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Measles virus turned against breast cancer tumors

NCT ID NCT04521764

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This early-phase trial is testing a modified measles virus (MV-s-NAP) that is injected directly into tumors in people with metastatic breast cancer. The virus is designed to kill cancer cells and also carry an extra protein to boost the immune response. Researchers are monitoring up to 54 participants to find the safest dose and see if the virus can shrink both injected and non-injected tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
modified measles virus (MV-s-NAP)
What this could lead to
If it works, this could point toward a new way to treat metastatic breast cancer by using a virus to attack tumors and boost the immune system.
What could go wrong
This is a very early phase I trial with only 54 people, so it is not yet known if the virus is safe or effective. The virus may cause side effects or fail to shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast adenocarcinoma breast cancer breast carcinoma breast neoplasm invasive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANATOMIC STAGE IV BREAST CANCER AJCC V8 INVASIVE BREAST CARCINOMA METASTATIC BREAST ADENOCARCINOMA RECURRENT BREAST CARCINOMA STAGE IV BREAST CANCER AJCC V6 AND V7

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Mayo Clinic in Rochester

    RECRUITING

    Rochester, Minnesota, 55905, United States

    Contact Email: •••••@•••••

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