Smart drugs take on rare salivary gland cancer in new trial

NCT ID NCT05408845

Recruiting now Disease control Sponsor: NRG Oncology Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial is testing whether newer targeted drugs (trastuzumab emtansine and trastuzumab deruxtecan) work better than standard chemotherapy plus trastuzumab for people with HER2-positive or HER2-low salivary gland cancer that has come back, spread, or cannot be removed. About 146 participants will be enrolled. The goal is to see if these antibody-drug conjugates can slow tumor growth or shrink tumors more effectively.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Trastuzumab emtansine (T-DM1) and trastuzumab deruxtecan, along with docetaxel chemotherapy
What this could lead to: If successful, this trial could point toward more effective, targeted treatment options for people with HER2-positive or HER2-low salivary gland cancer that has spread or cannot be removed.
What could go wrong: This is a mid-stage (phase II) trial with 146 participants, so results are not definitive. The newer drugs may not work better than standard therapy, and side effects from the chemotherapy-linked antibodies can be serious.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major salivary gland cancer major salivary gland carcinoma salivary gland cancer salivary gland carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC SALIVARY GLAND CARCINOMA RECURRENT SALIVARY GLAND CARCINOMA STAGE III MAJOR SALIVARY GLAND CANCER AJCC V8 STAGE IV MAJOR SALIVARY GLAND CANCER AJCC V8 UNRESECTABLE SALIVARY GLAND CARCINOMA

Contacts and locations

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Locations

Abbott-Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States
Arnold Palmer Cancer Center Medical Oncology Norwin
RECRUITING

N. Huntingdon, Pennsylvania, 15642, United States

Contact Email: •••••@•••••
Boston Medical Center
RECRUITING

Boston, Massachusetts, 02118, United States
Broadlawns Medical Center
RECRUITING

Des Moines, Iowa, 50314, United States
Cancer Centers of Southwest Oklahoma Research
RECRUITING

Lawton, Oklahoma, 73505, United States
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact Email: •••••@•••••
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Email: •••••@•••••
Carlisle Regional Cancer Center
RECRUITING

Carlisle, Pennsylvania, 17015, United States
City of Hope Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

Duarte, California, 91010, United States
City of Hope at Irvine Lennar
ACTIVE_NOT_RECRUITING

Irvine, California, 92618, United States
Dartmouth Cancer Center - North
SUSPENDED

Saint Johnsbury, Vermont, 05819, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Divine Providence Hospital
RECRUITING

Williamsport, Pennsylvania, 17754, United States
Emory University Hospital Midtown
RECRUITING

Atlanta, Georgia, 30308, United States
Fairview Southdale Hospital
RECRUITING

Edina, Minnesota, 55435, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
HaysMed
RECRUITING

Hays, Kansas, 67601, United States
Hennepin County Medical Center
RECRUITING

Minneapolis, Minnesota, 55415, United States
Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

Contact Email: •••••@•••••
IRMC Cancer Center
RECRUITING

Indiana, Pennsylvania, 15701, United States
Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States
Kaiser Permanente Downtown Commons
RECRUITING

Sacramento, California, 95814, United States
Kaiser Permanente Dublin
RECRUITING

Dublin, California, 94568, United States
Kaiser Permanente Fresno Orchard Plaza
RECRUITING

Fresno, California, 93720, United States
Kaiser Permanente Medical Center - Santa Clara
RECRUITING

Santa Clara, California, 95051, United States
Kaiser Permanente Moanalua Medical Center
RECRUITING

Honolulu, Hawaii, 96819, United States
Kaiser Permanente San Leandro
RECRUITING

San Leandro, California, 94577, United States
Kaiser Permanente- Modesto MOB II
RECRUITING

Modesto, California, 95356, United States
Kaiser Permanente-Fremont
RECRUITING

Fremont, California, 94538, United States
Kaiser Permanente-Fresno
RECRUITING

Fresno, California, 93720, United States
Kaiser Permanente-Modesto
RECRUITING

Modesto, California, 95356, United States
Kaiser Permanente-Oakland
RECRUITING

Oakland, California, 94611, United States
Kaiser Permanente-Roseville
RECRUITING

Roseville, California, 95661, United States
Kaiser Permanente-San Francisco
RECRUITING

San Francisco, California, 94115, United States
Kaiser Permanente-Santa Rosa
RECRUITING

