METASTATIC LUNG NON-SMALL CELL CARCINOMA
Clinical trials for METASTATIC LUNG NON-SMALL CELL CARCINOMA explained in plain language.
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New Two-Drug attack on tough lung cancer
Disease control OngoingThis early-stage study is testing a new combination of two drugs, sapanisertib and osimertinib, for people with advanced non-small cell lung cancer. The cancer must have a specific genetic change (EGFR mutation) and has gotten worse after treatment with a standard targeted drug. …
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 01, 2026 18:26 UTC
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Scientists test vitamin a boost to help immune system fight advanced lung cancer
Disease control OngoingThis early-stage study is testing a new combination treatment for advanced non-small cell lung cancer that has spread or returned. Researchers are combining a drug made from vitamin A (ATRA) with an immunotherapy drug (atezolizumab) to see if it is safe and to find the best dose.…
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1 • Sponsor: Dwight Owen • Aim: Disease control
Last updated Apr 01, 2026 14:43 UTC
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New drug cocktail aims to outsmart resistant lung cancer
Disease control OngoingThis study is testing a combination of three drugs for people with advanced lung cancer that has a specific genetic change (EGFR mutation) and has stopped responding to the usual treatment. The goal is to see if adding two antibody drugs (trastuzumab and necitumumab) to the stand…
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Double-Dose hope for devastating brain cancer spread
Disease control OngoingThis early-stage trial is testing a new way to give an immunotherapy drug called nivolumab to patients with melanoma or lung cancer that has spread to the membranes surrounding the brain and spinal cord. The goal is to see if giving the drug directly into the spinal fluid, along …
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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New drug duo tested for Tough-to-Treat lung cancer
Disease control OngoingThis early-stage trial is testing the safety and best dose of a two-drug combination for people with a specific type of advanced lung cancer. The study is for adults whose EGFR-mutant non-small cell lung cancer has continued to grow despite prior targeted therapy. Researchers wan…
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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New pill targets Tough-to-Treat cancers in brain and lungs
Disease control OngoingThis study is testing an oral medication called BDTX-1535 for adults with advanced non-small cell lung cancer or glioblastoma (a type of brain tumor) that have specific genetic changes. The goal is to find the safest and most effective dose and see if the drug can shrink tumors, …
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Black Diamond Therapeutics, Inc. • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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Double attack on lung cancer: radiation and immune drug tested
Disease control OngoingThis study is testing whether combining a targeted form of radiation therapy with an immunotherapy drug (pembrolizumab) is safe and more effective than the drug alone for patients with advanced non-small cell lung cancer that has spread. The goal is to see if the radiation helps …
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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New hope for Tough-to-Treat lung cancer: testing a powerful drug duo
Disease control OngoingThis study is testing whether combining two drugs, atezolizumab and cobimetinib, can help control advanced non-small cell lung cancer that has spread or returned and has stopped responding to a common type of immunotherapy. The trial aims to see if this combination can shrink tum…
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:30 UTC
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New brain cancer fight: can a second drug boost lung cancer treatment?
Disease control OngoingThis study is testing if adding a drug called bevacizumab to a standard lung cancer drug (osimertinib) works better to control cancer that has spread to the brain. It is for adults with a specific type of advanced lung cancer (EGFR-positive non-small cell lung cancer) who have no…
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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Scientists test new drug duo to fight tough cancers
Disease control OngoingThis early-stage study is testing a new combination of two drugs, sonidegib and pembrolizumab, for people with advanced solid tumors that have spread. The main goals are to find the safest dose of the combination and see if it helps shrink or control the cancer. The study is enro…
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 27, 2026 12:41 UTC
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New combo therapy trial offers hope for HIV patients with advanced cancers
Disease control OngoingThis is a small, early-stage safety study testing a combination of two cancer drugs, nivolumab and cabozantinib, in people living with HIV who have advanced solid tumors. The main goal is to see if the two-drug combination is safe and tolerable for this specific patient group. Re…
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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Double-Duty treatment: can radiation boost cancer immunotherapy?
