METASTATIC BREAST CARCINOMA

This early-phase trial tests two drugs—ZEN003694 and abemaciclib—together in people with advanced NUT carcinoma, breast cancer, or other solid tumors that have spread or can't be removed. The main goals are to find the safest dose and see if the combination can shrink or stabiliz…

This study tests if a precise type of proton radiation (pCSI) can help people with breast or lung cancer that has spread to the fluid-filled space around the brain and spinal cord live longer than standard x-ray radiation. About 115 participants will be randomly assigned to one o…

This study tests a type of radiation therapy called craniospinal irradiation for people whose breast or lung cancer has spread to the fluid and lining around the brain and spinal cord. The goal is to see if this treatment can help control the cancer in these areas. About 35 adult…

This study tests a new treatment for people with advanced cancers of the digestive tract, breast, ovary, or other organs. Doctors take immune cells from a patient's tumor, grow them in a lab, and give them back along with a drug called pembrolizumab. The goal is to see if this co…

This early-phase trial tests the safety and best dose of two drugs given together for people with advanced breast cancer or other solid tumors that have a protein called HER2. The drugs are pidnarulex (which stops cancer cells from repairing themselves) and trastuzumab deruxtecan…

This study tests the drug talazoparib in adults with advanced solid tumors (like breast, prostate, ovarian, pancreatic, or stomach cancer) that have certain gene changes affecting DNA repair. The drug blocks a protein called PARP, which cancer cells need to fix their DNA, potenti…

This study compares two drugs, leuprolide and goserelin, to see how well they lower estrogen in premenopausal women with breast cancer. Both drugs stop the ovaries from making estrogen, which can fuel cancer growth. The trial will test if leuprolide works as well as goserelin. Ab…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) to a single spot where breast cancer has worsened can help keep the disease from spreading further. About 46 adults with metastatic breast cancer (ER+ or HER2+) will continue their usual drug therapy …

This study tests a type of radiation therapy that targets the entire brain and spinal cord but avoids the memory center (hippocampus). It is for people with breast or lung cancer that has spread to the fluid and tissues around the brain and spinal cord. The goal is to see if this…

This early-phase study tests a wearable device that creates low-intensity electric fields (tumor treating fields) combined with either cabozantinib or a chemo-immunotherapy pair (nab-paclitaxel and atezolizumab) in people with advanced solid tumors in the abdomen or chest. The go…

This study tests whether a precise type of radiation (SBRT) can allow people with estrogen receptor-positive (ER+) breast cancer that has spread and is starting to grow again to keep using their current medication instead of switching to a new one. About 18 participants will rece…

This study tests whether combining an immunotherapy drug (cemiplimab) with a targeted radiation treatment (Y90 radioembolization) can help control breast cancer that has spread to the liver. About 11 adults with stage IV breast cancer and liver tumors will receive both treatments…

This study tests how well older adults (70+) with a certain type of advanced breast cancer tolerate a drug called abemaciclib combined with hormone therapy. Participants have already tried a similar drug that stopped working. The main goal is to track side effects and see if this…

This study tests whether adding another drug (cediranib or AZD6738) to the PARP inhibitor olaparib can shrink tumors or slow cancer growth in people with advanced BRCA-mutated breast cancer that has stopped responding to PARP inhibitors. About 60 adults with HER2-negative, BRCA-p…

This study compares two types of PET scans to see which is better at finding and tracking metastatic lobular breast cancer. About 30 adults with this cancer will receive both an experimental FES PET/CT scan and a standard FDG PET/CT scan. The goal is to improve detection and moni…

This study tests a special PET/MRI scan that uses a radioactive tracer to find HER2-positive breast cancer that has spread to the brain. Researchers want to see if the scan can show which brain tumors will respond to a standard chemotherapy drug. About 10 women with metastatic br…

This study tests whether giving radiation in three smaller doses (fractionated SRS) is better than a single large dose (standard SRS) for treating cancer that has spread to the brain. About 269 adults with certain cancers (like lung, breast, or melanoma) will be enrolled. The goa…

This study follows 700 adults with advanced or metastatic breast cancer who are taking CDK4/6 inhibitors. Researchers collect blood, tissue, and fluid samples to learn how the cancer responds and why it sometimes becomes resistant. The goal is to better predict treatment success …

This study is testing a special radioactive tracer called [18F]FTT that attaches to a protein (PARP1) found in some breast cancer cells. By using a PET scan, doctors hope to see if the tracer can show how well standard treatments (PARP inhibitors with or without immunotherapy) ar…

This study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to understand how these vessels work, which could help decide if a patient's tumor is likely to respond to certain trea…

This study collects tumor samples and medical information from 2000 adults with breast cancer that has spread or come back. The goal is to create a resource that helps researchers learn how the disease changes and responds to treatments. Participants provide samples and data but …

This study talks to 50 people with advanced breast cancer to learn what has helped them, what has been hard, and what kind of support they still need. It does not test any new drug or treatment. The goal is to design better supportive care programs for the future.

This study tests whether a portable device that creates electric fields is safe and practical for treating cancer that has spread to the lining of the spine. It includes up to 5 adults with breast or lung cancer that has spread to the spinal fluid and spine. The goal is to see if…