Cancer vaccine plus immunotherapy shows promise in Hard-to-Treat cancers
NCT ID NCT02955290
First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 4 times
Summary
This study combines the CIMAvax EGF vaccine with immunotherapy drugs (nivolumab or pembrolizumab) to treat advanced non-small cell lung cancer and squamous head and neck cancer. The vaccine aims to slow tumor growth, while the immunotherapy helps the immune system attack cancer cells. Researchers are testing safety and effectiveness in 51 patients whose cancers have spread.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CIMAvax EGF vaccine combined with nivolumab or pembrolizumab
- What this could lead to
- If successful, this combination could offer a new treatment option that helps control advanced lung and head and neck cancers, potentially extending survival.
- What could go wrong
- This is an early-phase trial with only 51 participants, so results may not apply broadly. Side effects from the vaccine and immunotherapy can be serious, and the combination may not work better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Good Samaritan Hospital
West Islip, New York, 11795, United States
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Indiana University Melvin and Bren Simon Comprehensive Cancer Center
Indianapolis, Indiana, 46202, United States
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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St. Francis Hospital
Roslyn, New York, 11576, United States
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University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can immunotherapy boost surgery outcomes in recurrent head and neck cancer?
- Facing the fear: a new program aims to ease anxiety in advanced cancer
- Can a Chemo-Immunotherapy duo outsmart tough lung cancer?
- Can a Three-Pronged attack shrink Hard-to-Treat head and neck cancers?
- Sharper radiation boost aims to tackle head and neck cancers that return
- Could a simple assessment help older lung cancer patients tolerate chemo better?