Roswell Park Cancer Institute

This study tests whether giving a combination of chemotherapy drugs (NALIRIFOX) before surgery can help shrink pancreatic tumors that are close to major blood vessels but still removable. About 20 adults with this type of pancreatic cancer will receive the treatment to see if it …

This study tests whether adding propranolol (a beta-blocker used for heart conditions) to standard chemotherapy and immunotherapy can help people with advanced esophageal or stomach cancer that cannot be surgically removed. The drug may reduce stress hormones that can weaken the …

This study tests a new drug called pegcetacoplan added to standard chemotherapy for people with metastatic pancreatic cancer. The goal is to see if the combination is safe and helps control the cancer longer. It also looks at whether pegcetacoplan can prevent dangerous blood clot…

This study looks at whether testosterone replacement therapy (TRT) is safe and beneficial for men with low-risk prostate cancer who are on active surveillance (watchful waiting). Many men with low testosterone avoid TRT due to fears it might worsen their cancer, but this trial ai…

This study tests a program called CareMeds that teaches parents behavioral skills to help their young children (ages 3-9) with acute lymphoblastic leukemia take oral chemotherapy at home. Researchers will enroll 100 families in Buffalo, NY, and Atlanta, GA to see if the program i…

This study tests whether adding the blood pressure drug propranolol to standard chemoradiation is safe and effective for people with esophageal adenocarcinoma. About 106 participants will receive the combination, and researchers will monitor side effects and how long the cancer s…

This study tests whether adding tamoxifen (a hormone therapy) to a type of chemotherapy (liposomal doxorubicin) can shrink tumors in people with advanced triple-negative breast cancer that has spread or cannot be removed by surgery. The trial includes 30 adults whose cancer has a…

This study tests whether adding a cancer vaccine (SurVaxM) to standard chemotherapy (temozolomide) helps people with advanced neuroendocrine tumors that are growing. The vaccine trains the immune system to attack cancer cells. About 60 adults with tumors that have spread will tak…

This early-stage study tests a new combination of two drugs (trifluridine/tipiracil and talazoparib) in people with advanced colorectal or gastroesophageal cancers that have spread. The main goals are to find the safest dose and understand side effects. About 45 participants will…

This study tests a combination of a dendritic cell vaccine (which trains the immune system to attack cancer) and pembrolizumab (an immunotherapy drug) in people with breast cancer that has spread to the brain. The goal is to see if this treatment can shrink brain tumors. The stud…

This study tests whether adding an experimental drug (APL-2) to standard immunotherapy (pembrolizumab) and/or a targeted therapy (bevacizumab) can better control fluid buildup and tumor growth in people whose ovarian, fallopian tube, or peritoneal cancer has returned. About 60 ad…

This study tests a two-step treatment for people with advanced cancer that blocks their main breathing passages. First, they get low-dose radiation to shrink the tumor. Then, they receive a light-sensitive drug and a laser treatment to destroy remaining tumor tissue. The goal is …

This study tests a healthy eating program that encourages people with early-stage bladder cancer to eat more cruciferous vegetables like broccoli, kale, and cabbage. These veggies contain natural compounds that may help fight cancer cells and are delivered directly to the bladder…

This study tests a two-step approach for people with advanced or returning colorectal cancer. First, a special drug makes cancer cells glow during surgery, helping surgeons remove more of them. Then, a laser activates the drug to kill any remaining cancer cells. The goal is to im…

This study tests whether adding lamivudine, an antiviral drug, to standard chemotherapy and immunotherapy can stop small cell lung cancer from becoming resistant to treatment. About 28 adults with extensive-stage small cell lung cancer will receive the combination. The goal is to…

This early-phase trial tests whether adding a new drug called SX-682 to standard myeloma medications is safe and tolerable for people whose cancer has come back or hasn't responded to prior therapy. SX-682 works by blocking signals that suppress the immune system, potentially hel…

This study looks at people with lung, colorectal, or prostate cancer that has spread to up to 10 spots in the body. It compares starting treatment right away versus waiting 6 months to see which approach helps people live longer and maintain quality of life. About 800 participant…

