ANATOMIC STAGE III BREAST CANCER AJCC V8
Clinical trials for ANATOMIC STAGE III BREAST CANCER AJCC V8 explained in plain language.
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New hope for tough breast cancer: trial tests pill to boost standard treatment
Disease control Recruiting nowThis early-stage trial is testing the safety and best dose of a new oral drug, ASTX727, when added to standard chemotherapy and immunotherapy for patients with metastatic triple-negative breast cancer. The study aims to see if this combination can shrink or control tumors better …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Scientists test novel drug duo in fight against Tough-to-Treat cancers
Disease control Recruiting nowThis early-phase study aims to find a safe and tolerable dose of a new drug combination for people with advanced breast cancer and other solid tumors that have a protein called HER2. The trial will test pidnarulex, which aims to stop tumor cell growth, together with an existing t…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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Vaccine joins fight against breast cancer in new trial
Disease control Recruiting nowThis study is testing whether adding an experimental vaccine called WOKVAC to standard pre-surgery treatment can help the immune system better fight HER2-positive breast cancer. The trial will enroll 25 adults with early-stage breast cancer to receive the vaccine along with their…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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Zapping tumors: wearable device tested with drugs for tough cancers
Disease control Recruiting nowThis early-stage trial is testing the safety of combining a wearable device that uses electric fields to disrupt cancer cells with different drug combinations. It is for adults with advanced cancers in the abdomen or chest that have spread and who have run out of standard treatme…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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New study tests which hormone blocker works best for younger breast cancer patients
Disease control Recruiting nowThis study compares two different hormone-blocking treatments (leuprolide and goserelin) for premenopausal women with breast cancer. Both drugs work by reducing estrogen production, which can help slow or stop cancer growth. Researchers will measure how well each treatment lowers…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Michigan Rogel Cancer Center • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Major trial uses genetic blueprint to find the right drug combo for advanced cancer
Disease control Recruiting nowThis trial is a large screening program that matches patients with advanced solid tumors to one of many smaller treatment studies. It uses genetic testing on a patient's tumor to find specific mutations. Patients are then assigned to a drug combination designed to target those mu…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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New hope for when standard breast cancer drugs stop working
Disease control Recruiting nowThis study is testing two new drug combinations for people with advanced, BRCA-positive breast cancer that has spread and has stopped responding to a standard type of targeted therapy (PARP inhibitors). The trial will see if adding a second drug to the standard one can shrink tum…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Personalized weight loss plans aim to boost survival for latina breast cancer survivors
Disease control Recruiting nowThis study is testing different remote weight loss programs designed specifically for Latina women who have survived early-stage breast cancer. Researchers want to see if personalized, community-focused support can help participants lose weight and improve their long-term health.…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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First human trial tests new drug duo against aggressive cancers
Disease control Recruiting nowThis early-stage study aims to find the safest dose of two oral drugs—ZEN003694 and abemaciclib—when given together to patients with advanced cancers that have spread or cannot be removed by surgery. The trial will enroll about 45 adults and teens (12+) with specific cancers, inc…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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New trial tests if switching PARP inhibitors can help control advanced cancers
Disease control Recruiting nowThis study is testing whether the drug talazoparib can help control advanced cancers in patients whose tumors have specific mutations in genes that help repair DNA damage. It is enrolling 36 adults with various advanced solid tumors (like breast, ovarian, prostate, pancreatic, an…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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Scientists test 'One-Two Punch' against Tough-to-Treat cancers
Disease control Recruiting nowThis early-stage study is testing the safety and best dose of a new two-drug combination for people with advanced solid tumors that have a specific marker called HER2. The treatment pairs an existing targeted cancer drug with a new pill that aims to block cancer cells' ability to…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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New hope for Tough-to-Treat breast cancer: old drugs, new combo
Disease control Recruiting nowThis study is testing whether combining two existing drugs—tamoxifen and a special form of doxorubicin—can help control advanced triple-negative breast cancer that has spread or cannot be removed by surgery. It is for patients whose cancer has continued to grow despite at least t…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Mar 27, 2026 12:38 UTC
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Doctors test custom cancer vaccine to train immune system
Disease control Recruiting nowThis early-stage trial is testing a new, personalized vaccine for triple-negative breast cancer (TNBC). The vaccine is custom-made from a piece of a patient's own tumor and is designed to teach their immune system to recognize and attack the cancer. Researchers are studying the v…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: Emory University • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Major trial aims to stop High-Risk breast cancer from coming back
Disease control Recruiting nowThis large, late-stage trial is testing if adding an immunotherapy drug called durvalumab to standard chemotherapy is better than chemotherapy alone for preventing cancer from returning. It is for adults with a specific high-risk type of breast cancer that is hormone-positive and…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Scientists test Triple-Threat attack on tough breast cancer
Disease control Recruiting nowThis early-stage trial is testing the safety of a new three-drug combination for people with advanced triple-negative breast cancer. It combines a new experimental pill (ZEN003694) with an immunotherapy drug (pembrolizumab) and a standard chemotherapy (nab-paclitaxel). The main g…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Could skipping extra treatment keep cancer away just as well?
