Can a new blood test spot colorectal cancer return earlier?

NCT ID NCT07125729

Recruiting now Diagnosis Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial compares two blood tests—Haystack and Signatera—that look for tiny traces of tumor DNA in the blood after surgery for stage II-IV colorectal cancer. The goal is to see which test is better at detecting minimal residual disease, which could signal that cancer may come back. Adults with resectable colorectal cancer who have had or will have curative surgery are eligible. The study measures how accurately each test predicts recurrence and how early they detect it compared to standard imaging.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Blood-based minimal residual disease (MRD) testing using the Haystack assay compared to the Signatera assay
What this could lead to: If Haystack proves more sensitive, it could enable earlier detection of colorectal cancer recurrence after surgery, potentially improving chances of curative treatment.
What could go wrong: This is an early comparison study, not a treatment trial. The Haystack test may not outperform Signatera in real-world settings, and results may not change patient outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal carcinoma colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESECTABLE COLORECTAL CARCINOMA STAGE II COLORECTAL CANCER AJCC V8 STAGE III COLORECTAL CANCER AJCC V8 STAGE IV COLORECTAL CANCER AJCC V8

Contacts and locations

Locations

CTCA at Western Regional Medical Center
RECRUITING

Goodyear, Arizona, 85338, United States
City of Hope Antelope Valley
RECRUITING

Lancaster, California, 93534, United States
City of Hope Atlanta Cancer Center
RECRUITING

Newnan, Georgia, 30265, United States
City of Hope Comprehensive Cancer Center
RECRUITING

Duarte, California, 91010, United States
City of Hope Corona
RECRUITING

Corona, California, 92882, United States
City of Hope Seacliff
RECRUITING

Huntington Beach, California, 92648, United States
City of Hope South Bay
RECRUITING

Torrance, California, 90503, United States
City of Hope South Pasadena
RECRUITING

South Pasadena, California, 91030, United States
City of Hope Upland
RECRUITING

Upland, California, 91786, United States
City of Hope at Chicago
RECRUITING

Zion, Illinois, 60099, United States
City of Hope at Irvine Lennar
RECRUITING

Irvine, California, 92618, United States
City of Hope at Long Beach Elm
RECRUITING

Long Beach, California, 90813, United States
City of Hope at Newport Beach Fashion Island
RECRUITING

Newport Beach, California, 92660, United States

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