This study tests whether adding an experimental drug (CDX-1140) to two standard immunotherapies (pembrolizumab and bevacizumab) can shrink tumors in people whose ovarian cancer has returned. About 80 adults with specific types of recurrent ovarian, fallopian tube, or peritoneal c…

This study looks at whether personalized nutrition and exercise plans can help reduce frailty and improve body composition in prostate cancer survivors who are on hormone therapy (androgen deprivation therapy). About 50 participants will receive tailored advice and be monitored f…

This early-stage study tests a treatment called bipolar androgen therapy for men with advanced prostate cancer that no longer responds to standard hormone therapy and has spread. The approach rapidly switches testosterone levels from very low to very high to shock cancer cells an…

This study tests two drugs together for people with Richter transformation, a fast-growing lymphoma that can arise from chronic lymphocytic leukemia. The drugs aim to block cancer growth and help the immune system attack the cancer. About 32 adults who have not responded to or ca…

This study tests a procedure called pulmonary suffusion, which delivers chemotherapy directly to the lungs through a minimally invasive method. It is for people with sarcoma or colorectal cancer that has spread to the lungs and can be surgically removed. The goal is to control an…

This study tests a low-intensity vibration board in 75 adults with blood cancers who are planning a stem cell transplant or cell therapy. The vibrations may help maintain bone density and boost immune cell activity. Researchers will measure how often patients use the board and wh…

This study tests a new drug combination (GT103 plus pembrolizumab) in people with advanced or spreading non-small cell lung cancer that has a specific gene change called STK11. The goal is to see if the combo can shrink tumors or slow the cancer better than current options. About…

This early-phase trial tests a new treatment using specially engineered immune cells (CD83 CAR T cells) for adults with acute myeloid leukemia (AML) that has returned or not responded to standard therapy. The cells are designed to find and destroy leukemia cells while reducing th…

This study is testing a three-drug combination (MeziKD) for adults with multiple myeloma that has come back or stopped responding to other treatments and has spread to form tumors in soft tissues or organs. The goal is to see if this combination can shrink these tumors and contro…

This study tests a new imaging method called photoacoustic tomography that uses light and sound to get more detailed pictures of breast tissue. It aims to help find breast cancer in women with dense breasts, where standard mammograms may miss tumors. About 400 women with suspicio…

This study tests whether doing special breathing exercises for several weeks before lung cancer surgery can lower the risk of problems like pneumonia and breathing trouble after the operation. About 220 adults with stage I to IIIB lung cancer will either do the exercises or recei…

This study tests whether a personalized activity program using a Fitbit can help people with ovarian or endometrial cancer exercise more and improve their quality of life. About 120 participants will either get the program or standard advice. The goal is to see if the program hel…

This study looks at whether non-drug approaches like physical activity, intermittent fasting, or adding a common beta-blocker (propranolol) can improve immune function and quality of life in people with multiple myeloma or related blood disorders. Researchers will measure changes…

This study tests whether a home-based breathing exercise program can reduce shortness of breath, fatigue, and improve quality of life for people who have had surgery for early-stage lung cancer. About 100 survivors will be asked to do breathing exercises regularly for several wee…

This study tests a home-based exercise program for underserved cancer survivors and their caregivers. Participants will receive tailored workouts through the YMCA to help improve physical function and quality of life. The goal is to see if this approach is practical and acceptabl…

This study tests whether adding olanzapine to standard nausea care can better manage appetite loss in head and neck cancer patients undergoing chemoradiation. About 66 adults with this cancer will receive either olanzapine plus standard care or standard care alone. The main goal …

This study tests a program called MedSupport that helps families of children with acute lymphoblastic leukemia give their daily chemo medicine at home. Missing even a few doses can raise the risk of the cancer coming back. The program works with hospitals, doctors, and parents to…

This study tests a program called Financial Compass that helps head and neck cancer patients deal with money problems caused by their illness. About 50 patients will either get the program or usual care. The goal is to see if the program is practical and helpful, since financial …