Santa Rosa, California, 95403, United States
Kaiser Permanente-Santa Teresa-San Jose
RECRUITING

San Jose, California, 95119, United States
Kaiser Permanente-South Sacramento
RECRUITING

Sacramento, California, 95823, United States
Kaiser Permanente-South San Francisco
RECRUITING

South San Francisco, California, 94080, United States
Kaiser Permanente-Vallejo
RECRUITING

Vallejo, California, 94589, United States
Kaiser Permanente-Walnut Creek
RECRUITING

Walnut Creek, California, 94596, United States
Kaiser San Rafael-Gallinas
RECRUITING

San Rafael, California, 94903, United States
Lawrence Memorial Hospital
RECRUITING

Lawrence, Kansas, 66044, United States
Marshfield Medical Center - Minocqua
RECRUITING

Minocqua, Wisconsin, 54548, United States

Contact Email: •••••@•••••
Marshfield Medical Center - Weston
RECRUITING

Weston, Wisconsin, 54476, United States

Contact Email: •••••@•••••
Marshfield Medical Center-EC Cancer Center
RECRUITING

Eau Claire, Wisconsin, 54701, United States

Contact Email: •••••@•••••
Marshfield Medical Center-Marshfield
RECRUITING

Marshfield, Wisconsin, 54449, United States

Contact Email: •••••@•••••
Marshfield Medical Center-Rice Lake
RECRUITING

Rice Lake, Wisconsin, 54868, United States

Contact Email: •••••@•••••
Marshfield Medical Center-River Region at Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54482, United States

Contact Email: •••••@•••••
Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
McFarland Clinic - Ames
ACTIVE_NOT_RECRUITING

Ames, Iowa, 50010, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Hospital East
RECRUITING

Shiloh, Illinois, 62269, United States
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States
Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States
Mercy Medical Center - Des Moines
RECRUITING

Des Moines, Iowa, 50314, United States
Miami Cancer Institute
RECRUITING

Miami, Florida, 33176, United States
Mount Sinai Chelsea
ACTIVE_NOT_RECRUITING

New York, New York, 10011, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Park Nicollet Clinic - Saint Louis Park
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
ProHealth D N Greenwald Center
RECRUITING

Mukwonago, Wisconsin, 53149, United States
ProHealth Oconomowoc Memorial Hospital
RECRUITING

Oconomowoc, Wisconsin, 53066, United States
Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Saint Anthony Regional Hospital
RECRUITING

Carroll, Iowa, 51401, United States
Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland
RECRUITING

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian
RECRUITING

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa
RECRUITING

Nampa, Idaho, 83687, United States
Saint Luke's Cancer Institute - Twin Falls
RECRUITING

Twin Falls, Idaho, 83301, United States
Salina Regional Health Center
RECRUITING

Salina, Kansas, 67401, United States
Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

Contact Email: •••••@•••••
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

Contact Email: •••••@•••••
Sanford Joe Lueken Cancer Center
RECRUITING

Bemidji, Minnesota, 56601, United States

Contact Email: •••••@•••••
Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

Contact Email: •••••@•••••
Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

Contact Email: •••••@•••••
Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

Contact Email: •••••@•••••
Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

Contact Email: •••••@•••••
Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

Contact Email: •••••@•••••
Stanford Cancer Institute Palo Alto
RECRUITING

Palo Alto, California, 94304, United States
Swedish Cancer Institute-Issaquah
RECRUITING

Issaquah, Washington, 98029, United States
The Iowa Clinic PC
RECRUITING

West Des Moines, Iowa, 50266, United States
The University of Kansas Cancer Center - Olathe
RECRUITING

Olathe, Kansas, 66061, United States

Contact Email: •••••@•••••
Trinity's Tony Teramana Cancer Center
RECRUITING

Steubenville, Ohio, 43952, United States
UCHealth Highlands Ranch Hospital
RECRUITING

Highlands Ranch, Colorado, 80129, United States
UCHealth University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
UCSF Medical Center-Mission Bay
SUSPENDED

San Francisco, California, 94158, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITING

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITING

Waukee, Iowa, 50263, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITING

Clive, Iowa, 50325, United States
UI Healthcare Mission Cancer and Blood - Fort Dodge
RECRUITING

