Roswell Park Cancer Institute

This early-stage trial is testing a new treatment called GB-5267 for people with ovarian cancer that no longer responds to platinum-based chemotherapy. GB-5267 is a type of immune cell therapy (CAR T cell) that has been engineered to better target cancer cells and includes an ext…

This phase II trial tests whether adding an experimental antibody called GT103 to the immunotherapy drug pembrolizumab can help people with advanced STK11-mutant non-small cell lung cancer. The study enrolls 28 adults whose cancer has worsened despite prior pembrolizumab treatmen…

This early-phase trial is testing a new cell therapy called CD83 CAR T cells in 26 adults with acute myeloid leukemia (AML) that has returned or not responded to treatment. The therapy uses a patient's own immune cells, genetically modified to recognize and attack a protein (CD83…

This early-stage study tests a treatment called bipolar androgen therapy for men with advanced prostate cancer that no longer responds to standard hormone therapy. The treatment involves raising and lowering testosterone levels in a controlled way to try to slow cancer growth. Th…

This early-phase trial tests whether adding pegcetacoplan to standard chemotherapy (mFOLFIRINOX) is safe and effective for people with metastatic pancreatic cancer. Pegcetacoplan targets part of the immune system to possibly slow tumor growth and reduce blood clots, a common comp…

This study tests a two-step approach during surgery for people with advanced or returning colorectal cancer. First, a drug makes cancer cells glow under blue light so surgeons can see and remove them. Then, red laser light activates the drug to kill any remaining cancer cells. Th…

This phase 2 trial tests whether adding an experimental immune-boosting drug (CDX-1140) to two standard immunotherapies (pembrolizumab and bevacizumab) can shrink tumors in people whose ovarian cancer has returned. About 80 adults with recurrent ovarian, fallopian tube, or perito…

This study tests whether adding a vaccine called SurVaxM to the chemotherapy drug temozolomide can help control advanced neuroendocrine tumors that are growing. About 60 adults with these rare cancers will receive either the combination or chemo alone. The goal is to see if the v…

This phase II trial tests whether combining nemtabrutinib (a targeted drug) with pembrolizumab (an immunotherapy) can shrink tumors in 32 people with Richter transformation, an aggressive lymphoma that arises from chronic lymphocytic leukemia. Participants must have failed or be …

This study tests whether testosterone replacement therapy (TRT) is safe and beneficial for men with low testosterone and early-stage prostate cancer who are on active surveillance. Researchers will track cancer progression, quality of life, and whether men stay on active surveill…

This phase IIa trial tests a combination of a dendritic cell vaccine (targeting HER2/HER3 proteins) and the immunotherapy drug pembrolizumab (Keytruda) in 23 women with breast cancer that has spread to the brain. The vaccine aims to train the immune system to attack cancer cells,…

This study tests a healthy eating program that encourages people with early-stage bladder cancer to eat more cruciferous vegetables like broccoli, kale, and cabbage. These veggies contain natural compounds that may help fight cancer cells. Researchers want to see if this diet cha…

This early-phase study tests a combination of two drugs—trifluridine/tipiracil (a chemotherapy) and talazoparib (a targeted therapy)—in people with advanced colorectal or gastroesophageal cancers that have spread. The main goals are to find the safest dose and understand side eff…

This study tests whether combining tamoxifen (a hormone blocker) with a targeted form of chemotherapy (liposomal doxorubicin) can shrink tumors in people with advanced triple-negative breast cancer that has spread or cannot be removed by surgery. The trial enrolls 30 adults who h…

This study tests a behavioral program called CareMeds that teaches parents skills to help their young children (ages 3-9) with acute lymphoblastic leukemia take oral chemotherapy at home. Researchers will enroll 100 families across two cities to see if the program is feasible and…

This early-phase trial tests whether adding an experimental drug called SX-682 to a standard three-drug regimen is safe for people with multiple myeloma that has relapsed or become resistant. SX-682 works by freeing up immune cells to better kill cancer cells. The study will enro…

This study tests a two-step treatment for people with advanced cancer that blocks their airways. First, they get low-dose radiation to shrink the tumor. Then, they receive a light-activated drug through an IV, followed by a laser to destroy remaining tumor cells. The goal is to i…

