ANATOMIC STAGE IV BREAST CANCER AJCC V8
Clinical trials for ANATOMIC STAGE IV BREAST CANCER AJCC V8 explained in plain language.
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New drug combo shows promise for Hard-to-Treat breast cancer
Disease control CompletedThis phase 2 trial tests a new drug called TVB-2640 (denifanstat) combined with trastuzumab and either chemotherapy (paclitaxel) or hormone therapy in 17 people with HER2+ metastatic breast cancer that no longer responds to trastuzumab. TVB-2640 blocks an enzyme cancer cells need…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jul 02, 2026 02:00 UTC
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Zapping tumors with precision radiation may help control limited metastatic breast cancer
Disease control CompletedThis study looked at whether adding focused radiation (SBRT) or surgery to standard treatments like chemo or hormone therapy helps people with breast cancer that has spread to just one or two places. 129 participants were randomly assigned to get standard care alone or standard c…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2, PHASE3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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Experimental drug combo targets Hard-to-Treat cancers
Disease control CompletedThis early-phase trial tested a new drug called AZD8186 combined with the chemotherapy docetaxel in 23 patients with advanced solid tumors that have PTEN or PIK3CB gene mutations. The main goal was to find the safest dose and understand side effects. The study is complete, but re…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Personalized home workouts boost activity in advanced breast cancer
Symptom relief CompletedThis study tested a personalized home exercise program for women with metastatic breast cancer who were not very active. The program was designed by a cancer exercise specialist to fit each patient's needs and abilities. The goal was to see if it could help them become more physi…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: Thomas Jefferson University • Aim: Symptom relief
Last updated Jun 27, 2026 07:58 UTC
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Cancer moonshot study banks tissue to unlock genetic secrets
Knowledge-focused CompletedThis completed study collected blood and tumor tissue from 64 patients with advanced cancers (like melanoma, breast, lung, and kidney cancer) to study genetic changes and treatment resistance. The samples are stored for future research, including genomic analysis. No new treatmen…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Blood test may help Fine-Tune breast cancer medication levels
Knowledge-focused CompletedThis study looked at whether a blood test called DiviTum-TKa can help doctors check if patients with metastatic breast cancer are taking their CDK4/6 inhibitor medication correctly and if other drugs are interfering. The test measures a marker of cell growth to see if the treatme…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: Yale University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC