ANATOMIC STAGE IV BREAST CANCER AJCC V8
Clinical trials for ANATOMIC STAGE IV BREAST CANCER AJCC V8 explained in plain language.
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Could estrogen shrink Hard-to-Treat breast tumors?
Disease control OngoingThis study tests if a form of estrogen called estradiol can help people with a specific type of triple negative breast cancer that has spread. The cancer must have a protein called ER beta, which may make tumors grow slower when exposed to estrogen. The goal is to see if the trea…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 17, 2026 01:02 UTC
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Radioactive bullets target bone tumors in breast cancer trial
Disease control OngoingThis study tests a combination of a radioactive drug (radium-223) and chemotherapy (paclitaxel) in 70 people with advanced breast cancer that has spread to the bones. The radioactive drug acts like calcium and collects in bone tumors to kill cancer cells and ease pain. The goal i…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 17, 2026 01:01 UTC
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Could a new combo drug slow advanced breast cancer?
Disease control OngoingThis phase 3 trial tested whether adding the drug entinostat to standard hormone therapy (exemestane) helps people with advanced hormone receptor-positive breast cancer live longer without their cancer growing. The study included 608 adults whose breast cancer had spread locally …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 17, 2026 00:59 UTC
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Virus injection takes on Hard-to-Treat breast cancer in early trial
Disease control OngoingThis early-phase study tests a new treatment for metastatic triple negative breast cancer, a type that has spread and is hard to treat. The therapy uses a specially designed virus injected directly into tumors to infect and break them down. The main goal is to find the safest dos…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 17, 2026 00:53 UTC
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New drug combo targets BRCA cancers in early trial
Disease control OngoingThis early-phase trial tests a combination of two drugs—niraparib (a PARP inhibitor) and dostarlimab (an immunotherapy)—in people with BRCA-mutated breast, pancreas, or ovarian cancers that have spread or cannot be surgically removed. The goal is to see if the combo can shrink tu…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: University of Washington • Aim: Disease control
Last updated May 17, 2026 00:51 UTC
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New hope for Drug-Resistant breast cancer: experimental combo shows promise
Disease control OngoingThis study tests a new drug (TVB-2640) combined with standard therapies in people with HER2-positive breast cancer that has spread and stopped responding to treatment. The goal is to see if this combination can shrink tumors or slow the disease. The trial involves 17 adults with …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 17, 2026 00:50 UTC
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New drug combo targets tough cancers in early trial
Disease control OngoingThis early-phase trial tests a new drug (BAY 1895344) combined with standard chemotherapy in people with advanced solid tumors, especially bladder cancer. The goal is to find the safest dose and see how well the combination works. About 74 adults with cancers like lung, bladder, …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 15, 2026 11:56 UTC
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Triple-Drug attack on Hard-to-Treat cancers shows early promise
Disease control OngoingThis early-phase study tests the safety and best doses of three drugs—entinostat, nivolumab, and ipilimumab—given together to people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if this combination can help the immune system figh…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 15, 2026 11:55 UTC
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New drug shows promise for breast cancer brain tumors
Disease control OngoingThis study tests a drug called sacituzumab govitecan in 44 people with HER2-negative breast cancer that has spread to the brain. The drug works like a smart bomb, attaching to cancer cells and delivering chemotherapy directly to them. The goal is to see if it can shrink brain tum…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated May 15, 2026 11:55 UTC
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New drug cocktail shows promise against aggressive breast cancer
Disease control OngoingThis study tests a combination of targeted drugs (ribociclib, tucatinib, trastuzumab) for HER2-positive breast cancer that has spread or is in early stages. The goal is to see if these drugs are safe and can shrink tumors before surgery better than standard chemotherapy. About 18…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Disease control
Last updated May 15, 2026 11:54 UTC
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New drug combo shows promise in Tough-to-Treat breast cancer
Disease control OngoingThis study tests two drugs—eribulin (chemotherapy) and copanlisib (targeted therapy)—together in people with metastatic triple-negative breast cancer that has spread or cannot be removed. The goal is to find the safest dose and see if the combination works better than eribulin al…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 13, 2026 15:58 UTC
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New drug cocktail shows promise for Hard-to-Treat breast cancer
Disease control OngoingThis study tests whether adding a drug called copanlisib to the usual two-drug therapy (fulvestrant and abemaciclib) works better for people with a certain type of advanced breast cancer (hormone receptor-positive, HER2-negative) that has spread. About 24 participants will receiv…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 11, 2026 20:48 UTC
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New combo therapy aims to turn tumors against themselves in advanced cancer patients
Disease control OngoingThis early-phase study tests whether a mix of drugs and targeted radiation can help the immune system recognize and attack hard-to-treat solid tumors. About 14 adults with advanced melanoma, breast cancer, or other solid cancers that cannot be surgically removed will receive inje…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: University of Southern California • Aim: Disease control
Last updated May 11, 2026 20:38 UTC
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New combo therapy shows promise for HIV patients with advanced cancer
Disease control OngoingThis early-phase trial is testing the safety of combining two cancer drugs—nivolumab and cabozantinib—in people with HIV who have advanced solid tumors. The study includes 8 participants with various cancers that have spread. The goal is to see if the combination can shrink or st…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 11, 2026 20:38 UTC
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New combo therapy targets hard-to-treat HER2 cancers in early trial
Disease control OngoingThis early-phase trial tests a combination of two drugs—trastuzumab deruxtecan (a targeted chemotherapy) and ceralasertib (a cell-growth blocker)—in people with advanced solid tumors that have a HER2 mutation. The study first finds the safest dose, then compares the combo against…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 06, 2026 16:02 UTC
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New combo therapy shows promise for hard-to-treat breast cancer
Disease control OngoingThis study tests whether a drug called olaparib, which blocks cancer cells from repairing themselves, works better alone or when combined with an immunotherapy drug (atezolizumab) for people with advanced breast cancer that has a specific genetic change (BRCA mutation). About 81 …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 04, 2026 16:18 UTC
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New scan could improve monitoring of bone metastases in breast cancer
Diagnosis OngoingThis study looks at whether a type of PET/CT scan (FDG-PET/CT) can better measure how breast cancer that has spread to the bones responds to treatment. About 138 adults with hormone receptor-positive, HER2-known breast cancer that is mostly in the bones will get the scan before a…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Diagnosis
Last updated May 14, 2026 12:02 UTC
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Can a natural nerve protector stop chemo's painful side effects?
Symptom relief TerminatedThis trial is testing whether a substance called GM1 can prevent or reduce nerve damage caused by paclitaxel chemotherapy. The study involves about 100 people with metastatic breast cancer who are receiving paclitaxel treatment. Researchers want to see if giving GM1 alongside che…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Symptom relief
Last updated Apr 22, 2026 15:58 UTC
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Blood test may tame Chemo's nerve damage
Knowledge-focused TerminatedThis study looks at whether doctors can consistently measure the chemotherapy drug paclitaxel in the blood of cancer patients. The goal is to see if this could help adjust doses to kill cancer while reducing nerve damage, a common side effect. About 22 adults with various solid t…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: Wake Forest University Health Sciences • Aim: Knowledge-focused
Last updated May 17, 2026 00:53 UTC
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Gene test may guide breast cancer treatment choices
Knowledge-focused OngoingThis study looks at whether testing tumor genes can help predict if HER2-negative breast cancer will respond to chemotherapy or hormone therapy. About 1,100 people with stage I to III breast cancer will have their tumor samples analyzed. The goal is to see if this genetic testing…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 17, 2026 00:53 UTC
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Scientists launch biobank to unlock secrets of metastatic breast cancer
Knowledge-focused TerminatedThis study aims to create a large collection of blood and tumor samples from 300 people whose breast cancer has spread or returned. By linking these samples with medical information, researchers hope to learn why the cancer spreads and why people respond differently to treatments…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated May 15, 2026 11:54 UTC
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Cancer fear study pulled before starting
Knowledge-focused TerminatedThis study was designed to see if an online mental health program could help women with advanced gynecologic or breast cancer manage their fear of the cancer returning or getting worse. The program would have been compared to standard educational materials. However, the trial was…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: City of Hope Medical Center • Aim: Knowledge-focused
Last updated May 14, 2026 12:01 UTC
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Massive biobank aims to unlock Cancer's secrets
Knowledge-focused OngoingThis study collects tissue and blood samples, along with medical information, from 1,600 people with various advanced cancers. Researchers will store and study these samples over time to learn how cancer changes and why some treatments stop working. The goal is to improve future …
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated May 07, 2026 18:40 UTC
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Short video boosts cancer Patients' understanding of genetic tests
Knowledge-focused OngoingThis study tests whether watching a short video helps people with metastatic cancer understand tumor genomic testing better. About 243 adults with cancer that has spread will watch the video and answer questions before and after. The goal is to see if the video improves knowledge…
Matched conditions: ANATOMIC STAGE IV BREAST CANCER AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated May 05, 2026 11:53 UTC