ANATOMIC STAGE IV BREAST CANCER AJCC V8
Clinical trials for ANATOMIC STAGE IV BREAST CANCER AJCC V8 explained in plain language.
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New vaccine aims to train immune system against aggressive breast cancer
⭐️ VACCINE ⭐️ Recruiting nowThis study tests a vaccine called STEMVAC, given with chemotherapy, for people with a hard-to-treat breast cancer that has spread. The vaccine is designed to teach the immune system to attack cancer stem cells. About 20 adults with PD-L1 negative, metastatic triple-negative breas…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: ⭐️ VACCINE ⭐️
Last updated May 16, 2026 23:56 UTC
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Custom-Made vaccine targets tough cancers in early trial
⭐️ VACCINE ⭐️ Recruiting nowThis early-phase study is testing a personalized vaccine made from each patient's unique tumor mutations. The goal is to see if it is safe and can help the immune system fight advanced breast cancer, melanoma, and non-small cell lung cancer. About 25 adults whose cancers have spr…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: Fred Hutchinson Cancer Center • Aim: ⭐️ VACCINE ⭐️
Last updated May 11, 2026 20:52 UTC
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Custom-Made vaccine takes on tough breast cancer
⭐️ VACCINE ⭐️ Recruiting nowThis early-stage trial tests a personalized vaccine made from a patient's own tumor, given alone or with drugs that boost the immune system (pembrolizumab or ipilimumab). The goal is to see if the vaccine is safe and can help the immune system fight triple negative breast cancer …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: Emory University • Aim: ⭐️ VACCINE ⭐️
Last updated May 11, 2026 20:37 UTC
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New radiation technique aims to control brain metastases while protecting memory
Disease control Recruiting nowThis study tests a radiation method that treats the entire brain and spinal cord but avoids the hippocampus, a memory center. It is for adults with breast or lung cancer that has spread to the fluid and tissues around the brain and spine. The goal is to see if this approach can d…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated May 17, 2026 00:02 UTC
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Personalized vaccine joins immunotherapy in fight against metastatic breast cancer
Disease control Recruiting nowThis study tests whether adding a personalized vaccine (made from unique tumor proteins) to a combination of chemotherapy and two immunotherapy drugs can better control metastatic triple-negative breast cancer. About 70 participants will be randomly assigned to receive either the…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 16, 2026 23:57 UTC
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New drug cocktail aims to shrink Hard-to-Treat tumors
Disease control Recruiting nowThis early-phase trial tests two drugs—ZEN003694 and abemaciclib—together in people with advanced NUT carcinoma, breast cancer, or other solid tumors that have spread or can't be removed. The main goals are to find the safest dose and see if the combination can shrink or stabiliz…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 16, 2026 23:56 UTC
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New combo therapy targets hard-to-treat breast cancer
Disease control Recruiting nowThis study tests whether adding high-dose radiation to standard immunotherapy (pembrolizumab) and chemotherapy can help people with a specific type of advanced breast cancer (PD-L1 positive, triple-negative) that has spread. About 29 adults will receive the combination treatment.…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Emory University • Aim: Disease control
Last updated May 16, 2026 23:56 UTC
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Measles virus turned against breast cancer tumors in new trial
Disease control Recruiting nowThis early-stage trial tests a modified measles virus (MV-s-NAP) injected directly into tumors of people with metastatic breast cancer. The virus is designed to kill cancer cells and boost the immune system. Researchers aim to find the safest dose and see if it shrinks tumors. Ab…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 16, 2026 23:55 UTC
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New drug targets Hard-to-Treat cancers with specific mutations
Disease control Recruiting nowThis study tests a drug called avapritinib in people with advanced solid tumors that have spread and have specific gene changes (CKIT or PDGFRA mutations). The drug works by blocking enzymes that help cancer cells grow. The goal is to see if avapritinib can shrink or control thes…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 16, 2026 23:55 UTC
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Zapping spots: radiation may buy time for breast cancer patients
Disease control Recruiting nowThis study is for people with metastatic breast cancer whose disease has started to grow in just a few spots while on their current treatment. It tests whether using precise, high-dose radiation on those spots can allow them to keep using their current medication for at least 6 m…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 15, 2026 11:57 UTC
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New proton radiation trial aims to extend survival in advanced cancer patients
