Experimental drug combo aims to shrink Hard-to-Treat sarcomas
NCT ID NCT05711615
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests a combination of two drugs—peposertib and a low-dose form of the chemotherapy doxorubicin—in people with advanced sarcomas that have spread or can't be removed by surgery. The goal is to find the safest dose and see if the combo can shrink tumors or slow the disease. About 30 participants with specific sarcoma types will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Peposertib and liposomal doxorubicin
What this could lead to
If it works, this could point toward a new treatment option for advanced sarcomas that are hard to treat.
What could go wrong
This is a very early phase 1 trial with only 30 people, so it may not show benefit or could have unexpected side effects. The combination has not been proven in humans yet.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
Contact
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Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITINGBaltimore, Maryland, 21287, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Los Angeles General Medical Center
RECRUITINGLos Angeles, California, 90033, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Cancer Institute Developmental Therapeutics Clinic
RECRUITINGBethesda, Maryland, 20892, United States
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Siteman Cancer Center-South County
RECRUITINGSt Louis, Missouri, 63129, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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UC Comprehensive Cancer Center at Silver Cross
RECRUITINGNew Lenox, Illinois, 60451, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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UCHealth University of Colorado Hospital
RECRUITINGAurora, Colorado, 80045, United States
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USC / Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
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UT MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Chicago Comprehensive Cancer Center
RECRUITINGChicago, Illinois, 60637, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Chicago Medicine-Orland Park
RECRUITINGOrland Park, Illinois, 60462, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITINGMiami, Florida, 33136, United States
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Contact Phone: •••-•••-••••
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University of Michigan Rogel Cancer Center
SUSPENDEDAnn Arbor, Michigan, 48109, United States
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University of Pittsburgh Cancer Institute (UPCI)
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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Contact Phone: •••-•••-••••
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University of Virginia Cancer Center
RECRUITINGCharlottesville, Virginia, 22908, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••