This phase 2 trial is testing a chemotherapy combination called NALIRIFOX given before surgery to people with borderline resectable pancreatic cancer. The goal is to shrink the tumor enough to allow successful removal and reduce the chance of the cancer coming back. The study wil…

This study tests MedSupport, a program designed to help families of children with acute lymphoblastic leukemia give their child daily oral chemotherapy at home. Missing even a few doses can raise the risk of cancer returning. The program uses a special pill bottle cap that tracks…

This study tests whether adding an experimental drug (APL-2) to standard immunotherapy (pembrolizumab) and/or a targeted therapy (bevacizumab) can better control recurrent ovarian, fallopian tube, or peritoneal cancer that causes fluid buildup in the belly or chest. About 60 adul…

This study tests a procedure called pulmonary suffusion, which delivers the chemotherapy drug cisplatin directly to the lungs through a minimally invasive method. The goal is to control any remaining cancer cells after surgery or ablation in patients with sarcoma or colorectal ca…

This phase 3 trial tests whether treating 1 to 10 metastatic tumors right away with precise radiation improves survival compared to waiting 3 months. It includes 800 adults with lung, colorectal, or prostate cancer that has spread to a few spots. Participants are randomly assigne…

This phase II trial tests a combination of three drugs—mezigdomide, carfilzomib, and dexamethasone—in 28 patients with multiple myeloma that has returned or not responded to treatment and has spread to soft tissues or organs. The goal is to see if this combo can shrink tumors or …

This study tests adding propranolol, a blood pressure medicine, to standard chemoradiation for people with esophageal adenocarcinoma. About 106 participants will receive the combination to see if it is safe and helps control the disease longer. The goal is to improve treatment wi…

This study tests whether adding lamivudine, an antiviral drug, to standard chemotherapy and immunotherapy can prevent or delay drug resistance in people with extensive-stage small cell lung cancer. About 28 adults will receive the combination treatment. The goal is to see if this…

This phase 2 trial is testing whether adding propranolol, a common beta-blocker used for heart conditions, to standard chemotherapy and pembrolizumab (an immunotherapy) can improve treatment response in people with advanced esophageal or gastroesophageal junction cancer that cann…

This study tests whether low-intensity mechanical stimulation (LIMS) vibration therapy can help blood cancer patients who are about to receive a stem cell transplant or cell therapy. The vibration board sends gentle waves through the bones, which may stimulate bone growth, improv…

This pilot study is testing a handheld imaging device called LC-OCT to see if it can clearly show the edges of basal cell skin cancers before Mohs surgery. Researchers will enroll 60 adults who are already scheduled for Mohs surgery. The goal is to find out if the images are good…

This study explores whether photoacoustic imaging—a technique that uses light and sound waves—can better detect breast cancer in women with dense breasts, where mammograms often fall short. Researchers will scan up to 400 women, including those with suspicious or confirmed breast…

This study tests whether using virtual reality (VR) can improve symptoms like pain, anxiety, and fatigue in patients receiving a bone marrow transplant. About 28 adults will be randomly assigned to either VR sessions or standard care during their hospital stay. The goal is to see…

This study tests if using a small device that sends a mild electrical pulse to the earlobes (called cranial electrotherapy stimulation) along with life coaching can reduce burnout and moral distress in healthcare workers who treat cancer patients. About 40 doctors, nurses, and ot…

This study tests whether doing breathing exercises at home can help reduce heart and lung side effects in people being treated for breast, head/neck, or lung cancer. The exercises are designed to strengthen breathing muscles and may be easier than regular aerobic exercise for pat…

This study tests whether a home-based breathing exercise program can help people who have finished treatment for early-stage lung cancer (stages I-III) breathe easier, feel less tired, and stay more active. About 100 survivors will do breathing exercises at home for several weeks…

This phase 2 trial tests whether doing special breathing exercises (respiratory muscle training) for a few weeks before lung cancer surgery can reduce serious lung complications like pneumonia and breathing trouble. About 220 people with stage I-IIIB lung cancer will either do th…

This study tests whether personalized nutrition and exercise plans can reduce frailty and improve body composition in prostate cancer survivors who are on hormone therapy (ADT). Fifty participants will receive diet advice, exercise coaching, and educational sessions. Researchers …

