New study aims to reduce leg swelling in endometrial cancer surgery

NCT ID NCT05646316

Recruiting now Symptom relief Sponsor: NRG Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study tests whether a less invasive lymph node procedure (sentinel mapping) can lower the risk of long-term leg swelling compared to standard lymph node removal. About 428 women with stage I endometrial cancer will be followed for 18 months after hysterectomy. The goal is to find which method better preserves leg function and quality of life.

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Conditions

The condition(s) this trial relates to.

carcinosarcoma stage I endometrioid carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STAGE I UTERINE CORPUS CARCINOMA OR CARCINOSARCOMA AJCC V8

Contacts and locations

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Locations

Alegent Health Bergan Mercy Medical Center
ACTIVE_NOT_RECRUITING

Omaha, Nebraska, 68124, United States
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Augusta University Medical Center
RECRUITING

Augusta, Georgia, 30912, United States
Bryn Mawr Hospital
SUSPENDED

Bryn Mawr, Pennsylvania, 19010, United States
East Jefferson General Hospital
RECRUITING

Metairie, Louisiana, 70006, United States
Ewha Woman's University Mokdong Hospital
RECRUITING

Seoul, 07985, South Korea
Fairview Clinics and Surgery Center Maple Grove
RECRUITING

Maple Grove, Minnesota, 55369, United States
Fairview Lakes Medical Center
RECRUITING

Wyoming, Minnesota, 55092, United States
Fairview Northland Medical Center
RECRUITING

Princeton, Minnesota, 55371, United States
Fairview Southdale Hospital
RECRUITING

Edina, Minnesota, 55435, United States
Fred and Pamela Buffett Cancer Center - Kearney
RECRUITING

Kearney, Nebraska, 68845, United States
Gachon University Gil Hospital
RECRUITING

Incheon, 405-760, South Korea
Gangnam Severance Hospital
RECRUITING

Seoul, 06273, South Korea
George Washington University Medical Center
SUSPENDED

Washington D.C., District of Columbia, 20037, United States
Houston Methodist Hospital
ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
Houston Methodist Sugar Land Hospital
ACTIVE_NOT_RECRUITING

Sugar Land, Texas, 77479, United States
Houston Methodist The Woodlands Hospital
ACTIVE_NOT_RECRUITING

The Woodlands, Texas, 77385, United States
Houston Methodist West Hospital
ACTIVE_NOT_RECRUITING

Houston, Texas, 77094, United States
IU Health North Hospital
RECRUITING

Carmel, Indiana, 46032, United States

Contact Email: •••••@•••••
Indiana University/Melvin and Bren Simon Cancer Center
RECRUITING

Indianapolis, Indiana, 46202, United States

Contact Email: •••••@•••••
Intermountain Health West End Clinic
ACTIVE_NOT_RECRUITING

Billings, Montana, 59106, United States
LSU Healthcare Network / Metairie Multi-Specialty Clinic
RECRUITING

Metairie, Louisiana, 70006, United States
Lankenau Medical Center
SUSPENDED

Wynnewood, Pennsylvania, 19096, United States
Louisiana State University Health Science Center
RECRUITING

New Orleans, Louisiana, 70112, United States
McLaren Cancer Institute-Flint
RECRUITING

Flint, Michigan, 48532, United States

Contact Email: •••••@•••••
Memorial Hermann Texas Medical Center
RECRUITING

Houston, Texas, 77030, United States
Mercy Hospital Springfield
RECRUITING

Springfield, Missouri, 65804, United States
Methodist Willowbrook Hospital
ACTIVE_NOT_RECRUITING

Houston, Texas, 77070, United States
Nebraska Medicine-Village Pointe
RECRUITING

Omaha, Nebraska, 68118, United States
Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Paoli Memorial Hospital
SUSPENDED

Paoli, Pennsylvania, 19301, United States
Parkland Memorial Hospital
RECRUITING

Dallas, Texas, 75235, United States

Contact Email: •••••@•••••
Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Saint James Community Hospital and Cancer Treatment Center
ACTIVE_NOT_RECRUITING

Butte, Montana, 59701, United States
Saint John's Hospital - Healtheast
RECRUITING

Maplewood, Minnesota, 55109, United States
Saint Vincent Frontier Cancer Center
ACTIVE_NOT_RECRUITING

Billings, Montana, 59102, United States
Saint Vincent Healthcare
ACTIVE_NOT_RECRUITING

Billings, Montana, 59101, United States
Samsung Changwon Hospital
SUSPENDED

Seoul, Gyeongsangnam-do, 51353, South Korea
UM Sylvester Comprehensive Cancer Center at Coral Gables
RECRUITING

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Doral
RECRUITING

Doral, Florida, 33166, United States
UM Sylvester Comprehensive Cancer Center at Kendall
RECRUITING

Miami, Florida, 33176, United States
UM Sylvester Comprehensive Cancer Center at Plantation
RECRUITING

Plantation, Florida, 33324, United States
UM Upper Chesapeake Medical Center
RECRUITING

Bel Air, Maryland, 21014, United States
UT Southwestern Clinical Center at Richardson/Plano
RECRUITING

Richardson, Texas, 75080, United States
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Email: •••••@•••••
University Medical Center New Orleans
RECRUITING

New Orleans, Louisiana, 70112, United States
University of Maryland/Greenebaum Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
RECRUITING

North Miami, Florida, 33181, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States

Contact Email: •••••@•••••
Wayne State University/Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States

Contact Email: •••••@•••••
Weisberg Cancer Treatment Center
RECRUITING

Farmington Hills, Michigan, 48334, United States

Contact Email: •••••@•••••
West Jefferson Medical Center
RECRUITING

Marrero, Louisiana, 70072, United States
Women and Infants Hospital
RECRUITING

Providence, Rhode Island, 02905, United States
Women's Cancer Center of Nevada
RECRUITING

Las Vegas, Nevada, 89106, United States

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