INVASIVE BREAST CARCINOMA

This large Phase 3 trial is testing whether adding a year of the immunotherapy drug pembrolizumab after standard chemotherapy and surgery can help prevent cancer from returning in patients with high-risk triple-negative breast cancer. The study enrolled over 1,100 patients whose …

This study is testing if adding a targeted drug called panitumumab to standard chemotherapy works better than chemotherapy alone before surgery for a fast-growing, hard-to-treat type of breast cancer. It aims to see which combination shrinks the tumor more effectively, potentiall…

This study is testing a new approach for patients with a specific type of breast cancer (HER2-positive, stage II-IIIa). The goal is to see if patients who have no detectable cancer left after initial pre-surgery treatment can safely skip additional, stronger chemotherapy after th…

This study is testing whether a shorter, 3-week radiation schedule is as effective as the standard 5-week schedule for preventing breast cancer from returning in the lymph nodes. It will also closely compare side effects, especially arm swelling (lymphedema), between the two grou…

This study is for people with a type of breast cancer (HER2-negative) that did not completely disappear after standard chemotherapy before surgery. It tests whether adding a drug called ixabepilone after surgery helps control the cancer better than standard follow-up care alone. …

This study is testing whether simple support tools can help breast cancer patients remember to take their daily hormone therapy pills correctly. Researchers are comparing text message reminders, phone-based counseling sessions, or both, against standard care to see which method w…

This study is testing a shorter, more targeted form of radiation therapy using proton beams for patients with early-stage breast cancer. The goal is to see if this approach effectively controls the cancer while causing fewer side effects and better cosmetic results compared to tr…

This study is for patients with a specific, aggressive type of breast cancer (triple-negative, basal-like) where cancer cells remain after initial chemotherapy and surgery. It aims to find out which of two follow-up chemotherapy drugs—platinum-based drugs (cisplatin/carboplatin) …

This study is testing whether giving part of the radiation treatment before breast cancer surgery is safe and might lead to better cosmetic outcomes. The research involves 103 patients with early-stage breast cancer that hasn't spread. Doctors hope that targeting the radiation wh…

This study is testing if giving a short, focused dose of radiation right before breast cancer surgery can help the patient's own immune system fight the tumor. It involves 25 patients with a common type of hormone-positive, HER2-negative breast cancer. The main goal is to see if …

This study is testing if adding an immunotherapy drug (atezolizumab) to standard chemotherapy before surgery works better for treating early-stage triple-negative breast cancer. It will compare two groups: one gets chemo alone, and the other gets chemo plus the immunotherapy drug…

This study is testing whether a shorter, more intense 3-week radiation schedule works as well as the standard 5-week schedule for women with early-stage breast cancer. It aims to see if the shorter treatment is just as effective at controlling cancer while possibly causing fewer …

This early-stage study is testing the safety and best dose of a three-drug combination (entinostat, nivolumab, and ipilimumab) for people with advanced solid tumors that have spread and are hard to treat. The goal is to see if boosting the immune system with two drugs while using…

This study is comparing two ways to give radiation after breast cancer surgery. It tests if a shorter, 5-day treatment that targets only the tumor area is as safe and effective as the standard 15-day treatment. The goal is to see if the shorter course can control the cancer just …

This study tested a treatment plan for people with early-stage breast cancer who had not yet had surgery. The goal was to see if giving strong chemotherapy before surgery, with or without the drug trastuzumab (Herceptin), could shrink tumors effectively and be well-tolerated. Res…

This large study is testing whether adding the drug tucatinib to standard treatment (T-DM1) works better at preventing breast cancer from coming back. It is for people with a specific type of high-risk, HER2-positive breast cancer who still have some cancer cells after their init…

This study is testing if combining time-restricted eating (fasting for at least 16 hours each night) with the diabetes drug metformin can slow the growth of early-stage breast cancer. It involves 120 women who are scheduled for surgery. The goal is to see if this combination redu…

This large study is comparing two different schedules of radiation therapy given after mastectomy to prevent breast cancer from coming back. It is testing if a shorter 3-4 week schedule is as safe for breast reconstruction and works as well as the standard 5-6 week schedule. The …

This large study aimed to find out if adding chemotherapy to standard hormone therapy helps women with a specific type of early-stage breast cancer that has spread to 1-3 lymph nodes. Over 5,000 participants were randomly assigned to receive either hormone therapy alone or hormon…

This study is testing a special imaging scan (FDG-PET/CT) to see if it can predict how well standard chemotherapy works for patients with HER2-positive breast cancer before they have surgery. The scan is done early in treatment to measure changes in the cancer's activity. If succ…

This study aims to find out if one common skin cream works better than another at treating or preventing painful skin rashes caused by radiation therapy for breast cancer. About 208 patients will be randomly assigned to use either Aquaphor ointment or Miaderm cream on their skin …

This study aims to understand how chemotherapy given before breast cancer surgery affects patients' immune systems. Researchers will collect blood samples from 38 participants with operable breast cancer at different points during their treatment. The goal is to learn how the imm…

This study aims to understand why a gel medication for breast cancer might be absorbed differently through each woman's skin. Researchers are testing the gel on breast cancer survivors who have had radiation on one breast, to see how skin features and past radiation affect drug d…

This study aims to validate a genetic test that might predict which African American women with early-stage breast cancer are at higher risk for nerve damage (neuropathy) from common chemotherapy drugs. It also compares two different chemotherapy schedules to see which one might …

This study aims to collect tissue samples, blood, and medical information from 300 patients with advanced breast cancer that has spread. Researchers will analyze these samples to understand why breast cancer spreads to other parts of the body and why different patients respond di…

This study is testing whether analyzing the genetic makeup of breast tumors can help predict which standard treatments will work best for individual patients. Researchers are enrolling 1,100 people with early-stage breast cancer to see if genetic testing can accurately identify t…