ANATOMIC STAGE III BREAST CANCER AJCC V8
Clinical trials for ANATOMIC STAGE III BREAST CANCER AJCC V8 explained in plain language.
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Could a vaccine keep triple negative breast cancer from returning?
⭐️ VACCINE ⭐️ OngoingThis phase II trial tests a DNA-based vaccine called STEMVAC in 33 people with early-stage triple negative breast cancer (stages IB-III). The vaccine is designed to train the immune system to recognize and attack cancer cells that express certain proteins. Participants also recei…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: ⭐️ VACCINE ⭐️
Last updated Jun 27, 2026 12:29 UTC
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New drug cocktail targets Hard-to-Treat breast cancer in early trial
Disease control TerminatedThis phase I trial is testing a new drug called ASTX727 (a combination of decitabine and cedazuridine) alongside standard chemotherapy (paclitaxel) and immunotherapy (pembrolizumab) for people with metastatic triple-negative breast cancer that cannot be removed by surgery. The st…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Experimental combo targets Hard-to-Treat HER2 cancers
Disease control OngoingThis early-phase trial is testing a combination of two drugs—trastuzumab deruxtecan (a targeted chemotherapy) and ceralasertib (a drug that may block cancer cell repair)—in people with advanced solid tumors that have a HER2 mutation. The study has two parts: first, finding the sa…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New combo aims to stop HER2+ breast cancer relapse
Disease control OngoingThis phase III trial tests whether adding tucatinib to standard T-DM1 therapy works better than T-DM1 alone at preventing breast cancer from coming back. It involves over 1,000 patients with HER2-positive breast cancer who still have cancer cells after initial treatment. The stud…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New drug cocktail shows promise against tough breast cancer
Disease control OngoingThis study tests a combination of two drugs, eribulin and copanlisib, in people with metastatic triple-negative breast cancer that has spread or cannot be removed. The goal is to find the safest dose and see if the combo can slow tumor growth better than eribulin alone. About 24 …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Experimental drug combo targets Hard-to-Treat cancers
Disease control OngoingThis early-phase trial tests an experimental drug called BAY 1895344 combined with standard chemotherapy (cisplatin, with or without gemcitabine) in people with advanced solid tumors, especially urothelial cancer. The goal is to find the best dose and see how safe the combination…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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Could a drug combo slow advanced breast cancer?
Disease control OngoingThis phase 3 trial tests whether adding entinostat to the hormone therapy exemestane helps control advanced hormone receptor-positive breast cancer better than exemestane alone. About 600 patients with locally advanced or metastatic breast cancer are participating. The study meas…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New combo therapy tackles cancer in HIV patients
Disease control OngoingThis early-phase trial tests the safety of combining two cancer drugs, nivolumab and cabozantinib, in people with HIV who have advanced solid tumors. Only 8 participants were enrolled. The goal is to see if the combination is safe and can shrink or stabilize tumors.
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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New combo targets tough breast cancer: could it be a game changer?
Disease control OngoingThis phase II trial tests whether adding an immunotherapy drug (atezolizumab) to a targeted therapy (olaparib) works better than olaparib alone for advanced non-HER2-positive breast cancer that has a BRCA mutation. About 81 patients with locally advanced or metastatic disease are…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New targeted therapy combo shows promise for HER2+ breast cancer
Disease control OngoingThis study tests a combination of targeted drugs (ribociclib, tucatinib, trastuzumab, with or without fulvestrant) for HER2-positive breast cancer. In the first part, it looks at safety in patients whose cancer has spread. In the second part, it compares these drugs to standard c…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Could estrogen shrink some triple negative breast tumors?
Disease control OngoingThis phase II trial at Mayo Clinic tests whether estradiol, a form of estrogen, can help patients with a specific subtype of triple negative breast cancer that has a receptor called ER beta. The study enrolls 8 women with advanced or metastatic disease. Researchers will measure h…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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Can a digital kitchen program help breast cancer survivors eat healthier?
