INVASIVE BREAST CARCINOMA

This study tests whether adding a personalized vaccine (made from unique tumor proteins) to a combination of chemotherapy and two immunotherapy drugs can better control metastatic triple-negative breast cancer. About 70 participants will be randomly assigned to receive either the…

This study looks at whether eating fewer calories while getting focused radiation (SABR) before surgery can shrink breast tumors more than radiation alone. About 80 adults with early-stage breast cancer will be randomly assigned to one of two groups. The goal is to see if the com…

This early-stage trial tests a modified measles virus (MV-s-NAP) injected directly into tumors of people with metastatic breast cancer. The virus is designed to kill cancer cells and boost the immune system. Researchers aim to find the safest dose and see if it shrinks tumors. Ab…

This study compares a new single-port robotic surgery done through the armpit with standard open surgery for early-stage breast cancer. The goal is to see if the robotic method is safe, effective, and leaves no visible scar on the chest. About 100 women aged 18 to 65 who want a s…

This study looks at whether metformin, a common diabetes medicine, can help prevent or reverse insulin resistance (a step toward diabetes) in women who finished chemotherapy for early-stage breast cancer. About 200 women will either get metformin plus standard diet and exercise a…

This study is testing whether women with certain types of breast cancer (HER2-positive or triple-negative) who have no cancer left after initial drug therapy can safely skip surgery and just receive radiation. For others with ER-positive/HER2-negative cancer, it tests skipping ra…

This early-phase trial tests the safety and best dose of two drugs given together for people with advanced breast cancer or other solid tumors that have a protein called HER2. The drugs are pidnarulex (which stops cancer cells from repairing themselves) and trastuzumab deruxtecan…

This study tests a new, non-invasive imaging device that uses light to monitor how breast tumors respond to chemotherapy. Researchers want to see if it can accurately predict when the cancer has been completely eliminated (called a complete pathological response). The study invol…

This study looks at how the COVID-19 pandemic impacted the financial costs for breast cancer patients having surgery, including out-of-pocket expenses and lost wages. Researchers will survey 600 patients to understand the economic strain and how the pandemic may have made things …

This study collects blood samples and health information from 1,300 women who have had stage I-III breast cancer and finished active treatment. The goal is to create a biorepository for future research into how individual factors affect long-term cancer outcomes. Participants wil…

This study looks at whether a less invasive procedure called sentinel lymph node biopsy can be safely used after chemotherapy in people with inflammatory breast cancer. Normally, these patients need more extensive surgery because their cancer is advanced. The study will enroll 75…

This study collects blood and tissue samples from 2000 people—some with cancer, some without—to help researchers develop and improve blood tests that can detect many types of cancer early. Participants provide samples that are stored and later used to test new diagnostic methods.…

This study creates a registry of medical information and biological samples (blood, tissue, stool) from people with inflammatory or invasive breast cancer. The goal is to help researchers better understand and treat inflammatory breast cancer in the future. Participants must be d…

This study is looking at tiny molecules in the blood called microRNAs to see if they can predict how well breast cancer responds to chemotherapy given before surgery. Researchers will collect blood samples from 80 women with breast cancer before and after chemotherapy. The goal i…

This study looks at how radiation therapy changes immune cells inside breast cancer tumors. Researchers want to see if radiation helps immune cells enter the tumor and fight cancer. About 36 adults with invasive breast cancer will have tumor samples taken before and after radiati…

This study is testing a decision-making tool for women newly diagnosed with early-stage breast cancer. The tool helps them weigh the pros and cons of having a preventive mastectomy on the healthy breast. Researchers want to see if the tool is easy to use, improves knowledge, and …