This study tests whether a supervised 12-week exercise and nutrition program in a community setting is practical and helpful for cancer survivors. About 150 participants, including survivors and their caregivers, will wear activity trackers, attend exercise sessions, and receive …

This study tests whether a single, precise dose of radiation (SBRT) can relieve pain and improve quality of life in people with cancer that has spread, compared to the usual multiple sessions of standard radiation. About 1,500 participants with metastatic tumors causing symptoms …

This phase 2 trial tests whether adding olanzapine to standard care helps manage appetite loss in head and neck cancer patients undergoing chemoradiation. About 66 adults will receive either olanzapine plus standard symptom management or standard care alone. The main goal is to s…

This trial tests a special education and navigation program for people with advanced bladder cancer and their caregivers. The program provides guidance, nutritional advice, and distress screening to help them better manage treatment decisions and care coordination. Researchers ho…

This study tests whether a personalized physical activity program using a wearable device (like a Fitbit) can help people with ovarian or endometrial cancer exercise more and improve their quality of life. About 120 participants will either receive tailored activity goals and fee…

This study offers a home-based exercise program for underserved cancer survivors and their caregivers. The goal is to see if this program helps improve physical function and quality of life. Participants will follow tailored exercise videos for 12 weeks. The study aims to make su…

This study looks at whether non-chemo approaches like physical activity, intermittent fasting, or adding a beta-blocker (propranolol) can improve immune function and quality of life in people with multiple myeloma or related blood disorders. Researchers will measure changes in im…

This study tests a new program called Financial Compass that helps head and neck cancer patients deal with money problems caused by their illness. About 50 patients who are struggling financially will either get the program or usual care. The goal is to see if the program is prac…

This study looks at how daily smokers in Western New York react to advertisements that describe smokeless tobacco products as having lower health risks than cigarettes. Participants will watch ads and share their opinions, including how likely they would be to buy the product. Th…

This study interviews 40 young adults aged 18-30 who use both tobacco (cigarettes or vaping) and cannabis at least weekly. Researchers want to learn how and why people start, increase, and keep using both substances together. The goal is to better understand these behaviors, not …

This study looks at how messages about the risks of smokeless tobacco products change what people feel when using them and whether they plan to use them again. About 50 adult smokers from Western New York who are open to trying smokeless tobacco will take part. Researchers will m…

This study looks at how much nicotine, cannabis, and harmful chemicals end up in the blood and urine of young adults (ages 18-25) who use e-cigarettes, cannabis, or both. Researchers will compare these levels across different user groups and also track their habits through questi…

This study collects blood and tumor samples from 100 people with pancreatic cancer who are about to receive standard chemotherapy before surgery. Researchers will use an artificial intelligence algorithm to analyze the tumor tissue and look for biomarkers that predict which treat…

This pilot study is testing whether a 3-month daily survey program (called ecological momentary assessment) is practical and acceptable for tracking chronic pain and opioid use in adolescent and young adult sarcoma survivors. About 40 survivors aged 12 to 24 at diagnosis, who sti…

This study looks at whether daily menthol smokers can tell if a cigarette has menthol flavor or not. Researchers want to see if cigarettes sold in California (where menthol is banned) still taste minty to smokers from New York. The goal is to understand how well people can detect…

This study tests a workshop called I CAN that teaches people how to work together to reduce cancer in their community. About 200 adults in Western New York will join to see if the program is practical and well-liked. The goal is to empower local action, not to treat or cure cance…

This study is testing a patient navigation program for women newly diagnosed with breast cancer. The program helps patients understand their care options, connect to support services, and manage barriers like transportation or finances. Researchers want to see if this approach im…

This study tests a post-treatment support program for breast cancer survivors in Western New York. The program includes group sessions and one-on-one mentoring with a long-term survivor to help with self-assessments and connecting to resources. The goal is to see if this program …

This study follows 700 adults with advanced or metastatic breast cancer who are taking CDK4/6 inhibitors (ciclib drugs). Researchers collect blood, tissue, and fluid samples to understand how the cancer responds, why resistance develops, and how well patients do over time. The go…

This study looks at whether giving early-stage lung cancer patients detailed information about quality of life outcomes helps them feel more satisfied with their choice between surgery and radiation therapy. About 150 patients will be enrolled, and researchers will measure decisi…