INVASIVE BREAST CARCINOMA

This early-phase trial is testing a modified measles virus (MV-s-NAP) that is injected directly into tumors in people with metastatic breast cancer. The virus is designed to kill cancer cells and also carry an extra protein to boost the immune response. Researchers are monitoring…

This study tests a new radiation approach for early breast cancer that uses real-time MRI guidance to deliver just three high-dose sessions over one week, instead of the usual several weeks. The goal is to see if this shorter treatment is safe, preserves the breast's appearance, …

This phase III trial tests whether metformin, a drug that lowers blood sugar, can prevent or reverse insulin resistance in women with stage I-III breast cancer who have completed chemotherapy. Insulin resistance is a risk factor for diabetes and heart disease, and chemotherapy ma…

This study tests whether adding a personalized vaccine (made from unique tumor proteins) to a combination of chemotherapy and two immunotherapy drugs can better control metastatic triple-negative breast cancer. About 70 participants will be randomly assigned to receive the vaccin…

This early-phase trial tests the safety and best dose of a new drug combination—pidnarulex plus trastuzumab deruxtecan—in people with advanced breast cancer and other solid tumors that have the HER2 protein. The study enrolls 36 adults whose cancer has spread or cannot be surgica…

This study is for women aged 65 and older with low-risk breast cancer who have had a lumpectomy. It compares two follow-up treatments: a short course of targeted radiation (5 sessions) versus 5 years of hormone pills. The main goal is to see which approach gives a better quality …

This study is for people with certain types of breast cancer (HER2-positive or triple-negative) who have a complete response to initial drug therapy. It tests whether they can safely skip surgery and only receive radiation, or skip radiation if surgery shows no cancer left. For a…

This study tests whether women with breast cancer who have no signs of cancer in their armpit lymph nodes after chemotherapy can safely skip armpit surgery. About 464 participants will be randomly assigned to either have or skip the surgery. The goal is to see if skipping surgery…

This study is testing whether adding calorie restriction to a precise, high-dose radiation treatment (SABR) before surgery can shrink breast tumors more than radiation alone. About 80 adults with early-stage breast cancer will be randomly assigned to either standard dietary advic…

This study is for people with advanced breast cancer who cannot or choose not to have surgery. Researchers want to see if adding radiation therapy to standard medications can shrink the cancer and keep it from getting worse. About 30 participants will receive radiation and be mon…

This study tests whether giving radiation in 3 treatments over 1.5 days is safe and effective for women with early-stage breast cancer after lumpectomy. About 170 women aged 45-79 will participate. The goal is to see if this shorter course causes fewer side effects and maintains …

This study tests a new handheld device that uses light and artificial intelligence to check for leftover cancer cells right after a breast lump is removed. The goal is to help surgeons remove all cancer in one go, avoiding a second surgery. About 104 women having breast-conservin…

This study tests a new imaging system that uses light to monitor how breast cancer responds to chemotherapy before surgery. Researchers want to see if it can accurately predict when the cancer is completely gone. The study involves 15 women with specific types of breast cancer. I…

This study tests a special MRI technique called TMEM-MRI that looks at the tumor environment to see how likely breast cancer is to spread. About 95 women with operable breast cancer will get this MRI before their standard biopsy or surgery. The goal is to see if this imaging meth…

This study tests if repairing the lymphatic system during breast cancer surgery can prevent lymphedema, a painful arm swelling. 50 women with breast cancer will receive this reconstruction. The goal is to see if this approach reduces the risk of developing lymphedema.

This study compares a new single-port robot-assisted breast-conserving surgery done through the armpit with standard open surgery for early-stage breast cancer. The goal is to see if the robotic method is safe, effective, and leads to better quality of life and cosmetic results. …

This pilot study is testing a new, less invasive breast surgery called endoscopic video-assisted nipple-sparing mastectomy (E-NSM) for women with early-stage breast cancer or those at high risk. The goal is to see if this technique can reduce surgical trauma and improve cosmetic …

This study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…

This study collects blood samples and health information from 1,300 women who have had stage I-III breast cancer and finished active treatment. The goal is to create a biorepository that scientists can use in the future to explore links between genes, molecules, and long-term can…

This study looks at how the COVID-19 pandemic impacted out-of-pocket costs, lost wages, and unemployment for 600 breast cancer patients undergoing surgery. Participants will fill out questionnaires about their financial experiences. The goal is to understand the financial toxicit…

This study looks at how radiation therapy changes immune cells inside breast cancer tumors. Researchers want to see if radiation helps immune cells enter the tumor to fight cancer. The study involves 36 adults with invasive breast cancer who will receive radiation and have tumor …

This study tests a decision-making tool for women newly diagnosed with early-stage breast cancer who are considering removing the healthy breast as a preventive measure. The tool aims to improve knowledge and reduce uncertainty about the choice. Only 15 participants are enrolled,…

This study creates a registry for people with inflammatory breast cancer, a rare and aggressive form of the disease. Researchers will collect blood, tissue, and stool samples along with medical information from up to 1,200 participants. The goal is to build a resource for future …

This study is looking at small molecules called microRNAs in the blood of 80 women with breast cancer. Researchers want to see if changes in these molecules can predict how well chemotherapy works before surgery. The goal is to find a simple blood test that helps doctors choose t…

This study compares two methods for marking non-palpable breast tumors before surgery: magnetic clips and traditional metal wires. Researchers will track costs, how well the marker finds the tumor, and patient satisfaction in 772 women across France. The goal is to see if magneti…

This study looks at whether a less invasive procedure called sentinel lymph node biopsy can be safely used after chemotherapy in people with inflammatory breast cancer. Traditionally, these patients need more extensive surgery because the cancer is advanced. The study will check …