5-Day radiation for breast cancer: a game changer?

NCT ID NCT06954831

Recruiting now Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing a new, ultra-short radiation schedule for women with stage I-III breast cancer who have had a lumpectomy. Instead of the usual 3-4 weeks of daily radiation, this approach delivers the entire course in just 5 days. The goal is to see if this shorter treatment is as good at preventing cancer from coming back while being more convenient and less burdensome for patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy
What this could lead to: If this works, it could offer a much shorter, more convenient radiation schedule for early-stage breast cancer patients after lumpectomy, potentially improving quality of life.
What could go wrong: This is a small, early-phase trial (82 participants) focused on cosmetic outcomes, not survival. The shorter schedule may not be as effective or could have different side effects compared to standard radiation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANATOMIC STAGE I BREAST CANCER AJCC V8 ANATOMIC STAGE II BREAST CANCER AJCC V8 ANATOMIC STAGE III BREAST CANCER AJCC V8 BREAST CARCINOMA

Contacts and locations

Locations

City of Hope Antelope Valley
RECRUITING

Lancaster, California, 93534, United States
City of Hope Medical Center
RECRUITING

Duarte, California, 91010, United States
City of Hope South Pasadena
RECRUITING

South Pasadena, California, 91030, United States
City of Hope Upland
RECRUITING

Upland, California, 91786, United States
City of Hope at Arcadia
RECRUITING

Arcadia, California, 91007, United States
City of Hope at Irvine Lennar
NOT_YET_RECRUITING

Irvine, California, 92618, United States
City of Hope at South Bay
RECRUITING

Torrance, California, 90503, United States

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