ANATOMIC STAGE III BREAST CANCER AJCC V8
Clinical trials for ANATOMIC STAGE III BREAST CANCER AJCC V8 explained in plain language.
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New hope for slowing advanced breast cancer
Disease control OngoingThis large, late-stage trial is testing whether adding a new drug called entinostat to standard hormone therapy (exemestane) works better than the hormone therapy alone. It's for people whose hormone-sensitive, advanced breast cancer has continued to grow despite prior treatment.…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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New combo attack on advanced breast cancer
Disease control OngoingThis study is testing whether adding an immunotherapy drug (atezolizumab) to a targeted cancer drug (olaparib) works better than the targeted drug alone for people with advanced breast cancer that has a specific genetic flaw (BRCA mutation). The goal is to see if the combination …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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New drug combo tested for Tough-to-Treat advanced cancers
Disease control OngoingThis early-stage study is testing a new combination of two drugs, AZD8186 and docetaxel, for patients with advanced solid tumors that have specific genetic changes (PTEN or PIK3CB mutations). The main goals are to find the safest and most effective dose and to understand the side…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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Can a text message save a life? new study aims to keep breast cancer patients on track
Disease control OngoingThis study is testing whether simple support tools can help breast cancer patients remember to take their daily hormone therapy pills correctly. Researchers are comparing text message reminders, phone-based counseling sessions, or both, against standard care to see which method w…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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Estrogen tested as surprising weapon against aggressive breast cancer
Disease control OngoingThis study is testing whether estradiol, a form of estrogen, can help control advanced triple-negative breast cancer that has a specific biomarker called ER beta. Researchers are giving estradiol pills to 8 postmenopausal women whose cancer has spread and seeing if their tumors s…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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Faster radiation treatment tested for breast cancer patients
Disease control OngoingThis study compares two radiation treatments given after breast cancer surgery. It tests whether a newer, shorter proton beam treatment (5 sessions) causes fewer complications than standard x-ray therapy (25 sessions). The trial involves 146 women with early to mid-stage breast c…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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Scientists test new weapon to attack advanced cancers
Disease control OngoingThis early-stage trial is testing a new drug called BAY 1895344, given alongside standard chemotherapy drugs, in people with advanced solid tumors that have spread. The main goal is to find the safest and most effective dose of this combination. Researchers are especially interes…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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New combo therapy trial offers hope for HIV patients with advanced cancers
Disease control OngoingThis is a small, early-stage safety study testing a combination of two cancer drugs, nivolumab and cabozantinib, in people living with HIV who have advanced solid tumors. The main goal is to see if the two-drug combination is safe and tolerable for this specific patient group. Re…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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New hope for Tough-to-Treat breast cancer
Disease control OngoingThis study is testing whether adding a new experimental drug, TVB-2640, to standard treatments can help control advanced HER2-positive breast cancer that has spread and is no longer responding to the usual therapies. It involves a small group of patients whose cancer has progress…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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New vaccine trial aims to train body to destroy breast cancer cells
Disease control OngoingThis study is testing an experimental vaccine called STEMVAC in people with early-stage triple-negative breast cancer who have already finished their standard treatments. The goal is to see if the vaccine can safely 'wake up' the immune system to recognize and attack specific pro…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated Mar 23, 2026 15:29 UTC
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Doctors use genetic blueprint to fight advanced cancers
Disease control OngoingThis study is testing a personalized treatment method for people with advanced breast, prostate, ovarian, pancreatic, or sarcoma cancers that have spread. Doctors analyze each patient's tumor using genetic and protein tests to understand how the cancer is changing and which drugs…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: OHSU Knight Cancer Institute • Aim: Disease control
Last updated Mar 23, 2026 15:18 UTC
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Double attack on tough cancers: early trial tests combo for patients out of options
Disease control OngoingThis early-stage trial is testing a combination of two drugs, niraparib and dostarlimab, for people with advanced breast, ovarian, pancreatic, or related cancers that have a specific genetic change (BRCA mutation) and have stopped responding to standard treatments. The goal is to…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: University of Washington • Aim: Disease control
Last updated Mar 23, 2026 15:16 UTC
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Scientists test new Triple-Threat attack on tough cancers
Disease control OngoingThis early-stage study is testing the safety and best dose of a three-drug combination (entinostat, nivolumab, and ipilimumab) for people with advanced solid tumors that have spread and are hard to treat. The goal is to see if boosting the immune system with two drugs while using…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 23, 2026 15:16 UTC
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New hope for High-Risk breast cancer patients: can two drugs beat one?
