New drug combo shows promise for Hard-to-Treat breast cancer
NCT ID NCT03179904
First seen Jun 26, 2026 · Last updated Jul 02, 2026 · Updated 3 times
Summary
This phase 2 trial tests a new drug called TVB-2640 (denifanstat) combined with trastuzumab and either chemotherapy (paclitaxel) or hormone therapy in 17 people with HER2+ metastatic breast cancer that no longer responds to trastuzumab. TVB-2640 blocks an enzyme cancer cells need to grow, while trastuzumab targets HER2 receptors. The goal is to see if this combination can shrink tumors and control the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Denifanstat (TVB-2640), a FASN inhibitor, combined with trastuzumab and either paclitaxel or endocrine therapy
- What this could lead to
- If successful, this could offer a new treatment option for people with HER2+ metastatic breast cancer whose cancer has stopped responding to standard trastuzumab-based therapy.
- What could go wrong
- This is a small, early-phase trial with only 17 participants, so results may not apply to everyone. The combination may cause side effects or fail to shrink tumors in many patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Mayo Clinic in Arizona
Scottsdale, Arizona, 85259, United States
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Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a triple drug combo shrink HER2-Positive breast tumors before surgery?
- Fasting during chemo: a new way to boost treatment?
- Can an extra radiation dose keep HER2+ breast cancer at bay?
- Gut bacteria may fortify bones in breast cancer therapy
- Can a drug cocktail cure metastatic breast cancer? a trial aims to find out
- Can less chemo be enough? a trial challenges standard treatment for HER2-Positive breast cancer