METASTATIC SARCOMA

This study is for children, teens, and young adults up to age 39 with sarcoma that has spread to a few other places in the body. Researchers want to see if giving extra radiation to those spread spots, along with usual treatment, can help patients live longer without the cancer g…

This study tests a drug called avapritinib in people with advanced solid tumors that have spread and have specific gene changes (CKIT or PDGFRA mutations). The drug works by blocking enzymes that help cancer cells grow. The goal is to see if avapritinib can shrink or control thes…

This early-phase trial tests whether combining two drugs—peposertib and a low-dose form of the chemotherapy doxorubicin—is safe and effective for people with advanced sarcomas that have spread or can't be removed by surgery. About 30 adults with specific sarcoma types will receiv…

This study tests whether freezing bone tumors (cryoablation) before giving radiation therapy works better than radiation alone for reducing pain. About 40 adults with cancer that has spread to the bones will be enrolled. The goal is to see if the combination provides more complet…

This study tests a rice-sized device implanted into tumors that releases tiny amounts of 10 different drugs. The goal is to see which drugs kill tumor cells without affecting the whole body. It involves 20 people with sarcoma who are already scheduled for surgery. The device is r…

This study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to understand how these vessels work, which could help decide if a patient's tumor is likely to respond to certain trea…

This study tests a checklist tool that helps sarcoma patients plan for their future mobility needs, such as getting around the house or dressing. About 20 patients and their caregivers will use the tool and give feedback on how easy and helpful it is. The goal is to see if this t…