Disease control Recruiting nowThis study tests if a precise type of proton radiation (pCSI) can help people with breast or lung cancer that has spread to the fluid-filled space around the brain and spinal cord live longer than standard x-ray radiation. About 115 participants will be randomly assigned to one o…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated May 15, 2026 11:57 UTC
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New drug combo targets Hard-to-Treat breast cancer in small trial
Disease control Recruiting nowThis study tests whether adding tamoxifen (a hormone therapy) to a type of chemotherapy (liposomal doxorubicin) can shrink tumors in people with advanced triple-negative breast cancer that has spread or cannot be removed by surgery. The trial includes 30 adults whose cancer has a…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated May 15, 2026 11:57 UTC
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New vaccine combo aims to control advanced breast cancer
Disease control Recruiting nowThis study tests a vaccine called STEMVAC alongside standard hormone therapy or chemotherapy for people with hormone receptor-positive, HER2-negative breast cancer that has spread. The vaccine is designed to train the immune system to attack cancer cells. The trial will check saf…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated May 15, 2026 11:56 UTC
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New vaccine-immunotherapy combo targets breast cancer brain metastases
Disease control Recruiting nowThis study tests a combination of a dendritic cell vaccine (which trains the immune system to attack cancer) and pembrolizumab (an immunotherapy drug) in people with breast cancer that has spread to the brain. The goal is to see if this treatment can shrink brain tumors. The stud…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated May 15, 2026 11:54 UTC
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Could a parasite drug boost cancer immunotherapy? new trial investigates
Disease control Recruiting nowThis study tests whether adding ivermectin (a common anti-parasite drug) to standard immunotherapy can help shrink tumors in people with metastatic triple-negative breast cancer. About 34 adults whose cancer has spread will receive the combination. The goal is to find the best do…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Yuan Yuan • Aim: Disease control
Last updated May 15, 2026 11:53 UTC
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New radiation approach targets cancer in brain and spinal fluid
Disease control Recruiting nowThis study tests a type of radiation therapy called craniospinal irradiation for people whose breast or lung cancer has spread to the fluid and lining around the brain and spinal cord. The goal is to see if this treatment can help control the cancer in these areas. About 35 adult…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 15, 2026 11:53 UTC
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New triple-drug combo targets hard-to-treat breast cancer in early trial
Disease control Recruiting nowThis early-phase trial is testing whether adding an experimental drug (ZEN003694) to standard immunotherapy (pembrolizumab) and chemotherapy (nab-paclitaxel) is safe and tolerable for people with advanced triple-negative breast cancer that has spread. About 57 participants will r…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 14, 2026 12:05 UTC
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Tailor-Made cancer vaccine shows promise in advanced tumors
Disease control Recruiting nowThis study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors. The goal is to see if this combination is safe and helps the immune system fight cancer more effectively. A…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 14, 2026 12:02 UTC
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New drug duo targets hard-to-treat HER2 cancers in early trial
Disease control Recruiting nowThis early-phase trial tests the safety and best dose of two drugs given together for people with advanced breast cancer or other solid tumors that have a protein called HER2. The drugs are pidnarulex (which stops cancer cells from repairing themselves) and trastuzumab deruxtecan…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 13, 2026 15:58 UTC
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New hope for advanced cancers with DNA repair flaws: PARP inhibitor trial opens
Disease control Recruiting nowThis study tests the drug talazoparib in adults with advanced solid tumors (like breast, prostate, ovarian, pancreatic, or stomach cancer) that have certain gene changes affecting DNA repair. The drug blocks a protein called PARP, which cancer cells need to fix their DNA, potenti…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 12, 2026 13:43 UTC
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New study tests cheaper drug for ovarian suppression in breast cancer
Disease control Recruiting nowThis study compares two drugs, leuprolide and goserelin, to see how well they lower estrogen in premenopausal women with breast cancer. Both drugs stop the ovaries from making estrogen, which can fuel cancer growth. The trial will test if leuprolide works as well as goserelin. Ab…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Michigan Rogel Cancer Center • Aim: Disease control
