New hope for advanced liver cancer: radiation boosts immunotherapy in major trial

NCT ID NCT07166406

Recruiting now Disease control Sponsor: NRG Oncology Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 3 trial is for people with advanced liver cancer that has spread to nearby blood vessels. It compares standard immunotherapy drugs (atezolizumab and bevacizumab) alone versus the same drugs plus targeted radiation (SBRT). The goal is to see if adding radiation helps patients live longer. About 226 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Atezolizumab and bevacizumab (immunotherapy drugs)
What this could lead to: If it works, this could show that adding targeted radiation to standard immunotherapy helps people with advanced liver cancer live longer.
What could go wrong: This is a phase 3 trial, but it is still experimental. Adding radiation may increase side effects without improving survival. Results are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED HEPATOCELLULAR CARCINOMA STAGE III HEPATOCELLULAR CARCINOMA AJCC V8 STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8

Contacts and locations

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Allegiance Health
RECRUITING

Jackson, Michigan, 49201, United States

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Alta Bates Summit Medical Center-Herrick Campus
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Berkeley, California, 94704, United States

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California Pacific Medical Center-Pacific Campus
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San Francisco, California, 94115, United States

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Cancer Care and Hematology-Fort Collins
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Fort Collins, Colorado, 80528, United States

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Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

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Carle Physician Group-Effingham
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Effingham, Illinois, 62401, United States

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Carle Physician Group-Mattoon/Charleston
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Mattoon, Illinois, 61938, United States

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Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

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Case Western Reserve University
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Cleveland, Ohio, 44106, United States

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Christiana Care Health System-Christiana Hospital
RECRUITING

Newark, Delaware, 19718, United States

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Christiana Care Health System-Concord Health Center
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Chadds Ford, Pennsylvania, 19317, United States

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Christiana Care Health System-Wilmington Hospital
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Wilmington, Delaware, 19801, United States

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Clackamas Radiation Oncology Center
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Clackamas, Oregon, 97015, United States

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Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
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Lebanon, New Hampshire, 03756, United States

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Drexel Town Square Health Center
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Oak Creek, Wisconsin, 53154, United States

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Duke Cancer Center Raleigh
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Raleigh, North Carolina, 27609, United States

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Duke University Medical Center
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Durham, North Carolina, 27710, United States

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Duluth Clinic Ashland
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Ashland, Wisconsin, 54806, United States

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Emory Proton Therapy Center
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Atlanta, Georgia, 30308, United States

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Emory Saint Joseph's Hospital
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Atlanta, Georgia, 30342, United States

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Emory University Hospital Midtown
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Atlanta, Georgia, 30308, United States

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Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, 30322, United States

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Essentia Health - Deer River Clinic
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Deer River, Minnesota, 56636, United States

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Essentia Health Cancer Center
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Duluth, Minnesota, 55805, United States

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Essentia Health Hibbing Clinic
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Hibbing, Minnesota, 55746, United States

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Essentia Health Saint Joseph's Medical Center
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Brainerd, Minnesota, 56401, United States

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Essentia Health Saint Mary's Hospital - Superior
RECRUITING

Superior, Wisconsin, 54880, United States

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Essentia Health Saint Mary's Medical Center
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Duluth, Minnesota, 55805, United States

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Essentia Health Sandstone
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Sandstone, Minnesota, 55072, United States

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Essentia Health Virginia Clinic
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Virginia, Minnesota, 55792, United States

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Essentia Health-Hayward Clinic
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Hayward, Wisconsin, 54843, United States

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Essentia Health-Spooner Clinic
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Spooner, Wisconsin, 54801, United States

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Froedtert Menomonee Falls Hospital
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Menomonee Falls, Wisconsin, 53051, United States

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Froedtert West Bend Hospital/Kraemer Cancer Center
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West Bend, Wisconsin, 53095, United States

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Froedtert and MCW Moorland Reserve Health Center
RECRUITING

New Berlin, Wisconsin, 53151, United States

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Geisinger Cancer Center Dickson City
RECRUITING

Dickson City, Pennsylvania, 18519, United States

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Geisinger Medical Center
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Danville, Pennsylvania, 17822, United States

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Geisinger Medical Oncology-Lewisburg
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Lewisburg, Pennsylvania, 17837, United States

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Geisinger Wyoming Valley/Henry Cancer Center
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States