Fort Dodge, Iowa, 50501, United States

Contact Email: •••••@•••••
UPMC Altoona
RECRUITING

Altoona, Pennsylvania, 16601, United States
UPMC Camp Hill
ACTIVE_NOT_RECRUITING

Camp Hill, Pennsylvania, 17011, United States
UPMC Cancer Center at UPMC Horizon
RECRUITING

Farrell, Pennsylvania, 16121, United States
UPMC Cancer Center at UPMC McKeesport
RECRUITING

McKeesport, Pennsylvania, 15132, United States
UPMC Cancer Center at UPMC Northwest
RECRUITING

Seneca, Pennsylvania, 16346, United States
UPMC Cancer Center-Natrona Heights
RECRUITING

Natrona Heights, Pennsylvania, 15065, United States
UPMC Cancer Center-Uniontown
RECRUITING

Uniontown, Pennsylvania, 15401, United States
UPMC Cancer Center-Washington
RECRUITING

Washington, Pennsylvania, 15301, United States
UPMC Cancer Centers - Arnold Palmer Pavilion
RECRUITING

Greensburg, Pennsylvania, 15601, United States
UPMC Hillman Cancer Center - Monroeville
RECRUITING

Monroeville, Pennsylvania, 15146, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center - New Castle
RECRUITING

New Castle, Pennsylvania, 16105, United States
UPMC Hillman Cancer Center - Part of Frick Hospital
RECRUITING

Mount Pleasant, Pennsylvania, 15666, United States
UPMC Hillman Cancer Center - Passavant - Cranberry
RECRUITING

Cranberry Township, Pennsylvania, 16066, United States
UPMC Hillman Cancer Center Erie
RECRUITING

Erie, Pennsylvania, 16505, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center at Butler Health System
RECRUITING

Butler, Pennsylvania, 16001, United States
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
RECRUITING

Mechanicsburg, Pennsylvania, 17050, United States
UPMC Hillman Cancer Center in Coraopolis
RECRUITING

Moon Township, Pennsylvania, 15108, United States
UPMC Memorial
RECRUITING

York, Pennsylvania, 17408, United States
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
RECRUITING

Harrisburg, Pennsylvania, 17109, United States
UPMC Western Maryland
RECRUITING

Cumberland, Maryland, 21502, United States
UPMC-Heritage Valley Health System Beaver
RECRUITING

Beaver, Pennsylvania, 15009, United States
UPMC-Johnstown/John P. Murtha Regional Cancer Center
RECRUITING

Johnstown, Pennsylvania, 15901, United States
UPMC-Mercy Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15219, United States
UPMC-Passavant Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15237, United States
UPMC-Saint Clair Hospital Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15243, United States
UPMC-Saint Margaret
RECRUITING

Pittsburgh, Pennsylvania, 15215, United States
UW Cancer Center at ProHealth Care
RECRUITING

Waukesha, Wisconsin, 53188, United States
United Hospital
RECRUITING

Saint Paul, Minnesota, 55102, United States
University Health Truman Medical Center
RECRUITING

Kansas City, Missouri, 64108, United States
University of Alabama at Birmingham Cancer Center
ACTIVE_NOT_RECRUITING

Birmingham, Alabama, 35233, United States
University of Cincinnati Cancer Center-UC Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States

Contact Email: •••••@•••••
University of Cincinnati Cancer Center-West Chester
RECRUITING

West Chester, Ohio, 45069, United States

Contact Email: •••••@•••••
University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Lee's Summit
RECRUITING

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North
RECRUITING

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center-Overland Park
RECRUITING

Overland Park, Kansas, 66210, United States
University of Kansas Health System Saint Francis Campus
RECRUITING

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Indian Creek Campus
RECRUITING

Overland Park, Kansas, 66211, United States
University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Kentucky/Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Michigan Rogel Cancer Center
RECRUITING

Ann Arbor, Michigan, 48109, United States

Contact Email: •••••@•••••
University of New Mexico Cancer Center
RECRUITING

Albuquerque, New Mexico, 87106, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Pittsburgh Cancer Institute (UPCI)
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Vanderbilt University/Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••
Wayne State University/Karmanos Cancer Institute
ACTIVE_NOT_RECRUITING

Detroit, Michigan, 48201, United States
Weisberg Cancer Treatment Center
ACTIVE_NOT_RECRUITING

Farmington Hills, Michigan, 48334, United States

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