Disease control OngoingThis study is testing whether adding radiation therapy to two immunotherapy drugs helps control advanced lung and colorectal cancer better than the drugs alone. It enrolled 110 patients whose cancer had spread and had stopped responding to prior treatments. The main goals are to …
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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New pill aims to target and shrink tough brain cancers
Disease control OngoingThis is a first-in-human study to find a safe dose of an experimental pill called WSD0922-FU for people with aggressive brain tumors or lung cancer that has spread to the brain. The pill is designed to block a specific protein (EGFR) that drives these cancers and may be able to r…
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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Cancer vaccine teams up with immune drugs in fight against advanced tumors
Disease control OngoingThis trial is testing whether combining an experimental cancer vaccine (CIMAvax) with approved immunotherapy drugs (nivolumab or pembrolizumab) is safe and more effective for treating advanced non-small cell lung cancer or squamous head and neck cancer. The study aims to find the…
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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New drug duo enters first human trial for Tough-to-Treat lung cancer
Disease control OngoingThis is an early-stage trial testing a combination of two oral drugs, sapanisertib and telaglenastat, for patients with advanced non-small cell lung cancer that has spread and progressed after standard treatments. The main goals are to find the safest dose of the drug combination…
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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Scientists test supercharged cord blood cells as new weapon against tough lung cancers
Disease control OngoingThis early-stage study is testing a new type of cell therapy for people with advanced non-small cell lung cancer that has spread and no longer responds to standard immunotherapy. Researchers are giving patients specially modified immune cells (called NK cells) taken from umbilica…
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1 • Sponsor: University of California, Irvine • Aim: Disease control
Last updated Mar 27, 2026 12:38 UTC
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New drug duo aims to outsmart resistant lung cancer
Disease control OngoingThis early-stage trial is testing a combination of two oral drugs, osimertinib and telaglenastat, for adults with advanced non-small cell lung cancer that has a specific genetic change (EGFR mutation) and has stopped responding to standard targeted therapy. The main goals are to …
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 27, 2026 12:38 UTC
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Early trial aims to boost brain cancer fight
Disease control OngoingThis early-stage study is testing the safety and best dose of an experimental drug called berzosertib when given alongside standard whole-brain radiation therapy. It involves patients with lung cancer that has spread to the brain. The hope is that combining the drug with radiatio…
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 27, 2026 12:38 UTC
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Scientists test new drug duo to starve and stop advanced cancers
Disease control OngoingThis study is testing whether taking two oral drugs, cediranib and olaparib, together can help control advanced cancers that have spread or cannot be surgically removed. It is for adults with specific types of advanced lung, breast, or pancreatic cancer who have already tried at …
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 27, 2026 12:37 UTC
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New combo attack on tough lung cancers
Disease control OngoingThis study is testing a combination of two drugs, trametinib and pembrolizumab, for people with advanced non-small cell lung cancer that has come back or spread after previous treatments. The goal is to see if the drugs work better together to control the cancer and to find the s…
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 23, 2026 15:18 UTC
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New cancer combo aims to supercharge immune system while taming side effects
Disease control OngoingThis study is testing a combination of three immunotherapy drugs—tocilizumab, ipilimumab, and nivolumab—in patients with advanced melanoma, non-small cell lung cancer, or bladder cancer. The main goal is to see if adding tocilizumab can help manage the serious side effects someti…
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 16, 2026 15:26 UTC
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New drug duo tested for Tough-to-Treat lung cancer
Disease control OngoingThis early-phase study is testing a combination of two drugs, brigatinib and bevacizumab, for patients with a specific type of advanced lung cancer (ALK-positive) that has worsened despite prior targeted therapy. The main goals are to find the safest dose and understand the side …
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Mar 13, 2026 15:06 UTC
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Scientists test Four-Drug cocktail in fight against tough lung cancer
Disease control OngoingThis early-stage study is testing a combination of four drugs for people with a specific type of advanced lung cancer (ALK-positive). The main goals are to find the safest dose of the new drug, ensartinib, when given with three other cancer drugs, and to see what side effects occ…
Matched conditions: METASTATIC LUNG NON-SMALL CELL CARCINOMA
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 10, 2026 12:52 UTC