ANATOMIC STAGE IV BREAST CANCER AJCC V8

This large, late-stage trial is testing whether adding a new drug called entinostat to standard hormone therapy (exemestane) works better than the hormone therapy alone. It's for people whose hormone-sensitive, advanced breast cancer has continued to grow despite prior treatment.…

This study is testing whether adding an immunotherapy drug (atezolizumab) to a targeted cancer drug (olaparib) works better than the targeted drug alone for people with advanced breast cancer that has a specific genetic flaw (BRCA mutation). The goal is to see if the combination …

This early-stage trial is testing the safety of a new combination treatment for people with advanced cancers that have spread and cannot be removed by surgery. Doctors inject immune-stimulating drugs directly into a tumor, then give a small dose of radiation to that same spot. Th…

This study is testing if adding a new drug called copanlisib to the standard two-drug treatment (fulvestrant and abemaciclib) is more effective for advanced breast cancer that has stopped responding to hormone therapy. It will involve about 24 patients with hormone-positive, HER2…

This study is testing whether adding a radioactive drug called Radium-223 to standard chemotherapy (paclitaxel) works better for people with breast cancer that has spread to their bones. The radioactive drug travels to the bones and aims to kill cancer cells there, potentially sl…

This early-stage study is testing a new combination of two drugs, AZD8186 and docetaxel, for patients with advanced solid tumors that have specific genetic changes (PTEN or PIK3CB mutations). The main goals are to find the safest and most effective dose and to understand the side…

This study is testing whether estradiol, a form of estrogen, can help control advanced triple-negative breast cancer that has a specific biomarker called ER beta. Researchers are giving estradiol pills to 8 postmenopausal women whose cancer has spread and seeing if their tumors s…

This early-stage trial is testing a new drug called BAY 1895344, given alongside standard chemotherapy drugs, in people with advanced solid tumors that have spread. The main goal is to find the safest and most effective dose of this combination. Researchers are especially interes…

This is a small, early-stage safety study testing a combination of two cancer drugs, nivolumab and cabozantinib, in people living with HIV who have advanced solid tumors. The main goal is to see if the two-drug combination is safe and tolerable for this specific patient group. Re…

This study is testing whether adding a new experimental drug, TVB-2640, to standard treatments can help control advanced HER2-positive breast cancer that has spread and is no longer responding to the usual therapies. It involves a small group of patients whose cancer has progress…

This study is testing a personalized treatment method for people with advanced breast, prostate, ovarian, pancreatic, or sarcoma cancers that have spread. Doctors analyze each patient's tumor using genetic and protein tests to understand how the cancer is changing and which drugs…

This early-stage trial is testing a combination of two drugs, niraparib and dostarlimab, for people with advanced breast, ovarian, pancreatic, or related cancers that have a specific genetic change (BRCA mutation) and have stopped responding to standard treatments. The goal is to…

This early-stage study is testing the safety and best dose of a three-drug combination (entinostat, nivolumab, and ipilimumab) for people with advanced solid tumors that have spread and are hard to treat. The goal is to see if boosting the immune system with two drugs while using…

This study is testing if combining two drugs, copanlisib and eribulin, is safe and more effective at controlling advanced triple-negative breast cancer than standard eribulin chemotherapy alone. It involves about 24 patients whose cancer has spread and who have already tried othe…

This is a first-in-human, early-stage safety study testing a new type of cancer treatment called an oncolytic virus. The virus, called CF33-hNIS-antiPDL1, is designed to be injected directly into tumors to infect and break down cancer cells, while also potentially helping the pat…

This study is testing whether a special type of PET/CT scan can better measure how well treatment is working for breast cancer that has spread to the bones. About 138 patients with this type of advanced cancer will get the scan before starting treatment and again 12 weeks later. …

This study aimed to test an online mental health program designed to help women with advanced breast or gynecologic cancers manage their fear of the cancer coming back or getting worse. Participants would have been randomly assigned to either the main program, which taught coping…

This trial is testing whether a substance called GM1 can prevent or reduce nerve damage (neuropathy) caused by paclitaxel chemotherapy. It involves about 98 people with metastatic breast cancer who are receiving this specific chemo. Participants are randomly assigned to receive e…

This study aims to collect tissue samples, blood, and medical information from 300 patients with advanced breast cancer that has spread. Researchers will analyze these samples to understand why breast cancer spreads to other parts of the body and why different patients respond di…

This study aims to see if doctors can reliably measure the amount of a common chemotherapy drug (paclitaxel) in a patient's blood. The goal is to learn if tracking these levels can help find the right dose to fight cancer while reducing a severe side effect: nerve damage that cau…

This study is testing whether analyzing the genetic makeup of breast tumors can help predict which standard treatments will work best for individual patients. Researchers are enrolling 1,100 people with early-stage breast cancer to see if genetic testing can accurately identify t…

This study is testing whether a short educational video can help patients with advanced cancer better understand tumor genomic testing. It involves 243 adults with metastatic breast or lung cancer who are already scheduled for this type of testing. Researchers will measure if wat…