New drug cocktail targets Hard-to-Treat breast cancer in early trial
NCT ID NCT05673200
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase I trial is testing a new drug called ASTX727 (a combination of decitabine and cedazuridine) alongside standard chemotherapy (paclitaxel) and immunotherapy (pembrolizumab) for people with metastatic triple-negative breast cancer that cannot be removed by surgery. The study aims to find the safest dose and check for side effects. It includes 32 adults whose cancer has spread and who have not responded to other treatments. The trial is currently suspended.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ASTX727 (decitabine and cedazuridine) plus paclitaxel and pembrolizumab
What this could lead to
If it works, this could lead to a new combination treatment that helps shrink or stabilize metastatic triple-negative breast cancer for longer than current standard care.
What could go wrong
This is a very early phase I trial with only 32 participants, so the main goal is safety and dosing—not yet proof of effectiveness. The study is currently suspended, and side effects from combining these drugs could be significant.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic Hospital in Arizona
Phoenix, Arizona, 85054, United States
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Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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UC Irvine Health Cancer Center-Newport
Costa Mesa, California, 92627, United States
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UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, 92868, United States
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University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
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University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, 15232, United States
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VCU Massey Comprehensive Cancer Center
Richmond, Virginia, 23298, United States