Disease control OngoingThis large study is testing whether adding the drug tucatinib to standard treatment (T-DM1) works better at preventing breast cancer from coming back. It is for people with a specific type of high-risk, HER2-positive breast cancer who still have some cancer cells after their init…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Mar 18, 2026 14:42 UTC
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Early trial aims to tame tough cancers with Two-Pronged attack
Disease control OngoingThis early-stage study is testing a new drug, ALRN-6924, combined with a standard chemotherapy (paclitaxel) for people with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find the safest and most effective dose of this combination an…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 13, 2026 15:06 UTC
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New drug duo aims to slow aggressive breast cancer
Disease control OngoingThis study is testing if combining two drugs, copanlisib and eribulin, is safe and more effective at controlling advanced triple-negative breast cancer than standard eribulin chemotherapy alone. It involves about 24 patients whose cancer has spread and who have already tried othe…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 05, 2026 13:59 UTC
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New 'Twinkling' marker could make breast cancer surgery more precise
Diagnosis TerminatedThis early-stage study is testing a new type of marker designed to help surgeons locate cancerous lymph nodes more easily during breast cancer surgery. The marker is placed in the lymph node before treatment and surgery. Researchers want to see if it stays visible on ultrasound a…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Apr 01, 2026 14:42 UTC
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New scan could tell doctors if breast cancer treatment is working sooner
Diagnosis OngoingThis study is testing a special imaging scan (FDG-PET/CT) to see if it can predict how well standard chemotherapy works for patients with HER2-positive breast cancer before they have surgery. The scan is done early in treatment to measure changes in the cancer's activity. If succ…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Diagnosis
Last updated Mar 30, 2026 14:34 UTC
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Virtual support aims to calm cancer fears
Symptom relief TerminatedThis study aimed to test an online mental health program designed to help women with advanced breast or gynecologic cancers manage their fear of the cancer coming back or getting worse. Participants would have been randomly assigned to either the main program, which taught coping…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: City of Hope Medical Center • Aim: Symptom relief
Last updated Apr 01, 2026 14:43 UTC
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Digital kitchen program aims to nourish breast cancer survivors
Symptom relief OngoingThis study is testing whether a 6-week online program that teaches mindful cooking and nutrition can help breast cancer survivors eat healthier. About 50 participants who have finished treatment for early-stage breast cancer will try the program or receive standard care. Research…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: Fred Hutchinson Cancer Center • Aim: Symptom relief
Last updated Mar 30, 2026 14:32 UTC
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New web portal aims to empower young women after breast cancer
Symptom relief OngoingThis study is testing a website called YES, designed to help young women who have finished breast cancer treatment. The goal is to see if using this website to track and manage symptoms improves their quality of life better than standard follow-up care. About 400 young survivors …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief
Last updated Mar 18, 2026 14:41 UTC
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Texting for better sleep: can a chatbot ease insomnia after breast cancer?
Symptom relief OngoingThis study is testing a text-message chatbot named Cecebot, designed to help breast cancer survivors who have trouble sleeping. The chatbot provides sleep coaching and gentle activity suggestions based on proven therapies. Researchers want to see if using the chatbot for 6 weeks …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: University of Washington • Aim: Symptom relief
Last updated Mar 17, 2026 13:09 UTC
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Can writing heal? study tests Pen-and-Paper therapy for breast cancer survivors
Symptom relief OngoingThis study is testing whether a brief writing program, designed specifically for Chinese immigrant culture, can help improve the quality of life and reduce stress for women who have survived breast cancer. Researchers are comparing three different types of writing exercises to se…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Mar 17, 2026 13:08 UTC
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Can walking and strength training ease chemo side effects for seniors?
Symptom relief OngoingThis study is testing whether a home-based exercise program is practical and helpful for women aged 65 and older who are receiving chemotherapy for early-stage breast cancer. Participants follow a walking and strength training plan during their treatment. The main goal is to see …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Mar 12, 2026 13:52 UTC
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Can we predict who gets nerve damage from chemo?
Knowledge-focused OngoingThis study aims to create a tool to predict which cancer patients are most likely to develop nerve damage (like tingling or numbness in hands and feet) from a common class of chemotherapy drugs called taxanes. Researchers will follow over 1,300 patients with breast, lung, or ovar…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: SWOG Cancer Research Network • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:12 UTC
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New tool aims to guide tough chemo choices for senior breast cancer patients
Knowledge-focused OngoingThis study aims to understand the information needs of women aged 65 and older with early-stage breast cancer who are deciding whether to have chemotherapy before or after surgery. Researchers are interviewing patients and doctors to develop a tailored decision support tool. The …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:30 UTC
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Can a simple test predict painful chemo side effects?
Knowledge-focused OngoingThis study aims to validate a genetic test that might predict which African American women with early-stage breast cancer are at higher risk for nerve damage (neuropathy) from common chemotherapy drugs. It also compares two different chemotherapy schedules to see which one might …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:28 UTC
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Blood test aims to predict breast Cancer's return
Knowledge-focused TerminatedThis study is testing a blood test that looks for tiny pieces of leftover cancer DNA after treatment for early-stage breast cancer. The goal is to see if this test can identify patients who still have hidden cancer cells and might benefit from additional therapy. Researchers will…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: City of Hope Medical Center • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:15 UTC
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Genetic testing trial aims to match breast cancer patients with right treatments
Knowledge-focused OngoingThis study is testing whether analyzing the genetic makeup of breast tumors can help predict which standard treatments will work best for individual patients. Researchers are enrolling 1,100 people with early-stage breast cancer to see if genetic testing can accurately identify t…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Mar 19, 2026 14:56 UTC
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Cancer survivors share their fertility struggles in major survey
Knowledge-focused OngoingThis study is a survey designed to understand the experiences of women who have survived breast or gynecological cancers when it comes to family planning and fertility. Researchers are asking over 1,400 survivors about their decisions, challenges, and use of fertility services af…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Mar 02, 2026 15:22 UTC