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Grady Health System
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Atlanta, Georgia, 30303, United States

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Greater Regional Medical Center
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Creston, Iowa, 50801, United States

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Helen F Graham Cancer Center
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Newark, Delaware, 19713, United States

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Henry Ford Cancer Institute-Downriver
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Brownstown, Michigan, 48183, United States

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Henry Ford Hospital
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Detroit, Michigan, 48202, United States

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Henry Ford Medical Center-Columbus
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Novi, Michigan, 48377, United States

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Henry Ford Medical Center-Fairlane
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Dearborn, Michigan, 48126, United States

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Henry Ford West Bloomfield Hospital
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West Bloomfield, Michigan, 48322, United States

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Henry Ford Wyandotte Hospital
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Wyandotte, Michigan, 48192, United States

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Inova Alexandria Hospital
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Alexandria, Virginia, 22304, United States

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Inova Fair Oaks Hospital
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Fairfax, Virginia, 22033, United States

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Inova Fairfax Hospital
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Falls Church, Virginia, 22042, United States

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Inova Loudoun Hospital
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Leesburg, Virginia, 20176, United States

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Inova Schar Cancer Institute
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Fairfax, Virginia, 22031, United States

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Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States

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Marshfield Medical Center - Weston
RECRUITING

Weston, Wisconsin, 54476, United States

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Marshfield Medical Center-EC Cancer Center
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Eau Claire, Wisconsin, 54701, United States

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Marshfield Medical Center-Marshfield
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Marshfield, Wisconsin, 54449, United States

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Marshfield Medical Center-Rice Lake
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Rice Lake, Wisconsin, 54868, United States

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Marshfield Medical Center-River Region at Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54482, United States

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Massachusetts General Hospital Cancer Center
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Boston, Massachusetts, 02114, United States

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Medical Center of the Rockies
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Loveland, Colorado, 80538, United States

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Medical College of Wisconsin
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Milwaukee, Wisconsin, 53226, United States

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Medical Oncology Hematology Consultants PA
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Newark, Delaware, 19713, United States

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Memorial Hospital East
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Shiloh, Illinois, 62269, United States

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Memorial Hospital North
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Colorado Springs, Colorado, 80920, United States

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Mercy Cancer Center-West Lakes
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Clive, Iowa, 50325, United States

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Mercy Medical Center - Des Moines
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Des Moines, Iowa, 50314, United States

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Mercy Medical Center-West Lakes
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West Des Moines, Iowa, 50266, United States

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Miller-Dwan Hospital
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Duluth, Minnesota, 55805, United States

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Montefiore Medical Center - Moses Campus
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The Bronx, New York, 10467, United States

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Montefiore Medical Center-Einstein Campus
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The Bronx, New York, 10461, United States

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Mount Sinai Hospital
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New York, New York, 10029, United States

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Nebraska Medicine-Bellevue
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Bellevue, Nebraska, 68123, United States

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Nebraska Medicine-Village Pointe
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Omaha, Nebraska, 68118, United States

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Northwell Health/Center for Advanced Medicine
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Lake Success, New York, 11042, United States

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Northwest Wisconsin Cancer Center
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Ashland, Wisconsin, 54806, United States

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Ohio State University Comprehensive Cancer Center
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Columbus, Ohio, 43210, United States

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Palo Alto Medical Foundation Health Care
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Palo Alto, California, 94301, United States

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Palo Alto Medical Foundation-Camino Division
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Mountain View, California, 94040, United States

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Palo Alto Medical Foundation-Fremont
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Fremont, California, 94538, United States

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Palo Alto Medical Foundation-Sunnyvale
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Sunnyvale, California, 94086, United States

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Poudre Valley Hospital
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Fort Collins, Colorado, 80524, United States

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ProHealth D N Greenwald Center
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Mukwonago, Wisconsin, 53149, United States

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ProHealth Oconomowoc Memorial Hospital
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Oconomowoc, Wisconsin, 53066, United States

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Providence Newberg Medical Center
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Newberg, Oregon, 97132, United States

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Providence Portland Medical Center
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Portland, Oregon, 97213, United States

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Providence Saint Vincent Medical Center
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Portland, Oregon, 97225, United States

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Providence Willamette Falls Medical Center
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Oregon City, Oregon, 97045, United States