This study tests if a small device that sends a mild electrical current through the earlobes (called CES) combined with life coaching can reduce burnout and moral distress in healthcare workers who treat cancer. About 40 workers will use the device and get coaching over 12 weeks.…

This study tests whether a single, highly targeted dose of radiation (SBRT) can relieve pain and improve quality of life as well as or better than standard radiation therapy in people whose cancer has spread. About 1,500 participants with metastatic tumors causing symptoms will b…

This study tests if doing breathing exercises at home can help reduce heart and lung side effects in people getting chemotherapy for breast cancer. The exercises are designed to strengthen breathing muscles and may be easier than regular aerobic exercise for patients undergoing t…

This study is testing whether using virtual reality (VR) can help patients feel better during their bone marrow transplant hospital stay. Researchers will compare VR sessions focused on relaxation and nature to standard care alone. They want to see if VR reduces symptoms like pai…

This study looks at whether an education and navigation support tool can help patients with advanced bladder cancer and their caregivers take a more active role in treatment decisions. The program is designed for older adults who often have other health issues and limited access …

This study is testing a new, non-invasive imaging device called LC-OCT to see if it can clearly show the edges of basal cell skin cancers before Mohs surgery. About 60 adults who are already scheduled for Mohs surgery will have their cancer site scanned with this camera. The goal…

This study looks at whether giving early-stage lung cancer patients information about quality of life outcomes helps them feel more satisfied with their choice between surgery and radiation therapy. About 150 adults with stage I or II lung cancer who are eligible for both treatme…

This study follows 700 adults with advanced or metastatic breast cancer who are taking CDK4/6 inhibitors. Researchers collect blood, tissue, and fluid samples to learn how the cancer responds and why it sometimes becomes resistant. The goal is to better predict treatment success …

This study aims to see if a 3-month daily survey method is practical for understanding chronic pain and opioid use in adolescent and young adult sarcoma survivors. About 40 participants aged 12-24 at diagnosis, now in survivorship care with meaningful pain, will complete brief da…

This study tests a community workshop called I CAN that teaches people how to take action to reduce cancer in Western New York. About 200 healthy adults will attend the workshop and share their feedback. The goal is to see if this approach is practical and acceptable for building…

This study collects blood and tumor tissue from 100 people with pancreatic cancer who are about to receive standard chemotherapy. Researchers will use an artificial intelligence tool to look for biomarkers that could predict which treatment—FOLFIRINOX or Gemcitabine+Nab-paclitaxe…

This study tests a support program for breast cancer survivors in Western New York. It combines group sessions and one-on-one mentoring with a long-term survivor to help women adjust to life after treatment. The goal is to see if this program helps connect survivors to resources …

This study looks at how different risk messages about smokeless tobacco products change what people feel when using them and whether they plan to use them again. About 50 adult smokers from Western New York who are open to trying smokeless tobacco will take part. Researchers will…

This study looks at how much nicotine, cannabis, and harmful chemicals end up in the blood and urine of young adults (ages 18-25) who use e-cigarettes, cannabis, or both. Researchers will compare toxin levels and use behaviors among different user groups. The goal is to better un…

This study tests a patient navigation program for women newly diagnosed with breast cancer. The program helps patients understand their care options, connect with support services, and overcome barriers like transportation or financial concerns. Researchers will measure how many …

This study looks at whether a supervised exercise and nutrition program in the community is practical and helpful for cancer survivors. Researchers want to see if it improves survivors' confidence, physical fitness, and quality of life. The study will include 150 adults who have …

This study looks at whether daily menthol smokers can still taste or smell menthol in cigarettes that claim to have removed it. Researchers will compare cigarettes sold in New York (where menthol is still allowed) and California (where menthol was banned in 2022). The goal is to …

This study looks at how daily smokers respond to advertisements that claim certain smokeless tobacco products are less harmful than cigarettes. About 160 adult smokers from Western New York will watch ads and share their opinions, including whether they'd consider buying the prod…

This study interviews 40 adults aged 18-30 who use both tobacco and cannabis at least weekly. Researchers want to understand how people start, increase, and keep using these substances together. The goal is to gather personal stories and insights, not to test a treatment.