New radiation approach targets cancer in the brain and spine

NCT ID NCT06910761

Recruiting now Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase II trial tests whether a precise type of radiation called photon VMAT craniospinal irradiation can help people with breast or lung cancer that has spread to the fluid and lining around the brain and spinal cord. About 35 adults with this condition will receive radiation to the entire brain and spine. Researchers will measure how long the cancer stays under control in the central nervous system and how patients' quality of life changes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: photon volumetric modulated arc radiotherapy (VMAT) craniospinal irradiation
What this could lead to: If successful, this could provide an effective radiation-based treatment option for cancer that has spread to the fluid and lining around the brain and spinal cord.
What could go wrong: This is a small, early-phase trial with only 35 participants, so results may not apply to everyone. Radiation to the brain and spine can cause side effects like fatigue, nausea, and neurological symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ANATOMIC STAGE IV BREAST CANCER AJCC V8 are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm lung cancer lung neoplasm Meningeal Carcinomatosis neoplastic meningitis non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANATOMIC STAGE IV BREAST CANCER AJCC V8 METASTATIC BREAST CARCINOMA METASTATIC LUNG NON-SMALL CELL CARCINOMA METASTATIC MALIGNANT NEOPLASM IN THE LEPTOMENINGES STAGE IV LUNG CANCER AJCC V8

Contacts and locations

Locations

City of Hope Medical Center
RECRUITING

Duarte, California, 91010, United States
City of Hope at Irvine Lennar
RECRUITING

Irvine, California, 92618, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.