Disease control OngoingThis pilot study tests a remotely-delivered nutrition and cooking program called MIND for stage I-III breast cancer survivors. The program is delivered online through the Cook for Your Life platform and aims to improve diet quality. The study will enroll 49 participants to see if…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New drug cocktail shows promise in early cancer trial
Disease control OngoingThis phase 1 trial is testing the safety and best dose of a combination of three drugs—entinostat, nivolumab, and ipilimumab—in people with advanced solid tumors that have spread or cannot be removed. The goal is to see if this mix can help the immune system fight cancer more eff…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Proton vs X-Ray: which radiation causes fewer side effects in breast cancer?
Disease control OngoingThis study compares two types of radiation therapy—standard x-ray and proton beam—for people with breast cancer who have had surgery. The goal is to see which method causes fewer serious side effects or unplanned surgeries over two years. About 146 adults with stage I to III brea…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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New drug combo targets BRCA cancers in early trial
Disease control OngoingThis early-phase study tests a combination of two drugs, niraparib and dostarlimab, in 18 adults with BRCA-mutated breast, pancreas, or ovary cancer that has spread or cannot be surgically removed. Niraparib blocks a DNA repair protein in cancer cells, while dostarlimab helps the…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: University of Washington • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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PET scans may guide breast cancer treatment before surgery
Diagnosis OngoingThis phase 2 trial tests whether a special PET/CT scan using a radioactive tracer (FDG) can predict how well HER2-positive breast cancer responds to standard chemotherapy before surgery. About 235 patients with stage II-III HER2+ breast cancer will get the scan early in treatment…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Diagnosis
Last updated Jun 27, 2026 14:00 UTC
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New ultrasound technique may predict chemo success early in breast cancer
Diagnosis OngoingThis study tests whether a special type of ultrasound, using a contrast dye called Definity, can measure pressure inside breast tumors to predict how well chemotherapy is working. About 200 women with locally advanced breast cancer will get three of these ultrasounds before and d…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2, PHASE3 • Sponsor: Kibo Nam • Aim: Diagnosis
Last updated Jun 27, 2026 14:00 UTC
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New program aims to boost health in older breast cancer survivors
Symptom relief OngoingThis study tests a geriatric care survivorship program for adults aged 65 and older who have finished curative treatment for early-stage breast cancer. The program includes a full health assessment, education, activity tracking, and supportive care. Researchers hope this approach…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Texting symptoms may keep young breast cancer patients on treatment
Symptom relief OngoingThis study tests whether regular symptom check-ins via text or email, plus educational materials, can help young women with early-stage breast cancer stay on their hormone therapy. Many women stop treatment early due to side effects. The trial involves 565 women and compares symp…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: SWOG Cancer Research Network • Aim: Symptom relief
Last updated Jun 27, 2026 12:03 UTC
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Walking through chemo: new study tests exercise for older breast cancer patients
Symptom relief OngoingThis study looks at whether a regular exercise program is practical for women aged 65 and older who are receiving chemotherapy for early-stage breast cancer. Participants will be asked to walk and do arm exercises several times a week. The goal is to see if exercise can reduce th…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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New web tool aims to ease symptoms for young breast cancer survivors
Symptom relief OngoingThis study tests a web-based portal called YES (Young, Empowered & Strong) designed to help adolescent and young adult breast cancer survivors monitor and manage their symptoms. Researchers will compare the quality of life of 400 women who use the portal to those receiving standa…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 09:06 UTC
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Writing away the pain: new study tests expressive writing for chinese breast cancer survivors
Symptom relief OngoingThis study looks at whether a culturally tailored writing program can improve the well-being of Chinese immigrant women who had breast cancer (stages 0 to III). About 256 women who finished their main cancer treatment in the last 5 years will write about their experiences. The go…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Texts and talks: a new way to boost breast cancer Pill-Taking
Symptom relief OngoingThis study tests whether text message reminders and phone counseling help women with early-stage breast cancer take their daily hormone therapy pills as prescribed. About 1,167 women will be split into groups: some get usual care, others get texts and/or motivational interviewing…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Symptom relief
Last updated Jun 26, 2026 15:07 UTC
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Wheat germ supplement studied for immune boost in advanced cancer
Knowledge-focused TerminatedThis study looks at whether a fermented wheat germ supplement can help the immune system fight cancer better when taken with standard immunotherapy drugs. About 100 adults with advanced solid tumors (like lung, colon, or melanoma) will take the supplement alongside their usual tr…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: University of California, Davis • Aim: Knowledge-focused
Last updated Jul 02, 2026 06:00 UTC
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Blood test could spot hidden cancer cells after breast cancer surgery
Knowledge-focused TerminatedThis study was designed to see if a blood test that looks for tiny pieces of tumor DNA (called ctDNA) could find leftover cancer cells in people with early-stage breast cancer after standard treatment. The goal was to help doctors decide who might need more therapy. However, the …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: City of Hope Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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Can we predict who will get nerve damage from chemo?
