Roswell Park Cancer Institute

This study tests a new treatment for people with advanced non-small cell lung cancer that has not responded to standard therapies. The approach combines a light-activated drug (ASP-1929) that targets and kills tumor cells with an immunotherapy (cemiplimab) that boosts the immune …

This early-phase study tests a new treatment called GB-5267, which uses a patient's own immune cells (CAR T cells) that are 'armored' with a protein (IL-18) to better target and attack ovarian cancer cells. The study includes 18 adults with platinum-resistant ovarian cancer, mean…

This study tests whether adding a cancer vaccine (CIMAVAX-EGF) to standard targeted pills (sotorasib or adagrasib) can better control advanced lung cancer with a KRAS G12C mutation. About 29 adults with stage III or IV non-small cell lung cancer will receive the vaccine plus one …

This study looks at whether a new type of ultrasound, called transperineal micro-ultrasound, can better find prostate cancer during a biopsy. Instead of placing the probe in the rectum, it is placed on the skin between the scrotum and anus, using higher sound wave frequencies for…

This study tests if doing breathing exercises with a handheld device and cycling on a stationary bike at home can improve lung health in current and former smokers aged 50 and older. The goal is to see if these programs are practical and can help lower the risk of lung cancer. Tw…

This study tests whether a low dose of psilocybin (from magic mushrooms) combined with psychotherapy can safely help reduce chronic pain in 20 cancer patients who already take opioids. The approach aims to address not just physical pain but also emotional and spiritual distress. …

This study looks at how using nicotine vapes before or after THC changes the amount of THC that gets into the bloodstream. Sixty adults who regularly use both THC and nicotine vapes will take part. The goal is to understand the safety and effects of combining these products, whic…

This study aims to compare how quickly and strongly THC enters the bloodstream when vaped as a liquid versus smoked as cannabis. Researchers will measure THC levels in blood and track any side effects in 40 healthy adults who currently use both products. The goal is to better und…