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Could radiation before surgery be better for breast cancer?

NCT ID NCT06635980

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial is testing whether giving a shorter, stronger course of radiation before breast surgery is safer and works better than giving it after surgery for people with non-metastatic breast cancer. The study will enroll 120 participants with different breast cancer types. The goal is to see if this approach reduces side effects and improves outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
hypofractionated radiation therapy
What this could lead to
If successful, this could show that giving radiation before surgery is safer and more effective than after, potentially reducing treatment time and side effects for breast cancer patients.
What could go wrong
This is a small, early-phase trial with only 120 participants, so results may not apply to all patients. There is still a risk of radiation-related side effects, and the study is not designed to prove a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANATOMIC STAGE I BREAST CANCER AJCC V8 ANATOMIC STAGE II BREAST CANCER AJCC V8 ANATOMIC STAGE III BREAST CANCER AJCC V8 BREAST CARCINOMA TRIPLE-NEGATIVE BREAST CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Mayo Clinic in Arizona

    RECRUITING

    Scottsdale, Arizona, 85259, United States

    Contact Email: •••••@•••••

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