New proton therapy could outshine standard radiation for deadly cancer complication
NCT ID NCT06500481
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase III trial tests whether proton craniospinal irradiation (pCSI) can improve survival compared to standard involved-field radiation therapy (IFRT) for patients with breast or non-small cell lung cancer that has spread to the lining of the brain and spinal cord (leptomeningeal metastasis). About 115 participants will be randomly assigned to receive either pCSI or IFRT. The study aims to see if the more precise proton beam can delay disease worsening and extend life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Proton craniospinal irradiation (pCSI) and involved-field radiation therapy (IFRT)
What this could lead to
If pCSI works better, it could offer a new standard treatment that delays worsening of leptomeningeal metastasis and improves survival for patients with breast or lung cancer.
What could go wrong
This is an early-stage phase III trial with only 115 participants, so results may not apply to all patients. Proton therapy is not widely available, and there may be side effects from radiating the entire central nervous system.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alton Memorial Hospital
RECRUITINGAlton, Illinois, 62002, United States
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California Protons Cancer Therapy Center
RECRUITINGSan Diego, California, 92121, United States
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Huntsman Cancer Institute/University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
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Inova Alexandria Hospital
RECRUITINGAlexandria, Virginia, 22304, United States
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Inova Fair Oaks Hospital
RECRUITINGFairfax, Virginia, 22033, United States
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Inova Loudoun Hospital
RECRUITINGLeesburg, Virginia, 20176, United States
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Inova Schar Cancer Institute
RECRUITINGFairfax, Virginia, 22031, United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITINGBaltimore, Maryland, 21287, United States
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Karmanos Cancer Institute at McLaren Greater Lansing
RECRUITINGLansing, Michigan, 48910, United States
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Laura and Isaac Perlmutter Cancer Center at NYU Langone
RECRUITINGNew York, New York, 10016, United States
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Mayo Clinic Hospital in Arizona
RECRUITINGPhoenix, Arizona, 85054, United States
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
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McLaren Cancer Institute-Flint
RECRUITINGFlint, Michigan, 48532, United States
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Memorial Hospital East
RECRUITINGShiloh, Illinois, 62269, United States
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Memorial Sloan Kettering Basking Ridge
RECRUITINGBasking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen
RECRUITINGMontvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Memorial Sloan Kettering Commack
RECRUITINGCommack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth
RECRUITINGMiddletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau
RECRUITINGUniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester
RECRUITINGHarrison, New York, 10604, United States
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Mercy Hospital South
RECRUITINGSt Louis, Missouri, 63128, United States
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Mercy Hospital Springfield
RECRUITINGSpringfield, Missouri, 65804, United States
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Miami Cancer Institute
RECRUITINGMiami, Florida, 33176, United States
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Montefiore Medical Center - Moses Campus
RECRUITINGThe Bronx, New York, 10467, United States
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Montefiore Medical Center-Einstein Campus
RECRUITINGThe Bronx, New York, 10461, United States
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NYU Langone Hospital - Brooklyn
RECRUITINGBrooklyn, New York, 11220, United States
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NYU Langone Hospital - Long Island
RECRUITINGMineola, New York, 11501, United States
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New York Proton Center
RECRUITINGNew York, New York, 10035, United States
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Northwestern Medicine Cancer Center Delnor
RECRUITINGGeneva, Illinois, 60134, United States
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Northwestern Medicine Cancer Center Kishwaukee
RECRUITINGDeKalb, Illinois, 60115, United States
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Northwestern Medicine Cancer Center Warrenville
RECRUITINGWarrenville, Illinois, 60555, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
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Sibley Memorial Hospital
RECRUITINGWashington D.C., District of Columbia, 20016, United States
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Siteman Cancer Center at Christian Hospital
RECRUITINGSt Louis, Missouri, 63136, United States
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Siteman Cancer Center at Saint Peters Hospital
RECRUITINGCity of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center at West County Hospital
RECRUITINGCreve Coeur, Missouri, 63141, United States
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Siteman Cancer Center-South County
RECRUITINGSt Louis, Missouri, 63129, United States
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UC San Diego Health System - Encinitas
RECRUITINGEncinitas, California, 92024, United States
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UC San Diego Medical Center - Hillcrest
RECRUITINGSan Diego, California, 92103, United States
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UC San Diego Moores Cancer Center
RECRUITINGLa Jolla, California, 92093, United States
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UM Sylvester Comprehensive Cancer Center at Aventura
RECRUITINGAventura, Florida, 33180, United States
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UM Sylvester Comprehensive Cancer Center at Coral Gables
RECRUITINGCoral Gables, Florida, 33146, United States
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UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITINGDeerfield Beach, Florida, 33442, United States
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UM Sylvester Comprehensive Cancer Center at Doral
RECRUITINGDoral, Florida, 33166, United States
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UM Sylvester Comprehensive Cancer Center at Kendall
RECRUITINGMiami, Florida, 33176, United States
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UM Sylvester Comprehensive Cancer Center at Plantation
RECRUITINGPlantation, Florida, 33324, United States
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University of Arkansas for Medical Sciences
RECRUITINGLittle Rock, Arkansas, 72205, United States
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University of Kansas Cancer Center
RECRUITINGKansas City, Kansas, 66160, United States
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University of Kansas Cancer Center - Lee's Summit
RECRUITINGLee's Summit, Missouri, 64064, United States
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University of Kansas Cancer Center - North
RECRUITINGKansas City, Missouri, 64154, United States
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University of Kansas Cancer Center-Overland Park
RECRUITINGOverland Park, Kansas, 66210, United States
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University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITINGMiami, Florida, 33136, United States
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
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Wayne State University/Karmanos Cancer Institute
RECRUITINGDetroit, Michigan, 48201, United States
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Weisberg Cancer Treatment Center
RECRUITINGFarmington Hills, Michigan, 48334, United States
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