INVASIVE BREAST CARCINOMA

This study is testing if reducing calorie intake by 25% while receiving a highly focused, intense form of radiation before surgery helps shrink breast tumors more than radiation alone. It will involve 80 women with early-stage breast cancer. The goal is to see if this combined ap…

This study is testing if breast cancer patients who respond exceptionally well to initial drug therapy can safely skip surgery or radiation. It is for women with early-stage breast cancer where a special biopsy shows no cancer remains after the drug treatment. The goal is to see …

This early-stage trial is testing a modified measles virus (MV-s-NAP) that is injected directly into tumors in patients with metastatic breast cancer. The goal is to see if the virus can safely infect and kill cancer cells while also stimulating the patient's immune system to att…

This early-phase study aims to find a safe and tolerable dose of a new drug combination for people with advanced breast cancer and other solid tumors that have a protein called HER2. The trial will test pidnarulex, which aims to stop tumor cell growth, together with an existing t…

This study is testing whether adding a personalized vaccine to standard immunotherapy and chemotherapy helps control advanced triple-negative breast cancer that has spread. It will compare two groups of about 70 patients total: one gets the vaccine plus standard drugs, the other …

This study aims to collect blood and tissue samples to help develop a single blood test that can detect many different cancers early. Researchers will enroll 2,000 people, including those with cancer and those without, to create a reference set for testing. The goal is to validat…

This study is testing whether a less invasive lymph node procedure can safely replace more extensive surgery for certain inflammatory breast cancer patients. Researchers want to see if they can accurately identify the first lymph nodes where cancer might spread in patients who re…

This study is testing whether adding the diabetes medication metformin to standard healthy lifestyle advice can better prevent or reverse insulin resistance in women who have finished chemotherapy for early-stage breast cancer. Researchers want to see if metformin helps normalize…

This study is testing a new online tool designed to help women with early-stage breast cancer make informed decisions about surgery. The tool provides clear information about the risks of cancer in the other breast and the potential benefits of removing it preventively. Patients …

This study is creating a large collection of medical information and biological samples from people with inflammatory breast cancer. Researchers will gather blood, tissue, stool samples, and health data from up to 1,200 participants. The goal is to build a research resource that …

This study is testing whether a new optical scanning device called NearWave can monitor how breast cancer responds to chemotherapy before surgery. Researchers will use the device on 15 patients receiving chemotherapy to see if it collects good enough data to predict treatment suc…

This study is creating a large collection of blood samples and health information from people who have survived early-stage breast cancer. The goal is to build a resource for future scientists to study how factors like genetics, lifestyle, and environment affect long-term health …

This study aims to understand how the COVID-19 pandemic affects the financial burden on breast cancer patients undergoing surgery. Researchers will survey 600 patients about out-of-pocket costs, lost wages, and economic strain before and after their operations. The goal is to ide…

This study is collecting tissue and blood samples from cancer patients over time to create a research resource called a biobank. Researchers will analyze these samples to understand how cancer changes during treatment and why some treatments stop working. The goal is to help scie…