Nrg Oncology

This study looks at whether a blood test that finds tiny bits of tumor DNA (ctDNA) after colon cancer surgery can help doctors choose the right chemotherapy. About 1,900 people with stage III colon cancer will join. The goal is to see if using this test leads to better cancer con…

This study tests whether taking the drug olaparib for one year works as well as taking it for two years to keep ovarian cancer from coming back. Participants have a specific genetic type of advanced ovarian cancer (BRCA mutation or HRD positive) and have already responded to init…

This study is for women with stage I, hormone-sensitive breast cancer. It compares two treatments after lumpectomy: hormone therapy alone versus hormone therapy plus radiation. The goal is to see if skipping radiation is just as effective at preventing cancer from coming back in …

This study tests whether adding a precise, high-dose radiation treatment (SBRT) to the tumor before standard chemoradiation and immunotherapy can help people with locally advanced lung cancer live longer. About 474 adults whose lung cancer has spread to nearby lymph nodes but can…

This study compares two types of radiation for people with small cell lung cancer that has spread to the brain. One method uses a precise, high-dose beam to each tumor, while the other treats the whole brain but avoids the memory center. The goal is to see which approach better p…

This study tests if a precise type of proton radiation (pCSI) can help people with breast or lung cancer that has spread to the fluid-filled space around the brain and spinal cord live longer than standard x-ray radiation. About 115 participants will be randomly assigned to one o…

This study tests whether newer targeted therapies can better control advanced salivary gland cancer that has spread or cannot be removed. About 146 adults with HER2-positive or HER2-low tumors will receive either standard chemo plus trastuzumab or one of two antibody-drug conjuga…

This study compares a new, shorter radiation treatment (5 sessions over 2 weeks) to the standard longer treatment (20-45 sessions over 4-9 weeks) for men with high-risk prostate cancer. The goal is to see if the shorter approach is just as effective at preventing the cancer from …

This study looks at whether giving radiation therapy after complete removal of a grade II meningioma (a type of brain tumor) helps keep the tumor from coming back, compared to just watching and waiting. About 163 people with newly diagnosed, fully removed tumors will be randomly …

This study tests whether giving a higher dose of radiation can help people with locally advanced pancreatic cancer live longer. Participants must have already had 4-6 months of chemotherapy. The trial compares higher-dose radiation to standard care (more chemo, observation, or lo…

This study is for people with advanced liver cancer that has spread to nearby blood vessels. It compares standard immunotherapy drugs alone versus immunotherapy plus precise, high-dose radiation (SBRT) to the liver tumor. The goal is to see if adding radiation helps patients live…

This study compares two types of surgery for early-stage oral cavity cancer: a newer, less invasive approach called sentinel lymph node biopsy that removes only a few key lymph nodes, versus the standard elective neck dissection that removes many lymph nodes. The goal is to see i…

This study tests whether adding a drug called apalutamide to standard hormone therapy and radiation can keep prostate cancer from spreading in people whose cancer was found in lymph nodes after prostate removal surgery. About 586 participants will be randomly assigned to get eith…

This study is for premenopausal women with a common type of early-stage breast cancer (ER-positive, HER2-negative) that has a low risk of coming back. It compares two treatment plans: hormone therapy alone versus hormone therapy plus chemotherapy. The goal is to see if adding che…

This study compares two radiation techniques for people with stage I to IVA esophageal cancer: proton beam therapy (PBT) and intensity modulated photon radiotherapy (IMRT). The goal is to see which one helps patients live longer and causes fewer serious heart and lung side effect…

This study is for people with advanced kidney cancer that has spread and cannot be removed by surgery. It tests whether adding a precise, high-dose form of radiation (SABR) to the main tumor, alongside standard immunotherapy drugs, can better control the cancer and delay its grow…

This study compares two ways of giving radiation therapy for muscle-invasive bladder cancer. One group gets the usual number of radiation sessions (hypofractionation) and the other gets even fewer, higher-dose sessions (ultra-hypofractionation), both combined with standard chemot…

This study looks at whether people who had 1 or 2 small, non-cancerous polyps removed can safely wait 10 years for their next colonoscopy instead of the usual 5 years. About 9,500 adults aged 45-69 will be randomly assigned to have a colonoscopy at 5 and 10 years or only at 10 ye…

This study looks at two surgeries for women with BRCA1 gene changes who are at high risk for ovarian cancer. One surgery removes only the fallopian tubes, while the other removes both tubes and ovaries. The goal is to see if removing just the tubes works nearly as well at prevent…

This study tests if computerized brain training can improve memory and thinking problems in breast cancer survivors. About 386 women who had breast cancer and report mental fogginess will be randomly assigned to either a brain training program or a placebo. The goal is to see if …

This study tests whether adding BMX-001 to standard care can reduce severe mouth sores caused by chemoradiation in head and neck cancer patients. About 98 participants will receive either BMX-001 or a placebo alongside their usual treatment. The goal is to improve quality of life…

This study looks at 428 people with stage I endometrial cancer who are having a hysterectomy. It compares two ways to check if cancer has spread to lymph nodes: the standard method (removing many lymph nodes) versus a newer method (using dye to find and remove only the key nodes)…

This study tests whether giving radiation in three smaller doses (fractionated SRS) is better than a single large dose (standard SRS) for treating cancer that has spread to the brain. About 269 adults with certain cancers (like lung, breast, or melanoma) will be enrolled. The goa…

This study tests two online mindfulness programs for younger breast cancer survivors (diagnosed at or before age 50) who have finished primary treatment and feel depressed. One program is a live class over Zoom, the other is a self-paced app. The goal is to see which approach bet…

This study tests two ways to help people on oral cancer drugs manage symptoms and emotional distress. One method uses automated phone calls to track symptoms and alert doctors. The other adds a self-help handbook and counseling for those feeling anxious or sad. The goal is to red…