One-Shot radiation may ease cancer pain as well as multiple sessions
NCT ID NCT04068649
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a single, precise dose of radiation (SBRT) can relieve pain and improve quality of life in people with cancer that has spread, compared to the usual multiple sessions of standard radiation. About 1,500 participants with metastatic tumors causing symptoms will be randomly assigned to one of the two approaches. The goal is to see if the faster treatment works just as well with fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
radiation therapy (SBRT or standard palliative radiation)
What this could lead to
If successful, this could show that a single, precise dose of radiation works as well or better than multiple standard doses for relieving pain and improving quality of life in people with metastatic cancer.
What could go wrong
This is a phase 2 trial, so results are still preliminary. The single-dose approach may not control pain as effectively for all patients, and there could be unknown side effects from the higher dose per session.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Good Samaritan Hospital
RECRUITINGWest Islip, New York, 11795, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Roswell Park Cancer Institute
RECRUITINGBuffalo, New York, 14263, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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The Cancer Institute at St. Francis Hospital
RECRUITINGEast Hills, New York, 11548, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••