Targeted pill shows promise for hard-to-treat cancers with rare mutations

NCT ID NCT04771520

First seen Mar 07, 2026 · Last updated May 01, 2026 · Updated 5 times

Summary

This study tests a drug called avapritinib in people with advanced solid tumors that have certain genetic changes (CKIT or PDGFRA mutations). The goal is to see if the drug can shrink or control the cancer. About 50 adults with cancers like melanoma, sarcoma, or breast, lung, or stomach cancer that have spread will take the pill. The drug works by blocking enzymes that help cancer cells grow.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • M D Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.

ANATOMIC STAGE IV BREAST CANCER AJCC V8 CLINICAL STAGE IV GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE IV GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE IVA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE IVA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 CLINICAL STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM LOCALLY ADVANCED MELANOMA LOCALLY ADVANCED PRIMARY MALIGNANT CENTRAL NERVOUS SYSTEM NEOPLASM LOCALLY ADVANCED SARCOMA METASTATIC MALIGNANT SOLID NEOPLASM METASTATIC MELANOMA METASTATIC PRIMARY MALIGNANT CENTRAL NERVOUS SYSTEM NEOPLASM METASTATIC SARCOMA PATHOLOGIC STAGE IV GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IV GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IV GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IV GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PROGNOSTIC STAGE IIIC BREAST CANCER AJCC V8 PROGNOSTIC STAGE IV BREAST CANCER AJCC V8 STAGE IIIC COLORECTAL CANCER AJCC V8 STAGE IIIC COLORECTAL CANCER AJCC V8 STAGE IIIC LUNG CANCER AJCC V8 STAGE IIIC LUNG CANCER AJCC V8 STAGE IV COLORECTAL CANCER AJCC V8 STAGE IV COLORECTAL CANCER AJCC V8 STAGE IV LUNG CANCER AJCC V8 STAGE IV LUNG CANCER AJCC V8 STAGE IVA COLORECTAL CANCER AJCC V8 STAGE IVA COLORECTAL CANCER AJCC V8 STAGE IVA LUNG CANCER AJCC V8 STAGE IVA LUNG CANCER AJCC V8 STAGE IVB COLORECTAL CANCER AJCC V8 STAGE IVB COLORECTAL CANCER AJCC V8 STAGE IVB LUNG CANCER AJCC V8 STAGE IVB LUNG CANCER AJCC V8 STAGE IVC COLORECTAL CANCER AJCC V8