BREAST ADENOCARCINOMA

This trial is for people with breast cancer whose tumors have not shrunk after two rounds of standard chemotherapy before surgery. It tests if adding a short, targeted course of radiation (SBRT) to the continuing chemotherapy can better eliminate the cancer and allow for breast-c…

This study is testing whether a specialized radiation treatment can help control breast cancer in patients who cannot or choose not to have surgery. It aims to see if this approach safely prevents cancer from worsening while maintaining quality of life. The research focuses on pa…

This study is testing if changing the order of breast cancer treatments improves how women feel about their bodies after surgery. It compares giving radiation therapy before breast removal and reconstruction (the new approach) to the standard method of radiation after surgery. Th…

This study is testing a new, personalized vaccine designed to target the unique proteins on a patient's own cancer cells. It is being given alongside an existing immunotherapy drug (pembrolizumab) to see if the combination is safe and can help control advanced solid tumors that h…

This study is testing a new drug called Rina-S in people whose solid tumor cancers have spread or cannot be removed by surgery. The main goals are to find a safe dose and see if the drug can shrink tumors. It is for people with several types of advanced cancer, including ovarian,…

This study aims to see if skincare consultations can improve skin appearance and quality of life for breast cancer survivors who are starting aromatase inhibitor therapy. Researchers will enroll 25 postmenopausal women with early-stage breast cancer to track skin changes using sp…

This study aims to understand why breast cancer patients often struggle with exercise after chemotherapy. Researchers will compare 24 women who recently finished chemo with 24 healthy women, measuring how their hearts and nerves respond to gentle leg movements and blood pressure …

This study aims to understand how the immune system reacts during standard treatments for HER2-positive breast cancer. Researchers will collect blood and tissue samples from 230 patients with stage I-IV breast cancer who are receiving or have received anti-HER2 drugs like trastuz…

This study aims to understand if a specific gene mutation (HSD3B1) makes the breast cancer drug letrozole less effective. Postmenopausal women with early-stage, hormone-sensitive breast cancer will take letrozole for a few weeks before their standard surgery. Researchers will com…

This study is a long-term registry that will follow 2,000 people with a common type of early breast cancer for up to 10 years. It aims to understand how doctors and patients make decisions about treatments like chemotherapy and hormone therapy, especially when a specific gene tes…