Knowledge-focused OngoingThis study aims to find out why some cancer patients develop nerve damage (tingling or numbness in hands and feet) from taxane chemotherapy. Researchers will track over 1,300 people with breast, lung, or ovarian cancer to see how age, gender, and other factors affect their risk. …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: SWOG Cancer Research Network • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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Genetic test may predict who gets nerve pain from breast cancer chemo
Knowledge-focused OngoingThis study looks at whether certain genes make African American women with breast cancer more likely to develop nerve damage (pain, numbness, tingling) from common chemotherapy drugs called taxanes. About 249 women with stage I-III breast cancer will receive either docetaxel or w…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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Massive biobank aims to unlock Cancer's secrets
Knowledge-focused OngoingThis study collects tissue and blood samples from 1,600 people with various advanced cancers, along with their medical information, over the course of their treatment. Researchers will store these samples and data in a biobank for current and future studies. The goal is to better…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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New study aims to help older breast cancer patients make chemotherapy choices
Knowledge-focused OngoingThis study looks at how women aged 65 and older with early-stage breast cancer decide whether to have chemotherapy before or after surgery. Researchers will use surveys to understand their needs and then create a tool to help patients and doctors make better, shared decisions. Th…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Can ancient ayurveda help cancer survivors? new study tests feasibility
Knowledge-focused OngoingThis study looks at whether two different health programs are practical and acceptable for women who have finished treatment for early-stage breast cancer. One program combines nutrition advice, lifestyle changes, yoga, and therapeutic touch (Ayurveda). The other is a self-guided…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: University of California, San Francisco • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Study explores fertility hopes after cancer in young women
Knowledge-focused OngoingThis study surveys women aged 18-45 diagnosed with gynecological or breast cancer to understand how they think about having children after treatment. Researchers aim to gather insights that could help future patients and survivors make informed choices about cancer treatment and …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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New ultrasound marker could help surgeons find cancer in lymph nodes
Knowledge-focused TerminatedThis early-stage study tests a new type of marker that can be seen more clearly on ultrasound. It is placed in lymph nodes where breast cancer has spread. The goal is to see if the marker is safe, stays in place, and helps surgeons find the cancer during surgery. About 15 people …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Can smarter radiation save shoulders? new study investigates
Knowledge-focused OngoingThis study follows 61 women with lymph-node positive breast cancer to see how two types of radiation therapy affect shoulder and arm function one year after treatment. Participants receive either intensity-modulated radiation therapy (IMRT) or 3D conformal radiation therapy (3DCR…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Gene test may guide breast cancer therapy choices
Knowledge-focused OngoingThis study looks at whether a genetic test on tumor samples can predict how well HER2-negative breast cancer will respond to standard treatments like chemotherapy or hormone therapy. About 1,100 people with stage I-III breast cancer are taking part. The goal is to see if this tes…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Virtual therapy trial for cancer fear pulled before starting
Knowledge-focused TerminatedThis trial was designed to test whether an online mental health program could help women with advanced gynecologic or breast cancer manage their fear of the cancer returning or getting worse. The study planned to compare the online program to standard educational materials. Howev…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: City of Hope Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC