METASTATIC LUNG NON-SMALL CELL CARCINOMA

This early-phase study is testing a personalized vaccine made from each patient's unique tumor mutations. The goal is to see if it is safe and can help the immune system fight advanced breast cancer, melanoma, and non-small cell lung cancer. About 25 adults whose cancers have spr…

This early-phase study tests a combination of two drugs, osimertinib and tegavivint, as the first treatment for people with a certain type of advanced lung cancer that has spread. The goal is to find the safest dose and see if the combination helps shrink tumors. About 24 adults …

This study tests a radiation method that treats the entire brain and spinal cord but avoids the hippocampus, a memory center. It is for adults with breast or lung cancer that has spread to the fluid and tissues around the brain and spine. The goal is to see if this approach can d…

This study tests whether adding an experimental drug (SX-682) to a standard immunotherapy (pembrolizumab) helps shrink or control advanced non-small cell lung cancer. About 30 adults with stage IIIC or IV lung cancer that hasn't been treated yet will receive both drugs. The goal …

This early-stage trial tests the safety and best dose of combining two drugs—vismodegib and atezolizumab—in adults with advanced non-small cell lung cancer that has returned or spread. Vismodegib blocks certain enzymes that help cancer grow, while atezolizumab helps the immune sy…

This study tests if a precise type of proton radiation (pCSI) can help people with breast or lung cancer that has spread to the fluid-filled space around the brain and spinal cord live longer than standard x-ray radiation. About 115 participants will be randomly assigned to one o…

This early-phase study tests a combination of two ways to give the immunotherapy drug nivolumab: through a vein and directly into the fluid around the spine. It is for people with melanoma or lung cancer that has spread to the lining of the brain or spinal cord (leptomeningeal di…

This study tests a type of radiation therapy called craniospinal irradiation for people whose breast or lung cancer has spread to the fluid and lining around the brain and spinal cord. The goal is to see if this treatment can help control the cancer in these areas. About 35 adult…

This study tests whether adding diclofenac, a common anti-inflammatory painkiller, can help control tumor growth in people with advanced non-small cell lung cancer whose disease is starting to worsen while on immunotherapy alone. About 20 adults with stage III or IV lung cancer w…

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors. The goal is to see if this combination is safe and helps the immune system fight cancer more effectively. A…

This study tests a new drug (MRX-2843) combined with a standard treatment (osimertinib) in people with advanced EGFR-mutant non-small cell lung cancer. The goal is to find the safest dose and see how well the combination works. About 69 participants will take part in this early-p…

This early-phase trial tests a new drug (PBF-1129) combined with an existing immunotherapy (nivolumab) in 30 adults with advanced non-small cell lung cancer that has returned or spread. The main goal is to find the safest dose and understand side effects. Researchers also want to…

This study tests a combination of two drugs, sotorasib and trastuzumab deruxtecan, in people with advanced non-small cell lung cancer that has a specific KRAS G12C mutation. The goal is to see if the combination is safe and can shrink tumors. About 37 adults who have already trie…

This early-stage trial tests whether combining two drugs, carfilzomib and sotorasib, is safe and effective for people with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. About 15 adults who have already tried a KRAS-targeting drug will re…

This early-phase study tests an oral drug called S241656 in adults with advanced cancers that have certain gene changes (KRAS, BRAF, and others). The drug is given alone or with other cancer treatments. The goal is to find safe doses and see if the drug shrinks tumors. About 554 …

This study tests a new drug combination (GT103 plus pembrolizumab) in people with advanced or spreading non-small cell lung cancer that has a specific gene change called STK11. The goal is to see if the combo can shrink tumors or slow the cancer better than current options. About…

This study looks at whether getting immunotherapy in the morning or afternoon changes how well it fights advanced or metastatic solid tumors. Researchers believe the body's internal clock (circadian rhythm) might affect immune response. About 160 adults with certain cancers like …

This study tests a method called adaptive radiation planning for people with stage II to IV non-small cell lung cancer. Normally, radiation plans stay the same throughout treatment, but tumors can shrink, causing radiation to hit healthy tissue. By updating the plan at set times,…

This study tests whether giving radiation in three smaller doses (fractionated SRS) is better than a single large dose (standard SRS) for treating cancer that has spread to the brain. About 269 adults with certain cancers (like lung, breast, or melanoma) will be enrolled. The goa…

This study looks at how PET/CT scans change during chemoimmunotherapy and radiation in people with stage IV non-small cell lung cancer. Researchers want to see if these scan changes can help predict how well the cancer responds to treatment. About 80 adults who haven't had prior …

This study collects tissue samples from people with various advanced or early-stage cancers to train a new diagnostic platform called Elephas. The goal is to see how accurately it can predict whether a patient will respond to immunotherapy or chemoimmunotherapy. About 324 partici…

This study looks at how often people with metastatic non-small cell lung cancer have trouble sleeping. Researchers will ask 60 participants to fill out a sleep questionnaire to measure insomnia severity. The goal is to better understand sleep problems in this group, not to test a…