Disease control Recruiting nowThis large study is for people with early-stage triple-negative breast cancer who had no detectable cancer left after their initial chemo-immunotherapy and surgery. It aims to find out if simply watching closely (observation) works just as well at preventing the cancer from comin…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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5 days instead of weeks: new hope for faster breast cancer treatment
Disease control Recruiting nowThis study is testing a much shorter radiation schedule for people with early-stage breast cancer. Instead of treatments over several weeks, participants receive radiation to the whole breast and the surgical area at the same time, completed in just 5 daily sessions. The main goa…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Mar 24, 2026 12:02 UTC
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Faster radiation for breast cancer: can timing cut side effects?
Disease control Recruiting nowThis study is testing whether giving a shorter, more intense course of radiation therapy *before* breast cancer surgery is as safe and effective as giving it *after* surgery. It aims to see if the pre-surgery timing can reduce side effects and treatment time for 120 patients with…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 24, 2026 12:02 UTC
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Custom-Made vaccine aims to train immune system to fight advanced cancers
Disease control Recruiting nowThis study is testing a new, personalized vaccine designed to target the unique proteins on a patient's own cancer cells. It is being given alongside an existing immunotherapy drug (pembrolizumab) to see if the combination is safe and can help control advanced solid tumors that h…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 20, 2026 14:48 UTC
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Gentler chemo trial aims to spare older women harsh side effects
Disease control Recruiting nowThis study is testing whether a lower dose of a common chemotherapy combination (docetaxel and cyclophosphamide) works as well as the standard dose for women aged 65 and older with early-stage breast cancer. The main goal is to see if the reduced dose is easier to tolerate, cause…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Mar 12, 2026 13:50 UTC
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New ultrasound could tell doctors if chemo is working sooner
Diagnosis Recruiting nowThis study is testing a new type of ultrasound imaging to see if it can predict how well chemotherapy will work for patients with locally advanced breast cancer. Researchers will use a special contrast dye during ultrasounds to measure pressure inside the tumor before and during …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2, PHASE3 • Sponsor: Kibo Nam • Aim: Diagnosis
Last updated Mar 30, 2026 14:28 UTC
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Mayo clinic tests 'Twinkling' marker to improve breast cancer node detection
Diagnosis Recruiting nowThis early-stage study is testing a new type of biopsy marker designed to be easier for surgeons to see on ultrasound scans during breast cancer operations. The marker is placed in a cancerous lymph node before treatment and is meant to help guide surgeons to the correct node for…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Mar 02, 2026 15:21 UTC
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Common diabetes drug may shield breast cancer survivors from new health threat
Prevention Recruiting nowThis study is testing whether adding the diabetes medication metformin to standard healthy lifestyle advice can better prevent or reverse insulin resistance in women who have finished chemotherapy for early-stage breast cancer. Researchers want to see if metformin helps normalize…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: City of Hope Medical Center • Aim: Prevention
Last updated Mar 25, 2026 14:09 UTC
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New surgical technique aims to stop debilitating arm swelling before it starts
Prevention Recruiting nowThis study is testing whether performing a special surgical connection, called a lymphovenous bypass, at the same time as standard underarm lymph node removal can prevent a painful and chronic side effect called lymphedema (arm swelling). The research involves 252 adults with adv…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Prevention
Last updated Mar 24, 2026 12:01 UTC
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Can a 'Brain Food' diet fight chemotherapy fog?
Symptom relief Recruiting nowThis study is testing whether following a specific healthy eating plan called the MIND diet can help reduce thinking and memory problems (often called 'chemobrain'), fatigue, and other symptoms in women undergoing chemotherapy for triple-negative breast cancer. Researchers will c…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief
Last updated Apr 01, 2026 14:41 UTC
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New hope for hair loss in breast cancer patients
Symptom relief Recruiting nowThis early study is testing whether a pill or a foam version of the hair growth drug minoxidil works better to treat hair loss caused by hormone therapy in breast cancer patients. It will involve about 50 women with stage I-IV breast cancer who are experiencing this side effect. …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: EARLY_PHASE1 • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief
Last updated Mar 30, 2026 14:33 UTC
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Beauty boost for breast cancer survivors: study tests if skincare eases medication side effects
Symptom relief Recruiting nowThis study aims to see if skincare consultations can improve skin appearance and quality of life for breast cancer survivors who are starting aromatase inhibitor therapy. Researchers will enroll 25 postmenopausal women with early-stage breast cancer to track skin changes using sp…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Mar 23, 2026 15:19 UTC
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Can a 10-Week program ease the burden for breast cancer patients?