Last updated May 12, 2026 13:42 UTC
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Electric field device shows promise in taming advanced cancers
Disease control Recruiting nowThis early-phase study tests a wearable device that creates low-intensity electric fields (tumor treating fields) combined with either cabozantinib or a chemo-immunotherapy pair (nab-paclitaxel and atezolizumab) in people with advanced solid tumors in the abdomen or chest. The go…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 11, 2026 20:46 UTC
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Smart dosing trial aims to tame metastatic breast cancer
Disease control Recruiting nowThis study tests a new way of giving the chemotherapy drug capecitabine to people with metastatic ER+ breast cancer. Instead of a fixed dose, the dose is adjusted based on how the tumor responds on scans and blood tests. The goal is to control the cancer for as long as possible w…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 11, 2026 20:40 UTC
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New radiation approach may delay need to switch cancer drugs in advanced breast cancer
Disease control Recruiting nowThis study tests whether a precise type of radiation (SBRT) can allow people with estrogen receptor-positive (ER+) breast cancer that has spread and is starting to grow again to keep using their current medication instead of switching to a new one. About 18 participants will rece…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 11, 2026 20:37 UTC
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New hope for tough breast cancer: early trial combines three drugs
Disease control Recruiting nowThis early-phase study tests a new drug, ASTX727, added to standard chemotherapy and immunotherapy for people with metastatic triple-negative breast cancer that cannot be removed by surgery. The goal is to find the safest dose and see if the combination can shrink or stabilize tu…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 08, 2026 12:01 UTC
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New combo attack on liver tumors in advanced breast cancer shows promise
Disease control Recruiting nowThis study tests whether combining an immunotherapy drug (cemiplimab) with a targeted radiation treatment (Y90 radioembolization) can help control breast cancer that has spread to the liver. About 11 adults with stage IV breast cancer and liver tumors will receive both treatments…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 04, 2026 16:22 UTC
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New hope for seniors: drug combo targets tough breast cancer
Disease control Recruiting nowThis study tests how well older adults (70+) with a certain type of advanced breast cancer tolerate a drug called abemaciclib combined with hormone therapy. Participants have already tried a similar drug that stopped working. The main goal is to track side effects and see if this…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 01, 2026 16:01 UTC
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New hope for hard-to-treat breast cancer: drug combo targets resistance
Disease control Recruiting nowThis study tests whether adding another drug (cediranib or AZD6738) to the PARP inhibitor olaparib can shrink tumors or slow cancer growth in people with advanced BRCA-mutated breast cancer that has stopped responding to PARP inhibitors. About 60 adults with HER2-negative, BRCA-p…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Apr 29, 2026 15:05 UTC
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New scan could reveal hidden brain tumors in breast cancer patients
Diagnosis Recruiting nowThis study tests a special PET/MRI scan that uses a radioactive tracer to find HER2-positive breast cancer that has spread to the brain. Researchers want to see if the scan can show which brain tumors will respond to a standard chemotherapy drug. About 10 women with metastatic br…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE4 • Sponsor: City of Hope Medical Center • Aim: Diagnosis
Last updated May 13, 2026 16:04 UTC
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Smart bag and texts boost pill-taking in advanced breast cancer
Symptom relief Recruiting nowThis study tests whether a connected platform (a special medication bag called WiseBag plus text reminders) helps people with metastatic breast cancer take their CDK4/6 inhibitor pills more consistently. About 410 patients will either use the bag alone or the bag with text alerts…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Symptom relief
Last updated May 17, 2026 00:01 UTC
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Brain tumor radiation showdown: one big dose or three smaller ones?
Symptom relief Recruiting nowThis study tests whether giving radiation in three smaller doses (fractionated SRS) is better than a single large dose (standard SRS) for treating cancer that has spread to the brain. About 269 adults with certain cancers (like lung, breast, or melanoma) will be enrolled. The goa…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: NRG Oncology • Aim: Symptom relief
Last updated May 17, 2026 00:00 UTC
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Can a hair loss drug help breast cancer patients keep their hair?
Symptom relief Recruiting nowThis study tests whether minoxidil (a hair growth drug) can reduce hair loss caused by hormone therapy in breast cancer patients. About 50 women with stage I-IV breast cancer who are on hormone therapy and have noticed hair thinning will take either a pill or apply a solution to …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: EARLY_PHASE1 • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief
Last updated May 14, 2026 12:02 UTC
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Can a PET scan predict breast cancer drug success?
Knowledge-focused Recruiting nowThis study tests whether a special PET scan can predict if a drug combination (abemaciclib plus hormone therapy) will work for people with advanced hormone receptor-positive, HER2-negative breast cancer. About 60 participants will get the treatment and have imaging scans to see i…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Knowledge-focused
Last updated May 16, 2026 23:55 UTC
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700 breast cancer patients enrolled to unlock secrets of CDK4/6 drugs
Knowledge-focused Recruiting nowThis study follows 700 adults with advanced or metastatic breast cancer who are taking CDK4/6 inhibitors. Researchers collect blood, tissue, and fluid samples to learn how the cancer responds and why it sometimes becomes resistant. The goal is to better predict treatment success …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: Roswell Park Cancer Institute • Aim: Knowledge-focused
Last updated May 16, 2026 23:54 UTC
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New PET tracer could reveal hidden cancer response in real time
Knowledge-focused Recruiting nowThis study is testing a special radioactive tracer called [18F]FTT that attaches to a protein (PARP1) found in some breast cancer cells. By using a PET scan, doctors hope to see if the tracer can show how well standard treatments (PARP inhibitors with or without immunotherapy) ar…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: University of Washington • Aim: Knowledge-focused
Last updated May 15, 2026 11:57 UTC
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Scientists use special microscope to peek inside tumors during surgery
Knowledge-focused Recruiting nowThis study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to understand how these vessels work, which could help decide if a patient's tumor is likely to respond to certain trea…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated May 15, 2026 11:55 UTC
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Gene-Guided cancer therapy: a new hope for advanced tumors?
Knowledge-focused Recruiting nowThis study screens patients with advanced solid tumors to find genetic changes in their cancer cells. Based on those results, patients may be matched to a treatment trial that targets their specific tumor mutations. The goal is to improve how doctors choose combination therapies …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated May 15, 2026 11:54 UTC
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Researchers ask: what do advanced breast cancer patients really need?
Knowledge-focused Recruiting nowThis study talks to 50 people with advanced breast cancer to learn what has helped them, what has been hard, and what kind of support they still need. It does not test any new drug or treatment. The goal is to design better supportive care programs for the future.
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated May 14, 2026 12:02 UTC
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New ultrasound marker aims to make breast cancer surgery safer and more precise
Knowledge-focused Recruiting nowThis early-stage study tests a new type of marker that shows up better on ultrasound for people with breast cancer that has spread to lymph nodes. The marker is placed in the affected node to help doctors find and remove it during surgery. The goal is to see if this marker is saf…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated May 13, 2026 15:58 UTC
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Can simple blood tests replace frequent scans for breast cancer patients?
Knowledge-focused Recruiting nowThis study looks at whether using blood tests to decide when to do scans is as good as the usual way of monitoring breast cancer that has spread. About 739 patients will be randomly assigned to either blood test monitoring or standard care. The goal is to see if survival is simil…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: SWOG Cancer Research Network • Aim: Knowledge-focused
Last updated May 11, 2026 20:53 UTC
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Mayo clinic study seeks immune clues in HER2 breast cancer patients
Knowledge-focused Recruiting nowThis study collects blood and tumor tissue from 230 adults with HER2-positive breast cancer (stages I-IV) who are starting anti-HER2 drugs like trastuzumab. Researchers want to learn how the immune system responds to these treatments. The goal is to better understand the connecti…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated May 04, 2026 16:23 UTC
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Electric field device tested for spine cancer spread
Knowledge-focused Recruiting nowThis study tests whether a portable device that creates electric fields is safe and practical for treating cancer that has spread to the lining of the spine. It includes up to 5 adults with breast or lung cancer that has spread to the spinal fluid and spine. The goal is to see if…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Apr 26, 2026 19:35 UTC