Can a common diabetes drug protect breast cancer survivors from insulin resistance?
NCT ID NCT06763328
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase III trial tests whether metformin, a drug that lowers blood sugar, can prevent or reverse insulin resistance in women with stage I-III breast cancer who have completed chemotherapy. Insulin resistance is a risk factor for diabetes and heart disease, and chemotherapy may worsen it. The study will compare metformin plus standard diet and exercise education to standard care alone in 80 women over 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Metformin
- What this could lead to
- If it works, this could point toward a way to reduce the risk of diabetes and heart disease in breast cancer survivors after chemotherapy.
- What could go wrong
- This is a relatively small, early-phase trial (80 participants) and the impact of metformin in this specific group is unknown. It may not show a clear benefit over standard care alone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
City of Hope Medical Center
RECRUITINGDuarte, California, 91010, United States
-
UC San Diego Moores Cancer Center
NOT_YET_RECRUITINGLa Jolla, California, 92093, United States
-
University of California-Riverside
NOT_YET_RECRUITINGRiverside, California, 92521, United States
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