One-Shot radiation may ease cancer pain as well as multiple sessions

NCT ID NCT04068649

Recruiting now Symptom relief Sponsor: Roswell Park Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a single, precise dose of radiation (SBRT) can relieve pain and improve quality of life in people with cancer that has spread, compared to the usual multiple sessions of standard radiation. About 1,500 participants with metastatic tumors causing symptoms will be randomly assigned to one of the two approaches. The goal is to see if the faster treatment works just as well with fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy (SBRT or standard palliative radiation)
What this could lead to: If successful, this could show that a single, precise dose of radiation works as well or better than multiple standard doses for relieving pain and improving quality of life in people with metastatic cancer.
What could go wrong: This is a phase 2 trial, so results are still preliminary. The single-dose approach may not control pain as effectively for all patients, and there could be unknown side effects from the higher dose per session.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for METASTATIC MALIGNANT NEOPLASM are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

metastatic malignant neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC MALIGNANT NEOPLASM

Contacts and locations

Locations

Good Samaritan Hospital
RECRUITING

West Islip, New York, 11795, United States
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
The Cancer Institute at St. Francis Hospital
RECRUITING

East Hills, New York, 11548, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.