Proton beam radiation aims to spare healthy tissue in breast cancer treatment

NCT ID NCT01245712

First seen Nov 21, 2025 · Last updated Jun 22, 2026 · Updated 26 times

Summary

This phase II trial is testing a type of radiation called proton beam therapy for women with early-stage breast cancer (stage 0 to II). The goal is to see if this targeted approach can kill cancer cells while causing less damage to normal tissue, leading to fewer side effects and better cosmetic outcomes. About 200 women will receive the treatment and be followed for side effects and breast appearance.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Proton beam radiation therapy

What this could lead to

If successful, this could offer a more precise radiation option for early breast cancer with fewer side effects and better cosmetic results.

What could go wrong

This is a phase II trial with 200 participants, so results are still preliminary. It may not prove better than standard radiation, and some skin reactions or other side effects are possible.

Conditions

The condition(s) this trial relates to.

breast carcinoma in situ breast neoplasm ductal breast carcinoma in situ

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.