INVASIVE BREAST CARCINOMA

This study tests whether giving an extra dose of radiation (a boost) before breast cancer surgery is safe and effective. About 103 people with early-stage, non-metastatic breast cancer will receive the boost, followed by standard radiation and surgery. The goal is to better targe…

This study tests whether platinum-based chemotherapy (cisplatin or carboplatin) is better than capecitabine at preventing breast cancer from coming back in people with a specific type of triple-negative breast cancer (basal-like) that was not completely removed by initial chemoth…

This study tests whether combining an immunotherapy drug (avelumab) with other medications can help shrink or control advanced triple-negative breast cancer that has spread or cannot be removed by surgery. About 145 adults with stage IV or recurrent triple-negative breast cancer …

This phase 3 study tests whether adding tucatinib to the targeted therapy T-DM1 can better prevent HER2-positive breast cancer from coming back in high-risk patients. About 1,056 participants who still have cancer after initial treatment will receive either T-DM1 alone or T-DM1 p…

This large phase 3 trial studied over 5,000 women with hormone receptor-positive, HER2-negative breast cancer that had spread to 1-3 lymph nodes. Participants received standard hormone therapy (tamoxifen or an aromatase inhibitor) either alone or with chemotherapy. The goal was t…

This study looks at whether combining a nightly fast (time-restricted eating) with the diabetes drug metformin can reduce breast cancer cell growth in women with early-stage invasive breast cancer or ductal carcinoma in situ (DCIS). About 120 participants will follow the fasting …

This phase 3 trial tests whether adding the immunotherapy drug pembrolizumab after standard chemotherapy helps prevent triple-negative breast cancer from returning. About 1,155 patients with residual cancer after chemo are randomly assigned to receive pembrolizumab or a placebo. …

This early-phase study tests the safety and best doses of three drugs—entinostat, nivolumab, and ipilimumab—given together to people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if this combination can help the immune system figh…

This study tests a drug called sacituzumab govitecan in 44 people with HER2-negative breast cancer that has spread to the brain. The drug works like a smart bomb, attaching to cancer cells and delivering chemotherapy directly to them. The goal is to see if it can shrink brain tum…

This study tests a combination of targeted drugs (ribociclib, tucatinib, trastuzumab) for HER2-positive breast cancer that has spread or is in early stages. The goal is to see if these drugs are safe and can shrink tumors before surgery better than standard chemotherapy. About 18…

This study tests whether the drug ixabepilone can help people with HER2-negative breast cancer whose tumors didn't fully disappear after standard chemotherapy. About 116 participants will either receive ixabepilone or be observed. The goal is to see if the drug can stop cancer fr…

This study tested whether giving chemotherapy (paclitaxel and cyclophosphamide) with or without the targeted drug trastuzumab before surgery helps shrink breast cancer tumors in 92 women with early-stage or locally advanced breast cancer. The goal was to see if the treatment redu…

This study tested a shorter course of radiation (hypofractionation) to the breast and nearby lymph nodes in 137 women with node-positive breast cancer. The goal was to see if this approach reduces long-term side effects like arm swelling (lymphedema) while still controlling cance…

This study tests whether adding an immunotherapy drug (atezolizumab) to standard chemotherapy before surgery helps shrink tumors more than chemo alone in people with stage II-III triple negative breast cancer. About 67 participants received either chemo alone or chemo plus atezol…

This study tests whether giving two immunotherapy drugs (decitabine and pembrolizumab) before standard chemotherapy can increase immune cell activity in breast tumors. It involves 46 people with locally advanced HER2-negative breast cancer, divided by hormone receptor status. The…

This study tests whether giving a higher dose of radiation to only the part of the breast where cancer started (instead of the whole breast) can reduce side effects and still control the cancer. About 928 women with early-stage breast cancer who had lumpectomy will receive this s…

