BREAST ADENOCARCINOMA

This study tests a personalized vaccine made from a patient's own tumor proteins, given alone or with the immunotherapy drug pembrolizumab. The goal is to see if the combination is safe and helps the immune system attack advanced solid tumors. About 132 people with various advanc…

This phase 3 trial tests whether a shorter, higher-dose radiation schedule (3 weeks) is as safe and effective as the standard 5-week schedule for women with high-risk breast cancer who have had a mastectomy and immediate implant reconstruction. The study will enroll 506 women and…

This study tests a new drug, Rina-S, in people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to see if Rina-S is safe and how well it works against cancers like ovarian, lung, and breast cancer. About 884 participants will receive the dru…

This study is for people with breast cancer whose tumors did not shrink after two rounds of standard chemotherapy. It tests whether adding a short course of targeted radiation (SBRT) to continued chemotherapy can help eliminate more cancer before surgery. About 96 participants wi…

This study is for people with advanced breast cancer who cannot or choose not to have surgery. Researchers want to see if adding radiation therapy to standard medications can shrink the cancer and keep it from getting worse. About 30 participants will receive radiation and be mon…

This study tests a hydrogel made from bacterial cellulose and coconut oil monolaurin to prevent severe skin reactions in Filipino women with breast cancer undergoing radiation therapy. About 54 participants will apply either the hydrogel or a placebo cream daily. The goal is to s…

This study tests whether a high-CBD plant extract can reduce joint stiffness and pain in women with breast cancer who take aromatase inhibitors. These drugs lower estrogen to prevent cancer return but often cause painful joints, leading some women to stop treatment. The trial wil…

This study compares two approaches for breast cancer patients who need a mastectomy and radiation. The experimental group gets radiation before surgery with immediate breast reconstruction, while the standard group gets radiation after surgery with delayed reconstruction. The goa…

This study collects blood and tumor samples from 230 adults with HER2-positive breast cancer (stages I-IV) who are starting anti-HER2 drugs like trastuzumab. Researchers want to see how the immune system reacts to these treatments. The goal is to learn more, not to test a new the…

This study looks at how aromatase inhibitor therapy changes skin quality and self-esteem in breast cancer survivors. Researchers will use skin imaging and surveys to track changes in 35 women starting this hormone therapy. The goal is to better understand and manage these side ef…

This study follows 2000 people with early-stage, hormone-sensitive breast cancer to see how doctors decide on treatments, especially when using a test called EndoPredict. The goal is to track long-term outcomes like cancer return and survival over 5 to 10 years. No new treatments…

This study looks at how chemotherapy changes certain nerve reflexes that control blood pressure and exercise responses in breast cancer patients. Researchers will compare 24 women who recently finished chemotherapy with healthy volunteers. The goal is to understand these changes …