRUITINGDes Moines, Iowa, 50314, United States
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Mercy Medical Center-West Lakes
RECRUITINGWest Des Moines, Iowa, 50266, United States
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Miller-Dwan Hospital
RECRUITINGDuluth, Minnesota, 55805, United States
Contact Email: •••••@•••••
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Montefiore Medical Center - Moses Campus
RECRUITINGThe Bronx, New York, 10467, United States
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Montefiore Medical Center-Einstein Campus
RECRUITINGThe Bronx, New York, 10461, United States
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Mount Sinai Hospital
RECRUITINGNew York, New York, 10029, United States
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Nebraska Medicine-Bellevue
RECRUITINGBellevue, Nebraska, 68123, United States
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Nebraska Medicine-Village Pointe
RECRUITINGOmaha, Nebraska, 68118, United States
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Northwell Health/Center for Advanced Medicine
RECRUITINGLake Success, New York, 11042, United States
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Northwest Wisconsin Cancer Center
RECRUITINGAshland, Wisconsin, 54806, United States
Contact Email: •••••@•••••
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
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Palo Alto Medical Foundation Health Care
RECRUITINGPalo Alto, California, 94301, United States
Contact Email: •••••@•••••
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Palo Alto Medical Foundation-Camino Division
RECRUITINGMountain View, California, 94040, United States
Contact Email: •••••@•••••
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Palo Alto Medical Foundation-Fremont
RECRUITINGFremont, California, 94538, United States
Contact Email: •••••@•••••
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Palo Alto Medical Foundation-Sunnyvale
RECRUITINGSunnyvale, California, 94086, United States
Contact Email: •••••@•••••
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Poudre Valley Hospital
RECRUITINGFort Collins, Colorado, 80524, United States
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ProHealth D N Greenwald Center
RECRUITINGMukwonago, Wisconsin, 53149, United States
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ProHealth Oconomowoc Memorial Hospital
RECRUITINGOconomowoc, Wisconsin, 53066, United States
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Providence Newberg Medical Center
RECRUITINGNewberg, Oregon, 97132, United States
Contact Email: •••••@•••••
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Providence Portland Medical Center
RECRUITINGPortland, Oregon, 97213, United States
Contact Email: •••••@•••••
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Providence Saint Vincent Medical Center
RECRUITINGPortland, Oregon, 97225, United States
Contact Email: •••••@•••••
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Providence Willamette Falls Medical Center
RECRUITINGOregon City, Oregon, 97045, United States
Contact Email: •••••@•••••
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Rocky Mountain Cancer Centers-Penrose
RECRUITINGColorado Springs, Colorado, 80907, United States
Contact Email: •••••@•••••
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Saint Mary's Hospital and Regional Medical Center
RECRUITINGGrand Junction, Colorado, 81501, United States
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Siteman Cancer Center at Christian Hospital
RECRUITINGSt Louis, Missouri, 63136, United States
Contact Email: •••••@•••••
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Siteman Cancer Center at Saint Peters Hospital
RECRUITINGCity of Saint Peters, Missouri, 63376, United States
Contact Email: •••••@•••••
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Siteman Cancer Center at West County Hospital
RECRUITINGCreve Coeur, Missouri, 63141, United States
Contact Email: •••••@•••••
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Siteman Cancer Center-South County
RECRUITINGSt Louis, Missouri, 63129, United States
Contact Email: •••••@•••••
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Smilow Cancer Center/Yale-New Haven Hospital
RECRUITINGNew Haven, Connecticut, 06510, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital Care Center - Guilford
RECRUITINGGuilford, Connecticut, 06437, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital Care Center - Waterford
RECRUITINGWaterford, Connecticut, 06385, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital Care Center at Glastonbury
RECRUITINGGlastonbury, Connecticut, 06033, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital Care Center at Greenwich
RECRUITINGGreenwich, Connecticut, 06830, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital Care Center at Long Ridge
RECRUITINGStamford, Connecticut, 06902, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital Care Center at Saint Francis
RECRUITINGHartford, Connecticut, 06105, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital Care Center-Fairfield
RECRUITINGFairfield, Connecticut, 06824, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital Care Center-Trumbull
RECRUITINGTrumbull, Connecticut, 06611, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital-Derby Care Center
RECRUITINGDerby, Connecticut, 06418, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital-Hamden Care Center
RECRUITINGHamden, Connecticut, 06518, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital-Torrington Care Center
RECRUITINGTorrington, Connecticut, 06790, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital-Waterbury Care Center
RECRUITINGWaterbury, Connecticut, 06708, United States
Contact Email: •••••@•••••
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Sutter Cancer Centers Radiation Oncology Services-Cameron Park
RECRUITINGCameron Park, California, 95682, United States
Contact Email: •••••@•••••
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Sutter Cancer Centers Radiation Oncology Services-Roseville
RECRUITINGRoseville, California, 95661, United States
Contact Email: •••••@•••••
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Sutter Medical Center Sacramento
RECRUITINGSacramento, California, 95816, United States
Contact Email: •••••@•••••
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Sutter Pacific Medical Foundation
RECRUITINGSanta Rosa, California, 95403, United States
Contact Email: •••••@•••••
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Sutter Roseville Medical Center
RECRUITINGRoseville, California, 95661, United States
Contact Email: •••••@•••••
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The Iowa Clinic PC
RECRUITINGWest Des Moines, Iowa, 50266, United States
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UC Comprehensive Cancer Center at Silver Cross
RECRUITINGNew Lenox, Illinois, 60451, United States
Contact Email: •••••@•••••
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UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITINGOrange, California, 92868, United States
Contact Email: •••••@•••••
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UCHealth Greeley Hospital
RECRUITINGGreeley, Colorado, 80631, United States
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UCHealth Memorial Hospital Central
RECRUITINGColorado Springs, Colorado, 80909, United States
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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITINGIrvine, California, 92612, United States
Contact Email: •••••@•••••
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UChicago Medicine Northwest Indiana
RECRUITINGCrown Point, Indiana, 46307, United States
Contact Email: •••••@•••••
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UH Seidman Cancer Center at Lake Health Mentor Campus
RECRUITINGMentor, Ohio, 44060, United States
Contact Email: •••••@•••••
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UH Seidman Cancer Center at UH Avon Health Center
RECRUITINGAvon, Ohio, 44011, United States
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UHHS-Chagrin Highlands Medical Center
RECRUITINGBeachwood, Ohio, 44122, United States
Contact Email: •••••@•••••
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UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITINGAnkeny, Iowa, 50023, United States
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UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITINGDes Moines, Iowa, 50309, United States
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UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITINGDes Moines, Iowa, 50314, United States
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UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITINGWaukee, Iowa, 50263, United States
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UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITINGClive, Iowa, 50325, United States
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UW Cancer Center at ProHealth Care
RECRUITINGWaukesha, Wisconsin, 53188, United States
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University Health Network-Princess Margaret Hospital
RECRUITINGToronto, Ontario, M5G 2M9, Canada
Contact Email: •••••@•••••
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University of California Davis Comprehensive Cancer Center
RECRUITINGSacramento, California, 95817, United States
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University of Chicago Comprehensive Cancer Center
RECRUITINGChicago, Illinois, 60637, United States
Contact Email: •••••@•••••
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University of Chicago Medicine-Orland Park
RECRUITINGOrland Park, Illinois, 60462, United States
Contact Email: •••••@•••••
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University of Illinois
RECRUITINGChicago, Illinois, 60612, United States
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University of Kentucky/Markey Cancer Center
RECRUITINGLexington, Kentucky, 40536, United States
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University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68198, United States
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University of New Mexico Cancer Center
RECRUITINGAlbuquerque, New Mexico, 87106, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Email: •••••@•••••
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Yale University
RECRUITINGNew Haven, Connecticut, 06520, United States
Contact Email: •••••@•••••
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Yale-New Haven Hospital North Haven Medical Center
RECRUITINGNorth Haven, Connecticut, 06473, United States
Contact Email: •••••@•••••
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