This study tests whether a shorter course of radiation (hypofractionated) after mastectomy works as well as standard radiation to prevent breast cancer from coming back. About 900 women with stage II to IIIA breast cancer who had a mastectomy and reconstruction are taking part. T…

This study tests whether giving radiation therapy before surgery can shrink tumors in people with hormone receptor-positive, HER2-negative breast cancer. The goal is to make the tumor smaller so less healthy tissue needs to be removed during surgery. The trial involves 25 adults …

This study looks at whether women with HER2-positive breast cancer who have no cancer left after initial treatment can safely receive fewer chemotherapy drugs after surgery. About 2,175 participants will get a combination of paclitaxel, trastuzumab, and pertuzumab before surgery,…

This study compares two different chemotherapy combinations given before surgery for a fast-growing, hard-to-treat type of breast cancer called triple-negative inflammatory breast cancer. Researchers want to see if adding a targeted drug called panitumumab to standard chemotherap…

This study tests whether a special PET/CT scan (FDG-PET/CT) can predict how well HER2-positive breast cancer responds to chemotherapy before surgery. About 235 adults with stage II-III breast cancer will get a scan early in treatment to see if it accurately identifies who will ha…

This study compares two over-the-counter creams, Aquaphor and Miaderm, to see which one better treats the painful skin rash caused by radiation therapy in breast cancer patients. About 208 women receiving radiation after breast cancer surgery will use one of the creams and report…

This study tests whether adding text message reminders and/or telephone counseling helps breast cancer patients take their daily hormone therapy pills more consistently. About 1,167 women with early-stage hormone receptor-positive breast cancer will be followed for up to two year…

This study tests whether a shorter course of higher-dose radiation works as well as the standard longer course for people with early-stage breast cancer or a pre-cancerous condition called DCIS. About 300 participants received either the shorter or standard radiation schedule. Th…

This study looks at how well proton beam radiation works for women with early-stage breast cancer (stages 0 to II). The goal is to see if this type of radiation can kill cancer cells while causing fewer side effects and better cosmetic results compared to standard radiation. Abou…

This study compares a 3-week course of radiation to the standard 5-week course for breast cancer patients who also need radiation to nearby lymph nodes. The goal is to see if the shorter treatment reduces arm swelling (lymphedema) while keeping the risk of cancer returning low. A…

This study looks at whether testing tumor genes can help predict if HER2-negative breast cancer will respond to chemotherapy or hormone therapy. About 1,100 people with stage I to III breast cancer will have their tumor samples analyzed. The goal is to see if this genetic testing…

This study looks at whether certain genes make African American women with breast cancer more likely to develop nerve damage from chemotherapy drugs like docetaxel or paclitaxel. About 249 women with stage I-III breast cancer took part. The goal is to find out if a genetic test c…

This study involves 500 women in northern France diagnosed with invasive breast cancer in 2024. Researchers want to understand why some women wait longer between noticing a symptom and starting treatment. Participants fill out a one-time questionnaire about their feelings, behavi…

This study aims to create a large collection of blood and tumor samples from 300 people whose breast cancer has spread or returned. By linking these samples with medical information, researchers hope to learn why the cancer spreads and why people respond differently to treatments…

This study looks at how a medicated gel (afimoxifene) is absorbed through the skin of the breast in women who have had radiation therapy for breast cancer. Researchers want to understand if skin type, blood vessels, or past radiation affect how much of the drug reaches breast tis…

This study planned to give high doses of vitamin D to women with breast cancer before their surgery, to see if it changed certain markers in the cancer cells. The goal was to learn how vitamin D might affect the cancer, not to cure it. However, the study was withdrawn before any …

This study looks at how chemotherapy given before surgery changes the immune system in people with operable breast cancer. Researchers will collect blood samples from 38 participants to see if certain immune cells are linked to how well the tumor responds to treatment. The goal i…

This study collects tissue and blood samples, along with medical information, from 1,600 people with various advanced cancers. Researchers will store and study these samples over time to learn how cancer changes and why some treatments stop working. The goal is to improve future …