New drug combo aims to outsmart resistant breast cancer
NCT ID NCT03939897
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing whether adding a drug called copanlisib to the standard two-drug therapy (fulvestrant and abemaciclib) can better control hormone receptor-positive, HER2-negative metastatic breast cancer that has stopped responding to hormone therapy. The study involves 24 participants and primarily looks at safety and side effects, while also measuring how long the cancer stays under control. The goal is to find a more effective treatment option for this type of advanced breast cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Copanlisib (added to fulvestrant and abemaciclib)
- What this could lead to
- If it works, this could lead to a more effective treatment option for people with hormone receptor-positive, HER2-negative metastatic breast cancer that has stopped responding to hormone therapy.
- What could go wrong
- This is a very early phase I trial with only 24 participants, so the main goal is safety, not effectiveness. The added drug may cause more side effects without improving outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Bellevue Hospital Center
New York, New York, 10016, United States
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Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, 10016, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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Siteman Cancer Center at Christian Hospital
St Louis, Missouri, 63136, United States
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Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, 63141, United States
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Siteman Cancer Center-South County
St Louis, Missouri, 63129, United States
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UC Irvine Health Cancer Center-Newport
Costa Mesa, California, 92627, United States
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UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, 92868, United States
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University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233, United States
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University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536, United States
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Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
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Wake Forest University at Clemmons
Clemmons, North Carolina, 27012, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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