ANATOMIC STAGE III BREAST CANCER AJCC V8

This phase 2 trial tests a new drug called TVB-2640 (denifanstat) combined with trastuzumab and either chemotherapy (paclitaxel) or hormone therapy in 17 people with HER2+ metastatic breast cancer that no longer responds to trastuzumab. TVB-2640 blocks an enzyme cancer cells need…

This early-phase trial tested a new drug called AZD8186 combined with the chemotherapy docetaxel in 23 patients with advanced solid tumors that have PTEN or PIK3CB gene mutations. The main goal was to find the safest dose and understand side effects. The study is complete, but re…

This early-phase trial tested a new drug called ALRN-6924 combined with the chemotherapy paclitaxel in 28 adults with advanced solid tumors that had spread or couldn't be removed by surgery, including a type of breast cancer. The main goal was to find the safest dose and check fo…

This study tested a text-message chatbot called Cecebot that combines sleep therapy and activity tips to help breast cancer survivors with insomnia. 60 women with stage I-III breast cancer and poor sleep used the chatbot for 6 weeks. The goal was to see if it was easy to stick wi…

This study tested whether an online program combining nutrition counseling and resistance training could improve physical function in older adults (65+) who finished treatment for breast, colorectal, or prostate cancer. 75 participants received virtual sessions with dietitians an…

This study tested a special pain program for breast cancer survivors who have joint and muscle pain from taking aromatase inhibitors (hormone therapy). The program combined education, coping skills, and gentle movement to help reduce pain, improve mood, and make it easier to stic…

This completed study collected blood and tumor tissue from 64 patients with advanced cancers (like melanoma, breast, lung, and kidney cancer) to study genetic changes and treatment resistance. The samples are stored for future research, including genomic analysis. No new treatmen…

This pilot study tested whether a stress test combined with a heart MRI can detect early signs of heart damage in premenopausal women treated for breast cancer. The study involved 25 women who had already received treatments like chemotherapy or hormone therapy. Researchers used …

This completed trial tested an interactive survivorship program for adolescent and young adult cancer survivors. The program included a mobile app, telehealth support, and printed materials to help survivors access healthcare resources, improve self-management skills, and reduce …

This study collected information and samples from 105 breast cancer survivors and healthy volunteers to create a research database. The goal is to help doctors better diagnose cancer, predict long-term health, and develop future treatments. Participants provided blood, urine, and…

This study looked at how the way blood samples are collected and processed affects the ability to detect tumor DNA in women with early-stage breast cancer. Researchers tested different collection tubes, processing speeds, and storage conditions to see which methods preserve tumor…