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Rocky Mountain Cancer Centers-Penrose
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Colorado Springs, Colorado, 80907, United States

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Saint Mary's Hospital and Regional Medical Center
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Grand Junction, Colorado, 81501, United States

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Siteman Cancer Center at Christian Hospital
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St Louis, Missouri, 63136, United States

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Siteman Cancer Center at Saint Peters Hospital
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City of Saint Peters, Missouri, 63376, United States

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Siteman Cancer Center at West County Hospital
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Creve Coeur, Missouri, 63141, United States

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Siteman Cancer Center-South County
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St Louis, Missouri, 63129, United States

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Smilow Cancer Center/Yale-New Haven Hospital
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New Haven, Connecticut, 06510, United States

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Smilow Cancer Hospital Care Center - Guilford
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Guilford, Connecticut, 06437, United States

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Smilow Cancer Hospital Care Center - Waterford
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Waterford, Connecticut, 06385, United States

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Smilow Cancer Hospital Care Center at Glastonbury
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Glastonbury, Connecticut, 06033, United States

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Smilow Cancer Hospital Care Center at Greenwich
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Greenwich, Connecticut, 06830, United States

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Smilow Cancer Hospital Care Center at Long Ridge
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Stamford, Connecticut, 06902, United States

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Smilow Cancer Hospital Care Center at Saint Francis
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Hartford, Connecticut, 06105, United States

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Smilow Cancer Hospital Care Center-Fairfield
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Fairfield, Connecticut, 06824, United States

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Smilow Cancer Hospital Care Center-Trumbull
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Trumbull, Connecticut, 06611, United States

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Smilow Cancer Hospital-Derby Care Center
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Derby, Connecticut, 06418, United States

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Smilow Cancer Hospital-Hamden Care Center
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Hamden, Connecticut, 06518, United States

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Smilow Cancer Hospital-Torrington Care Center
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Torrington, Connecticut, 06790, United States

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Smilow Cancer Hospital-Waterbury Care Center
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Waterbury, Connecticut, 06708, United States

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Sutter Cancer Centers Radiation Oncology Services-Cameron Park
RECRUITING

Cameron Park, California, 95682, United States

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Sutter Cancer Centers Radiation Oncology Services-Roseville
RECRUITING

Roseville, California, 95661, United States

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Sutter Medical Center Sacramento
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Sacramento, California, 95816, United States

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Sutter Pacific Medical Foundation
RECRUITING

Santa Rosa, California, 95403, United States

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Sutter Roseville Medical Center
RECRUITING

Roseville, California, 95661, United States

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The Iowa Clinic PC
RECRUITING

West Des Moines, Iowa, 50266, United States

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UC Comprehensive Cancer Center at Silver Cross
RECRUITING

New Lenox, Illinois, 60451, United States

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UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

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UCHealth Greeley Hospital
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Greeley, Colorado, 80631, United States

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UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, 80909, United States

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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
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Irvine, California, 92612, United States

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UChicago Medicine Northwest Indiana
RECRUITING

Crown Point, Indiana, 46307, United States

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UH Seidman Cancer Center at Lake Health Mentor Campus
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Mentor, Ohio, 44060, United States

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UH Seidman Cancer Center at UH Avon Health Center
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Avon, Ohio, 44011, United States

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UHHS-Chagrin Highlands Medical Center
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Beachwood, Ohio, 44122, United States

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UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING

Ankeny, Iowa, 50023, United States

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UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITING

Des Moines, Iowa, 50309, United States

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UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING

Des Moines, Iowa, 50314, United States

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UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITING

Waukee, Iowa, 50263, United States

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UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITING

Clive, Iowa, 50325, United States

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UW Cancer Center at ProHealth Care
RECRUITING

Waukesha, Wisconsin, 53188, United States

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University Health Network-Princess Margaret Hospital
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Toronto, Ontario, M5G 2M9, Canada

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University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States

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University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, 60637, United States

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University of Chicago Medicine-Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States

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University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States

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University of Kentucky/Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States

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University of Nebraska Medical Center
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Omaha, Nebraska, 68198, United States

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University of New Mexico Cancer Center
RECRUITING

Albuquerque, New Mexico, 87106, United States

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Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Yale-New Haven Hospital North Haven Medical Center
RECRUITING

North Haven, Connecticut, 06473, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••

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