Symptom relief Recruiting nowThis study is testing whether a 10-week stress reduction and support program is practical and helpful for patients with triple-negative breast cancer. The program teaches relaxation, coping skills, and problem-solving, while also connecting participants with social workers to hel…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief
Last updated Mar 23, 2026 15:17 UTC
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New program aims to help older breast cancer survivors reclaim their health
Symptom relief Recruiting nowThis study tests a specialized geriatric care program designed to help older adults who have finished curative treatment for early-stage breast cancer. The program involves comprehensive health assessments, personalized follow-up visits, and activity tracking to address physical,…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Mar 23, 2026 15:15 UTC
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Can ancient yoga and modern education ease Survivors' struggle?
Symptom relief Recruiting nowThis study is testing whether two different wellness programs are practical and acceptable for breast cancer survivors who have finished their main treatment but still have a low quality of life. About 108 survivors will try either a multi-part program with yoga, nutrition advice…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: University of California, San Francisco • Aim: Symptom relief
Last updated Mar 17, 2026 13:09 UTC
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Needles vs. pressure: new hope for black women battling breast cancer drug pain
Symptom relief Recruiting nowThis study is testing whether acupuncture or virtual acupressure can prevent severe joint pain caused by a common breast cancer medication. It focuses on Non-Hispanic Black postmenopausal women with early-stage breast cancer, as they are more likely to experience this side effect…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: Emory University • Aim: Symptom relief
Last updated Mar 11, 2026 14:53 UTC
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Tracking friendships and fitness after cancer: how relationships shape recovery
Knowledge-focused Recruiting nowThis study aims to understand how personal relationships and physical activity affect the well-being of young adults who have survived cancer. Researchers will follow 250 young adult survivors for one year, having them complete surveys and wear activity trackers. The goal is to l…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: University of Southern California • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:41 UTC
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New scan could tell doctors which breast cancer drugs will work
Knowledge-focused Recruiting nowThis study is testing whether a special type of PET scan can predict if a breast cancer drug called abemaciclib will work for patients with advanced hormone-positive, HER2-negative breast cancer. Researchers will give 60 participants this special scan before and after a brief hor…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:35 UTC
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New tool aims to guide women through tough breast cancer surgery decisions
Knowledge-focused Recruiting nowThis study is testing a new online tool designed to help women with early-stage breast cancer make informed decisions about surgery. The tool provides clear information about the risks of cancer in the other breast and the potential benefits of removing it preventively. Patients …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:32 UTC
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Scientists track Body's hidden battle against breast cancer during treatment
Knowledge-focused Recruiting nowThis study aims to understand how the immune system reacts during standard treatments for HER2-positive breast cancer. Researchers will collect blood and tissue samples from 230 patients with stage I-IV breast cancer who are receiving or have received anti-HER2 drugs like trastuz…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:38 UTC
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Scientists gather clues from survivors to unlock breast Cancer's Long-Term secrets
Knowledge-focused Recruiting nowThis study is creating a large collection of blood samples and health information from people who have survived early-stage breast cancer. The goal is to build a resource for future scientists to study how factors like genetics, lifestyle, and environment affect long-term health …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: University of Southern California • Aim: Knowledge-focused
Last updated Mar 24, 2026 12:03 UTC
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Gene test could predict which breast cancers resist common drug
Knowledge-focused Recruiting nowThis study aims to understand if a specific gene mutation (HSD3B1) makes the breast cancer drug letrozole less effective. Postmenopausal women with early-stage, hormone-sensitive breast cancer will take letrozole for a few weeks before their standard surgery. Researchers will com…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE4 • Sponsor: University of Washington • Aim: Knowledge-focused
Last updated Mar 24, 2026 12:02 UTC
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Scientists track sleep patterns in breast cancer patients to uncover hidden health links
Knowledge-focused Recruiting nowThis study aims to understand how breast cancer treatment affects sleep patterns and quality. Researchers will follow 100 patients with early-stage breast cancer, having them wear sleep trackers and complete surveys from treatment through recovery. The goal is to identify factors…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:17 UTC
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Scientists build a living library of cancer to unlock treatment secrets
Knowledge-focused Recruiting nowThis study is collecting tissue and blood samples from cancer patients over time to create a research resource called a biobank. Researchers will analyze these samples to understand how cancer changes during treatment and why some treatments stop working. The goal is to help scie…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Mar 17, 2026 13:09 UTC