BREAST ADENOCARCINOMA

This study tests a new drug called Rina-S in people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to see if Rina-S is safe and how well it works against cancers like ovarian, lung, and breast cancer. About 764 participants will receive th…

This study is for people with breast cancer whose tumors did not shrink after two rounds of standard chemotherapy. Researchers want to see if adding a special type of radiation (SBRT) to the remaining chemotherapy can help eliminate the cancer more effectively. About 96 participa…

This study looks at whether adding radiation therapy to standard medications can shrink or slow advanced breast cancer in people who cannot or choose not to have surgery. About 30 adults with invasive breast cancer that has spread locally or to distant sites will receive radiatio…

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors. The goal is to see if this combination is safe and helps the immune system fight cancer more effectively. A…

This study compares two approaches for breast cancer patients who need a mastectomy and radiation. The experimental group gets radiation before surgery with immediate reconstruction, while the standard group gets radiation after surgery with delayed reconstruction. Researchers wa…

This study tests a high-CBD plant extract (BRC-001) to see if it can reduce joint pain and stiffness in women with breast cancer who take aromatase inhibitors (AIs). AIs lower estrogen to prevent cancer return but often cause arthritis-like side effects, leading some women to sto…

This study looks at whether a skin care program can improve skin quality and self-esteem in breast cancer survivors who are starting a type of hormone therapy called aromatase inhibitors. The study will include 25 women with early-stage breast cancer. Researchers will use special…

This study looks at whether a specific gene change (HSD3B1) affects how well the drug letrozole works in postmenopausal women with early-stage, hormone-sensitive breast cancer. Researchers will measure changes in tumor markers before and after treatment. The goal is to understand…

This study follows 2000 people with early-stage, hormone-positive breast cancer to see how doctors decide on treatments and how patients fare over 10 years. It compares those who get a special gene test (EndoPredict) with those who don't. The goal is to learn which treatments wor…

This study collects blood and tumor tissue from 230 adults with HER2-positive breast cancer (stages I-IV) who are starting anti-HER2 drugs like trastuzumab. Researchers want to learn how the immune system responds to these treatments. The goal is to better understand the connecti…

This study looks at how chemotherapy changes the way the body controls blood pressure and exercise in breast cancer patients. Researchers will compare 24 women who finished chemo with healthy women of similar age and fitness. The goal is to understand why exercise becomes harder …